Nerviano Medical Sciences Invited by EORTC-NCI-AACR to Present the State-of-the-Art... ( NERVIANO Italy October 23 /- -...)

Nerviano Medical Sciences Invited by EORTC-NCI-AACR to Present the State-of-the-Art of Aurora

Date:10/23/2008

NERVIANO, Italy, October 23 /PRNewswire/ --

- First Responses in Solid Tumours Reported.

Aurora inhibitors play a key role in cell duplication and are implicated in both the onset and progression of numerous types of tumour. A lecture focusing on Aurora kinase inhibitors will be presented today by Dr. Bernard Laffranchi during the 20th EORTC-NCI-AACR Symposium "Molecular Targets and Cancer Therapeutics" organised from 21st to 24th October 2008 in Geneva. Dr Laffranchi, Director Clinical Research of Nerviano Medical Sciences, the largest R&D cancer drug stand alone company in Europe (http://www.nervianoms.com) has been invited to give a presentation on the state-of-the-art of Aurora kinase inhibitors, providing a comprehensive summary of ongoing clinical studies being performed on this molecular target to which increasing attention is being paid by the experts.

"Nerviano Medical Sciences (NMS) has been chosen by these prestigious scientific societies in view of the fact that the Italian centre has a recognized leadership in research & development of Aurora inhibitors," explains Francesco Colotta, Research & Development Director at NMS. Indeed, compounds capable of inhibiting activity of this kinase family and displaying anti-tumour efficacy in a wide range of solid and blood cancers models were first identified at Nerviano. Moreover, emphasises Dr. Colotta, the Aurora inhibitors discovered at Nerviano were the first to be evaluated in patients and to undergo clinical development.

"This symposium will be organised in a particularly pragmatic fashion and provides a wide-ranging overview of all data collected with regard to future treatment of patients," underlines Dr. Colotta. "Preliminary results of human clinical Phase II trials with Aurora inhibitors carried out by NMS are underway," continues Dr. Colotta. The product at the most advanced stage of development is PHA 739358, a se
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