Navigation Links
Nektar Therapeutics Presents Positive Data from Human Abuse Liability Study for NKTR-181, a First-in-Class Investigational Opioid to Treat Chronic Pain, at 2013 Annual Meeting of The College on Problems of Drug Dependence
Date:6/19/2013

ain is important in abuse.  When we look at the critical period following dosing when the commonly abused drug oxycodone reaches maximum liking, NKTR-181 was not distinguished from placebo with respect to both drug-liking and feeling high.  These are two of the most important metrics that help us understand the abuse potential of a medicine.  Importantly, NKTR-181 was dosed as an oral liquid, which underscores that its less rewarding properties are inherent to this NCE and independent of any abuse-deterrent formulation.  These data, along with previous efficacy data, suggest NKTR-181 may be a major advance towards safer opioid therapy for the treatment of moderate to severe chronic pain."

The HAL study compared drug liking between each treatment group (oxycodone 40 mg, Placebo, and NKTR-181 100 mg, 200 mg, and 400 mg).  On the bipolar VAS scale (0-100), a score of 50 indicates that the subject "neither likes nor dislikes" the drug.  In the study, 40 mg of oxycodone oral solution resulted in a maximum mean drug liking score of 85, indicating a "strong liking" for the effects of oxycodone.  The oxycodone liking score was significantly different from placebo as early as 15 minutes after dosing and peaked at 60 minutes. In the placebo arm, the maximum mean drug liking score was 50, indicating that the subjects neither liked nor disliked the effects.  NKTR-181 dosing was similar to placebo with maximum mean drug liking VAS scores of 58, 58 and 63 for 100 mg, 200 mg and 400 mg, respectively.

"The data from this study are remarkable and clearly demonstrate that drug abusers could not discriminate NKTR-181 from placebo at doses that we know produced analgesia in the validated pain models from our Phase 1 studies," said Robert Medve MD, SVP and Chief Medical Officer of Nektar Therapeutics. "These data suggest that NKTR-181 could change the way we think about opioids and how we treat patie
'/>"/>

SOURCE Nektar Therapeutics
Copyright©2012 PR Newswire.
All rights reserved

Page: 1 2 3 4 5 6 7 8 9

Related medicine technology :

1. Nektar Presents Positive Preclinical Data for NKTR-214, a Novel Cancer Immunotherapy, At the 2013 American Society of Clinical Oncology Annual Meeting
2. Nektar Presents Target-Specific Biomarkers Being Assessed in Ongoing Phase 3 BEACON Study of Etirinotecan Pegol for the Treatment of Metastatic Breast Cancer at the 2013 American Society of Clinical Oncology Annual Meeting
3. Nektar Therapeutics President and CEO, Howard W. Robin, To Present at the Jefferies 2013 Global Healthcare Conference in New York City
4. Nektar Therapeutics President and CEO, Howard W. Robin, To Present at the 2013 UBS Global Healthcare Conference in New York City
5. Nektar Therapeutics Reports Financial Results for the First Quarter of 2013
6. Nektar to Announce Financial Results for the First Quarter of 2013 on Thursday, May 9, 2013, After Close of U.S.-Based Financial Markets
7. Nektar Therapeutics to Present at the 33rd Annual Cowen and Company Healthcare Conference in Boston
8. Nektar Therapeutics Reports Fourth Quarter and Year-End 2012 Financial Results
9. Nektar To Host Conference Call To Discuss The Positive Phase 3 Clinical Results For Naloxegol
10. Nektar Announces that FDA Grants Fast Track Designation to Etirinotecan Pegol (NKTR-102) for the Treatment of Metastatic Breast Cancer
11. Nektar to Announce Financial Results for the Third Quarter of 2012 On Tuesday, November 13, 2012, After Close of U.S.-Based Financial Markets
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/15/2014)... , Sept. 15, 2014 /PRNewswire-iReach/ -- MedicOne Medical ... transport services, has been selected by Inc. Magazine ... in America. Photo - ... 500|5000 list identifies successful, privately-held companies with the ... Medical Response, one of only two ambulance companies ...
(Date:9/15/2014)... , Sept. 15, 2014  Catalist-listed QT Vascular Ltd. ... a developer and manufacturer of minimally invasive medical devices ... announce that the Group has enrolled the first European ... . Multiple patients have already been enrolled in ... Auckland City Hospital, in Auckland, New Zealand ...
(Date:9/15/2014)... NEW YORK , Sept. 15, 2014 /PRNewswire/ ... together under one roof Saturday to learn, interact ... treatments at New York City,s first Lupus Trials Fair ... (LRI) and the S.L.E. Lupus Foundation . ... NYC,s leading institutions -- sharing experiences, ideas and ...
Breaking Medicine Technology:MedicOne Medical Response Named to 2014 Inc. 5000 Fastest Growing Companies List 2MedicOne Medical Response Named to 2014 Inc. 5000 Fastest Growing Companies List 3First European Patients Enrolled in QT Vascular's ENDURE Trial 2First European Patients Enrolled in QT Vascular's ENDURE Trial 3First European Patients Enrolled in QT Vascular's ENDURE Trial 4First European Patients Enrolled in QT Vascular's ENDURE Trial 5Lupus Research Institute Launches NYC's First Lupus Trials Fair 2Lupus Research Institute Launches NYC's First Lupus Trials Fair 3
(Date:9/16/2014)... Syracuse, NY (PRWEB) September 16, 2014 ... HearStrong Champion Danielle Strassle at the 2014 Buffalo Bills ... in Buffalo, NY. , Bills legend and NFL ... , assisted the foundation in honoring Strassle for her ... and professional goals and inspire others in her community ...
(Date:9/16/2014)... Online retailer Kettlebell Kings has announced that ... kettlebell purchases in their online store. The company wants ... with this effective workout method that is quickly gaining ... carries a variety of kettlebell brands as well as ... , “We’ve seen for ourselves how effective kettlebells ...
(Date:9/16/2014)... Yellow Spings, OH (PRWEB) September 16, 2014 ... the Master of Arts in Clinical Mental Health ... offering joins a growing list of programs offered through ... the spring semester starting January 2015. , "Antioch University ... a strong reputation in the field and a track ...
(Date:9/16/2014)... Issaquah, WA (PRWEB) September 16, 2014 ... of medical equipment and supplies and a veteran-owned ... lines for medical professionals-- Jant Pharmacal Corporation, Nipro ... is committed to providing its customers the best, ... serve its current customers, and in an effort ...
(Date:9/16/2014)... The Living Ethics lecture series returns ... on what it means to live in an ethically ... and thought-provoking topics. , “The Museum’s job is to ... at their world differently. The Living Ethics series’ ... truly enlightening dialogue,” says Richard Conti, Chief Wonder Officer, ...
Breaking Medicine News(10 mins):Health News:The HearStrong Foundation and the Buffalo Bills Alumni Foundation Celebrated HearStrong Champion During 2014 Alumni Weekend 2Health News:Join the Kettlebell Movement - Kettlebell Kings Announces $0 Shipping on all Orders 2Health News:Antioch University Launches Online Master’s Degree Program in Clinical Mental Health Counseling 2Health News:Expanding Community Vision at the Science Museum of Virginia 2
... A recent study finds that, TACE inhibitors currently developed ... control proliferation of tumor cells. TACE is// strongly present ... to current therapies. ,TACE (tumor necrosis factor-alpha-converting ... pair of ligands, called Amphiregulin and TGF-alpha, from the ...
... states have registered a leap in the number of dengue ... authorities fearing that the mosquito-borne// disease could further spread due ... ,The north-eastern state of Kelantan registered the highest jump, from ... cases in the first week of January. ...
... and Drug Administration has given the go-ahead to the ... otherwise called fat loss,// occurring in patients with AIDS ... assist in the manufacture of collagen. ,To ... on a study of 100 HIV patients suffering facial ...
... worried about the lack of natural B vitamin "folate" in ... has linked the inadequacy of this vitamin to birth defects ... to breads and cereals being supplemented with folic acid. This ... nation-wide study, undertaken between 1999 and 2004 showed that more ...
... by Jane Carlton, Ph.D., a parasite specialist and an associate ... University// School of Medicine, have successfully decoded the genome of ... STD that usually affects both men and women. ... of the journal Science. ,Moreover, this 4-year ...
... to a British Muslim scholar a special and specific health ... of Edinburgh University// believes that this could hold the key ... ,While sharing his thoughts in the British Medical Journal, professor ... realize this need and bring about a change in the ...
Cached Medicine News:Health News:A New Strategy to Control Breast Cancer 2Health News:Mosquito-borne Dengue Disease on the Rise in Five Malaysian States 2
3.2% Tryptone, 2.0% Yeast Extract, 0.5% Sodium Chloride, pH 7.5....
... radial head system employs the advantages of ... create the next generation of modular radial ... modular design, the implant system offers the ... patients anatomy. In addition, the capability of ...
For connection to the bipolar output of electrosurgical generators....
Recommended for use with spark gap coagulators for added safety. Also available in stainless steel (10-3002)....
Medicine Products: