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NephRx Corp. Awarded New U.S. Patent for Oral Mucositis Agent NX002
Date:3/23/2011

KALAMAZOO, Mich., March 23, 2011 /PRNewswire/ -- NephRx Corporation today announced issuance of a new U.S. patent for its novel peptide NX002, which currently is in preclinical development for the treatment of oral mucositis.  Previously, NephRx reported that NX002 had demonstrated significant efficacy when tested in well-validated animal models of oral mucositis.  Mucositis is a debilitating and often dose-limiting condition that affects more than 400,000 cancer patients who receive chemotherapy or radiation therapy in the U.S. each year.  Current treatment options are limited.

"Issuance of this most recent patent further confirms the promising utility of NX002 as a potential treatment for oral mucositis," said James Koziarz, President and CEO of NephRx.  "Mucositis is a painful and debilitating side effect of cancer therapy that can be dose-limiting, jeopardizing patients' chances for successful treatment.  We look forward to advancing the detailed NX002 toxicity studies needed to initiate the mucositis clinical program for NX002."

NX002 is a peptide derived from the naturally occurring growth factor AMP-18, which has been shown to stimulate the growth of epithelial cells and to promote mucosal wound healing after injury.  Its multiple biological properties include the ability to protect cells from injury, stimulate cell growth and migration, and increase the accumulation of proteins that bind cells together.  In a study in a well-validated mucositis model, animals treated with NX002 had reduced levels of oral ulceration and a more rapid recovery, with no evidence of toxicity.  NephRx has begun the preclinical toxicology studies of NX002 needed to initiate mucositis clinical trials targeted for late 2011 or early 2012.

The U.S. Patent and Trademark office issued Patent No. 7910543, "Control of growth and repair of gastro-intestinal tissues by gastrokines and inhibitors."  Rights to this patent,
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SOURCE NephRx Corporation
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