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Nemours Center for Childhood Cancer Research Team at the Alfred I. duPont Hospital for Children Identifies the Function of a Biomarker Present in Prostate Cancer Cells: New Insight into Therapeutic Benefit for Patients with Advanced Prostate Cancer
Date:7/17/2008

have a role in cell division and chromosome segregation, and we continued our quest to understand this potential function of PSMA," said Dr. Rajasekaran.

Human cells have 46 chromosomes. The chromosomes are vehicles that carry the genetic material DNA from generation to generation. These chromosomes are equally divided into daughter cells during cell division. Cells have several checkpoints to ensure that the chromosomes are equally separated during cell division. Anaphase-promoting complex (APC) is one such checkpoint regulatory protein involved in the proper segregation of chromosomes during cell division. This complex monitors the timing of cell division and provides sufficient time for cells to segregate chromosomes equally into daughter cells. Often, cancer cells have more than 46 chromosomes, a condition known as aneuploidy, which is a constant feature of aggressive, advanced, and drug-resistant solid tumors, including prostate cancer.

Rajasekaran and his research team found that PSMA-expressing cells spent less time dividing. They found that PSMA interferes with the function of APC and induces aneuploidy in cancer cells. "When PSMA is present, cells hurried to complete their division prior to having all their chromosomes properly segregated," said Dr. Sigrid A. Rajasekaran, the first author of the study and the head of the Cancer Cell Metabolism Laboratory at NCCCR.

PSMA is present in prostate cancer cells but not in normal cells. Therefore, it is an excellent therapeutic target for prostate cancer. There are several ongoing clinical trials for PSMA-based therapeutic interventions. "Since PSMA expression is higher in metastatic compared to benign cancer cells, anti-PSMA-based therapeutic strategies should target metastatic prostate cancer cells, which will benefit patients with advanced prostate cancer," the study states.

Dr. A. Rajasekaran and his team conducted their research on cell lines and are in the process of translating t
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SOURCE Nemours Center for Childhood Cancer Research
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