NeoVista, Inc. Presents New Data on Its Novel Wet AMD Ther... ( One-Year Data Provides Ophthalmolo...)

NeoVista, Inc. Presents New Data on Its Novel Wet AMD Therapy at AAO

Date:11/12/2007

One-Year Data Provides Ophthalmologists Critical Insight on Novel Beta

Radiation Epiretinal Therapy

NEW ORLEANS, Nov. 12 /PRNewswire/ -- NeoVista, Inc. revealed today new data from a one-year feasibility study of the company's novel beta radiation epiretinal therapy for the wet form of age-related macular degeneration (AMD) at the 2007 Annual Meeting of the American Academy of Ophthalmology in New Orleans, Louisiana.

NeoVista initiated this study to test the efficacy and safety of their novel beta radiation epiretinal therapy when used in combination with Avastin(R). In the ongoing nonrandomized, multi-center feasibility study, 34 subjects with predominantly classic, minimally classic, or occult (with no classic) CNV received a single 24 Gy treatment of NeoVista's epiretinal therapy in combination with two injections of Avastin, one dose at the time of radiation delivery and another one month later.

After twelve months follow-up, subjects experienced a mean improvement of visual acuity of 13.1 letters using the Early Treatment Diabetic Retinopathy Study (ETDRS) test. 96% of patients lost less than 15 letters of visual acuity. Only 15% of patients in the study required additional injections of Avastin throughout the year and only 12% of patients experienced adverse events related to the procedure (retinal tear, retinal detachment, subretinal hemorrhage, and vitreous hemorrhage).

Jeffrey S. Heier, MD, a retinal specialist and partner at Ophthalmic Consultants of Boston, presented the one-year data attained from 27 trial participants (mean age, 72 years) from June 2006 to April 2007 in two centers in Brazil and one in Mexico. Dr. Heier is a consultant for NeoVista, Inc.

"The one-year data provides important evidence that this novel concomitant treatment approach may provide more sustainable options for those suffering from this degenerative condition," said Dr. Heier. "NeoVista's targeted beta radiation in
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