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NeoStem Signs Definitive Merger Agreement to Acquire Amorcyte in Equity Transaction
Date:7/14/2011

NEW YORK, July 14, 2011 /PRNewswire/ -- NeoStem, Inc. (NYSE Amex: NBS) ("NeoStem" or the "Company"), an international biopharmaceutical company, announced the signing of a definitive merger agreement whereby NeoStem will acquire Amorcyte, Inc. ("Amorcyte"),  a  development stage cell therapy company focusing on novel treatments for cardiovascular disease. Amorcyte's lead product candidate, AMR-001, is ready to initiate a Phase II study for the  treatment of acute myocardial infarction (AMI).

Of the approximately 800,000 Americans who suffer an AMI each year, twenty percent or 160,000 patients remain at risk to subsequently experience progressive deterioration in heart muscle function and as a consequence, an increase in major adverse cardiac events (MACE). AMR-001 targets treatment of this unmet medical need. Based on a comprehensive pre-clinical program which identified a mechanism of action with a highly purified homogeneous cell population, a Phase I study was completed. Results of the clinical study identified a therapeutic dose (biological threshold dose) that was associated with a significant improvement in perfusion (p=0.01) in the peri-infarct zone. The Phase I clinical trial results for AMR-001 suggest that this cell based therapy improves microvascular density (perfusion) and rescues at-risk cardiomyocytes (cardiac muscle cells) from hibernation and apoptosis (cell death).  The logical implications of those results, and the subject of future studies, will explore the potential of AMR-001 to preserve heart muscle function and consequently improve both quality-of-life and longevity by reducing the incidence and severity of MACE.

AMR-001 is an autologous, bone marrow derived, pharmaceutical grade cell-based product that uses a cell population enriched for CD34+CXCR4+ cells. Studies have shown that these cells act as a natural repair mech
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SOURCE NeoStem, Inc.
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