Navigation Links
Nerviano Medical Sciences Invited by EORTC-NCI-AACR to Present the State-of-the-Art of Aurora
Date:10/23/2008

lective inhibitor of the entire Aurora kinase family (A, B and C), which, terminated Phase I studies and is now undergoing clinical Phase II trials in solid tumours and blood cancers at some of the most widely acknowledged international clinics: Erasmus Medical Center, Rotterdam, Policlinico Gemelli, Rome, Gustave Roussy, Villejuif, France, University of California, Los Angeles (UCLA) and University of California, San Francisco (UCSF) Fox Chase Cancer Center, Philadelphia, to name some of the most important. "This low molecular weight compound is inhibiting growth of tumour cells by interacting with mitosis during cell proliferation for which Aurora kinases are essential."

During the EORTC-NCI-AACR Symposium a recently identified biomarker used to assess PHA 739358 activity will also be presented by Dr. Bernard Laffranchi, NMS. The marker, Histone H3, is phosphorylated by Aurora kinases and is strongly reduced following treatment with the compound. "This phenomenon was initially highlighted in experimental tumour models and was recently confirmed by findings obtained from patient biopsies", explains Laffranchi. A decreased phosphorylation of Histone H3 in patients treated with PHA 739358 supports this hypothesis whereby the anti-cancer activity exerted by the compound is mediated through inhibition of Aurora kinases.

"Results obtained to date in humans reveal that PHA 739358 is a molecule with a good tolerability profile and promising hints of activity were seen," states Dr. Colotta. In Phase I trials, PHA 739358 was administered intravenously to patients with advanced and progressive solid tumours. In 20% of patients treated the disease stabilised, half of which for a period exceeding six months in subjects affected by cancer of the kidney, oesophagus, ovary, colon or non-small cell lung cancer (NSCLC). Toxicity, ranged from slight to moderate, was reversible and easily manageable from a clinical point of view. "In Phase I trials a partial response to
'/>"/>

SOURCE Nerviano Medical Sciences
Copyright©2008 PR Newswire.
All rights reserved

Page: 1 2 3

Related medicine technology :

1. Inverness Medical Innovations Participates in Meeting on HIV/AIDS with UN Secretary-General
2. TriReme Medical Inc. Receives CE Marking for Antares(TM) Coronary Stent System
3. News Media Advisory: Worlds Leading Surgical Oncologists to Gather at McLaren Regional Medical Center to Present Latest Work on Breast, Gastrointestinal Cancer Treatments
4. Texas Cardiac Arrhythmia Institute at St. Davids Medical Center Selected to Conduct Clinical Trial for Device to Treat Atrial Fibrillation
5. Photos: NIH Launches New Web Site for Parents on Medical Research Studies for Children
6. Resurgent Health and Medical Announces That Childrens Hospitals and Clinics of Minnesota has Ordered 25 CleanTech Automated Handwashing Systems
7. International Medical Corps Matched with Top 25 American Express Members Project, Saving the Lives of Malnourished Children
8. Concentric Medical to Sponsor Randomized Trial
9. MedNet Solutions to Sponsor and Exhibit at the 2008 Advanced Medical Technology Association Conference in Washington, D.C.
10. KGI Professor Ian Phillips Awarded Defense Grants for Medical Combat Research
11. 7 Health Ventures Invests in Tulip Medical
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/11/2014)... 2014 Research and Markets  has announced ... 2014-2018" report to their offering. ... is a hollow needle commonly used with a syringe ... extract fluids from it. A hypodermic needle is used ... that cannot be ingested. Hypodermic needles are broadly classified ...
(Date:7/11/2014)... -- On Thursday, July 10, 2014, ... Jones Industrial Average finished the day 0.42% lower at 16,915.07, ... losses were broad based as eight out of ten sectors ... Sector Index ended the day at 711.88, down 0.02%, while ... Investor-Edge has initiated coverage on the following equities: Covidien PLC ...
(Date:7/11/2014)... , July 11, 2014  Veran Medical ... announced today the positive, cost-effective final results ... SPiNPerc™ procedure. The SPiNPerc endobronchial percutaneous biopsy ... percutaneous approach to biopsy when a traditional ... and physicians experience positive financial outcomes when ...
Breaking Medicine Technology:Global Hypodermic Needles Market 2014-2018: Key Vendors are Becton, Dickinson and Co, Covidien, Retractable Technologies and Terumo Corp. 2Global Hypodermic Needles Market 2014-2018: Key Vendors are Becton, Dickinson and Co, Covidien, Retractable Technologies and Terumo Corp. 3Health Care Equipment Equities Movers and Shakers -- Research on Covidien, Baxter, DexCom, and Boston Scientific 2Health Care Equipment Equities Movers and Shakers -- Research on Covidien, Baxter, DexCom, and Boston Scientific 3Health Care Equipment Equities Movers and Shakers -- Research on Covidien, Baxter, DexCom, and Boston Scientific 4Veran Medical Publishes Lung Cancer Patient Management Study 2
... OAK BROOK, Ill. , July 12 The University ... agreement to Ascent, a leader in health care resource sustainability. The agreement, ... 1, 2010 . Under the contract, Ascent will offer single-use device (SUD) ... , , , ...
... July 12 ( http://www.myprgenie.com ) -- Medrium, Inc., one ... announced it has signed a partnership agreement with RelayHealth to use ... LabCorp and to provide LabCorp results to physicians utilizing the Medrium ... , ...
Cached Medicine Technology:University HealthSystem Consortium Awards Single-Source Agreement to Ascent for Medical Device Reprocessing Services 2University HealthSystem Consortium Awards Single-Source Agreement to Ascent for Medical Device Reprocessing Services 3Medrium Partners With RelayHealth 2Medrium Partners With RelayHealth 3
(Date:7/13/2014)... Recently, iFitDress.com, one of the most famous ... collection of brown evening dresses for worldwide ... at discounted prices, up to 50% off. , ... they are carefully made according to most fashionable styles. ... also offers pretty accessories: wedding shoes, dancing shoes, sandals, ...
(Date:7/13/2014)... variations in the quality of care are the most ... varies widely between regions within Europe, according to the ... date, published in The Lancet Oncology . , ... cancers of the blood has increased over the past ... targeted drugs in the early 2000s such as rituximab ...
(Date:7/13/2014)... research in Nature Genetics identifies a ... that causes eosinophillic esophagitis (EoE), opening up potential ... food allergy. , EoE is a chronic ... triggered by allergic hypersensitivity to certain foods and ... cells called eosinophils (part of the body,s immune ...
(Date:7/13/2014)... (PRWEB) July 13, 2014 Victorian Hotel ... by promoting the rental of bikes for its "Cycle ... downtown Victorian Hotel to tour the area using a ... tax. Bicycle enthusiasts love to call Vancouver home, as ... for cycle travel and picturesque journeys through the countryside. ...
(Date:7/13/2014)... 2014 Advanced boilers are preferred ... amount of fossil fuels, produce high-capacity power, emit ... increased global warming and climate change concerns, many ... harmful gas emissions and pollutants coming from fossilfuel-based ... the global advance boilers market., The global power ...
Breaking Medicine News(10 mins):Health News:2014 Brown Evening Dresses Added To iFitDress.com 2Health News:The Lancet Oncology: Differences in treatment likely to be behind differing survival rates for blood cancers between regions within Europe 2Health News:The Lancet Oncology: Differences in treatment likely to be behind differing survival rates for blood cancers between regions within Europe 3Health News:Study finds cause of mysterious food allergy, suggests new treatment strategy 2Health News:Study finds cause of mysterious food allergy, suggests new treatment strategy 3Health News:Victorian Hotel Creates Excitement by Adding "Cycle the City" Bike Rentals for Its Vancouver Hotel Rooms 2Health News:North America Advanced Boilers Market is Expected to Reach $518.7billion by 2019 - New Report by MicroMarket Monitor 2Health News:North America Advanced Boilers Market is Expected to Reach $518.7billion by 2019 - New Report by MicroMarket Monitor 3
... Brain Center America,s New Neuroactive Exercise Bike Trains the Body and Brain ... ... Fitness centers are entering the next lap of their evolution with the ... body and the brain as a joint fitness program , Stephane Bergeron, ...
... Holdings Inc.,(OTC Bulletin Board: CLXS), a leading developer ... that their life science research,portal http://www.BiomedExperts.com ... in December has exploded to over 60,000 per ... , (Logo: ...
... Inc., the nation,s largest independent behavioral health care ... an agreement with CareIntegra to provide enhanced integrated ... product offerings. (Logo: http://www.newscom.com/cgi-bin/prnh/20090106/PH55551LOGO ... ValueOptions(R) will collaborate to develop and conduct a ...
... TV Teacher, LLC(TM) announces the,donation of their video-modeling programs ... Bronx, and Staten Island. , ... Ellis, a mother struggling to help her frustrated five-year-old ... an unsuccessful two years of,"traditional" therapy, she realized she ...
... Pharmaceutical,Inc. (Nasdaq: BMRN ) today announced that ... company update at the 27th,Annual J.P. Morgan Healthcare Conference ... a.m. PT. , Interested parties ... call,via the investor section of the BioMarin website, ...
... Jan. 7 Atlanta-based Billian Publishing, Inc.,owners of ... , (Logo: ... Porter Research was founded in 1989 just as ... of accelerated innovation. Since then, new,and established companies ...
Cached Medicine News:Health News:Neuroactive Bike: America's First And Only Mind-Body Fitness Equipment Used For The Ultimate Brain Fitness Gym Program Launched This Month At Lady Of America Fitness Center 2Health News:Neuroactive Bike: America's First And Only Mind-Body Fitness Equipment Used For The Ultimate Brain Fitness Gym Program Launched This Month At Lady Of America Fitness Center 3Health News:Neuroactive Bike: America's First And Only Mind-Body Fitness Equipment Used For The Ultimate Brain Fitness Gym Program Launched This Month At Lady Of America Fitness Center 4Health News:Collexis BiomedExperts Hits 80,000 Registered Users Within the First Year! 2Health News:Collexis BiomedExperts Hits 80,000 Registered Users Within the First Year! 3Health News:ValueOptions(R) Enters Agreement with CareIntegra to Provide Integrated Health Services 2Health News:New York Schools Receive Program for Children with Autism 2Health News:BioMarin to Present at the 27th Annual J.P. Morgan Healthcare Conference 2Health News:Billian Publishing, Inc. Announces Acquisition of Porter Research 2
CRP Liquid Conrtols level 3...
Therapeutic Drug Calibrator Series...
The IRN method used on the Dimension clinical chemistry system is an in vitro diagnostic test intended for the quantitative determination of iron in serum....
The AST method used on the Dimension clinical chemistry system is an in vitro diagnostic test intended for the quantitative determination of aspartate aminotransferase activity in serum or plasma...
Medicine Products: