Navigation Links
Nektar Therapeutics Presents Positive Data from Human Abuse Liability Study for NKTR-181, a First-in-Class Investigational Opioid to Treat Chronic Pain, at 2013 Annual Meeting of The College on Problems of Drug Dependence
Date:6/19/2013

SAN DIEGO, June 19, 2013 /PRNewswire/ -- Nektar Therapeutics (Nasdaq: NKTR) today announced positive top-line results from a human abuse liability (HAL) study for NKTR-181, a first-in-class, opioid analgesic molecule with a slow rate of entry into the brain.  This slow rate of entry is designed to reduce the euphoria that can lead to the abuse of and addiction to current opioid analgesics.1 In the study data being presented today, NKTR-181 was rated similar to placebo in "drug liking" and "feeling high" scores and had highly statistically significant lower "drug liking" scores and reduced "feeling high" scores as compared to oxycodone at all doses tested (p<0.0001).Prescription opioids are critical in the management of moderate-to-severe chronic pain.  However, the abuse and misuse of these opioids have led to a serious public health crisis.
HAL studies are clinical studies that assess the relative abuse potential of a medicine.  These studies are conducted in a non-dependent, recreational drug abuser population and are designed to predict how probable it is that a particular medicine will be attractive to abusers (i.e., "liked").  The primary endpoint for the NKTR-181 HAL study was drug-liking measured on a bi-polar visual analogue scale (VAS).  This endpoint is known to correlate most directly with a drug's potential for abuse.2

"It is clear that there is a pressing societal need for better and safer analgesics," said Dr. Lynn Webster, President of the American Academy of Pain Medicine and lead investigator for the study at CRI Lifetree. "We know that speed of entry into the br
'/>"/>

SOURCE Nektar Therapeutics
Copyright©2012 PR Newswire.
All rights reserved

Page: 1 2 3 4 5 6 7 8 9

Related medicine technology :

1. Nektar Presents Positive Preclinical Data for NKTR-214, a Novel Cancer Immunotherapy, At the 2013 American Society of Clinical Oncology Annual Meeting
2. Nektar Presents Target-Specific Biomarkers Being Assessed in Ongoing Phase 3 BEACON Study of Etirinotecan Pegol for the Treatment of Metastatic Breast Cancer at the 2013 American Society of Clinical Oncology Annual Meeting
3. Nektar Therapeutics President and CEO, Howard W. Robin, To Present at the Jefferies 2013 Global Healthcare Conference in New York City
4. Nektar Therapeutics President and CEO, Howard W. Robin, To Present at the 2013 UBS Global Healthcare Conference in New York City
5. Nektar Therapeutics Reports Financial Results for the First Quarter of 2013
6. Nektar to Announce Financial Results for the First Quarter of 2013 on Thursday, May 9, 2013, After Close of U.S.-Based Financial Markets
7. Nektar Therapeutics to Present at the 33rd Annual Cowen and Company Healthcare Conference in Boston
8. Nektar Therapeutics Reports Fourth Quarter and Year-End 2012 Financial Results
9. Nektar To Host Conference Call To Discuss The Positive Phase 3 Clinical Results For Naloxegol
10. Nektar Announces that FDA Grants Fast Track Designation to Etirinotecan Pegol (NKTR-102) for the Treatment of Metastatic Breast Cancer
11. Nektar to Announce Financial Results for the Third Quarter of 2012 On Tuesday, November 13, 2012, After Close of U.S.-Based Financial Markets
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/17/2014)... , Alemania, December 17, 2014 ... año anterior, con un alto nivel de gasto en ... año fiscal 2013/14 (finalizado el 30 de septiembre de ... ciento a 4.287 millones de euros (año anterior: 4.190 ... la moneda desfavorables. Las ganancias (EBIT) crecieron un 14 ...
(Date:12/17/2014)... NEW YORK , Dec. 17, 2014 /PRNewswire-USNewswire/ ... resonance imaging (MRI), the MRI market is seeing ... cardiovascular and breast MRI scans account for the ... providing a higher resolution of images, which are creating ... resonance imaging (MRI) market is growing at a ...
(Date:12/17/2014)... , Dec. 17, 2014  IGI Laboratories, Inc. (NYSE ... closing of its offering of $125 million aggregate principal ... "Notes").  The Notes were offered and sold only to ... Securities Act of 1933, as amended (the "Securities Act"). ... rate of 3.75% per year, payable semiannually in arrears ...
Breaking Medicine Technology:ZEISS confirma su posición en un entorno difícil 2Kalorama: 3T Advancements Bringing New Growth to the MRI Market 2Kalorama: 3T Advancements Bringing New Growth to the MRI Market 3IGI Laboratories Announces Closing of $125 Million of 3.75% Convertible Senior Notes Due 2019 2IGI Laboratories Announces Closing of $125 Million of 3.75% Convertible Senior Notes Due 2019 3IGI Laboratories Announces Closing of $125 Million of 3.75% Convertible Senior Notes Due 2019 4
... both ethical and practical grounds, direct programming is ... pluripotent stem,cells.", WASHINGTON, Nov. 20 Two ... Cell unveil a proven way to,generate patient-matched human ... use of human embryos or human or animal ...
... of circulating cancer cells in 40,billion blood cells, ... WARREN, N.J., Nov. 20 Veridex, LLC ... (FDA) has granted an,expanded clearance for the CellSearch(TM) ... monitoring of metastatic colorectal cancer. CellSearch is currently,approved ...
Cached Medicine Technology:Two Major Studies Show: Human Pluripotent Stem Cells without Cloning or Destroying Embryo 2Two Major Studies Show: Human Pluripotent Stem Cells without Cloning or Destroying Embryo 3FDA Clears Advanced Test for Monitoring Metastatic Colorectal Cancer 2FDA Clears Advanced Test for Monitoring Metastatic Colorectal Cancer 3FDA Clears Advanced Test for Monitoring Metastatic Colorectal Cancer 4
(Date:12/20/2014)... Dress company LunaDress has recently announced its 2015 ... offering big discounts on all of its special occasion dresses ... own a perfect wedding gown. If you have no idea ... to LunaDress. Many different wedding dress styles and our dress ... and enjoy the current special offer, up to 80% off," ...
(Date:12/20/2014)... December 20, 2014 Recently, VogueQueen.com, a ... VogueQueen Big Sale Online for 2015. Great ... All new and old consumers can get a discount, ... at the company’s website before January 30, 2015. , ... dresses and launched a prom dress promotion. Many customers ...
(Date:12/20/2014)... 20, 2014 Atore, Inc, (San Francisco, ... launched first birthday focused portal on December 17th, 2014. ... launched in both US and Japan. , MERRY BIRTHDAY ... http://merrybirthday.net/message/ , MERRY BIRTHDAY MESSAGE is part ... the world. , Features, Choose from thousands of stock ...
(Date:12/20/2014)... Xarelto bleeding lawsuits filed by men and ... other serious side effects will be consolidated in the ... pretrial proceedings, Wright &amp;amp; Schulte LLC reports. The U.S. ... Friday to transfer 21 Xarelto lawsuits and over 30 ... the Louisiana district court for coordination by Judge Eldon ...
(Date:12/19/2014)... Today, Balfleet.com , a leading dress ... formal dress promotion. All the old and new customers ... , Balfleet.com is well-known for its high quality trendy ... cocktail dresses and more. Its formal dresses are quality ... they can create an elegant look when paired with ...
Breaking Medicine News(10 mins):Health News:2015 Collection of Wedding Dresses from LunaDress Online on Sale Now 2Health News:VogueQueen Big Sale Online For The Coming 2015 2Health News:Atore, Inc. Releasing the First Birthday Portal 2Health News:Xarelto Bleeding Lawsuits Consolidated To Louisiana Federal Court For Multi-District Litigation Reports Wright & Schulte LLC 2Health News:Xarelto Bleeding Lawsuits Consolidated To Louisiana Federal Court For Multi-District Litigation Reports Wright & Schulte LLC 3Health News:Xarelto Bleeding Lawsuits Consolidated To Louisiana Federal Court For Multi-District Litigation Reports Wright & Schulte LLC 4Health News:Balfleet.com Announces Its Formal Dress Promotion For 2015 2
... The Speaker of Lok Sabha, Shri Somnath Chatterji has said ... priority in policy making and implementation of programmes. // ... the country and the children at Vaatsalaya Mela here today, ... that still women and children went struggling for their rightful ...
... certain inhaled asthma medications and similar chemicals produced in ... worsen conditions like lupus, heart failures, asthma and other ... led by Raymond Penn, Ph.D., and Matthew Loza, Ph.D, ... out the research, found that beta-agonists, such as those ...
... engaging people cured of leprosy to fight the stigma of the ... of leprosy in the state has fallen to 1.56 percent in ... 'Lok Doots' (Messenger of People), as the cured are called, have ... ,For instance, the prevalence rate in Ranchi has gone up ...
... cardiac arrest is a common and deadly event. Twenty percent of ... a sudden cardiac arrest; //barely 5% of people who have one ... comes out of the blue, but a new study suggests that ... 2006 issue of the Harvard Heart Letter. ,Studying cardiac arrest ...
... The Massachusetts Biologic Laboratories (MBL) of the University of ... India today announce //the formation of an historic collaboration ... approach for preventing rabies in people. ,The institutions ... antibody (MAB) created by scientists at the MBL, in ...
... often multi-tasking and walking the tightrope to make a success ... they can chew! Though, such qualities //are the epitome of ... a pat on the back for such back-breaking endeavors. ... ill-health due to the build up of stress and over ...
Cached Medicine News:Health News:Women and Children Issues Should Get Priority in India 2Health News:The Immune System May Be Altered By Certain Chemicals 2Health News:International Collaboration Takes Aim at Rabies 2Health News:International Collaboration Takes Aim at Rabies 3
... Heartlab delivers the performance and ... information management systems. As the ... services set the benchmark. When ... high-speed performance and technological longevity, ...
The only catheter designed specially for visualization of peripheral vessels: carotids, renals, and illiacs...
... technology constructs images using second harmonic ... and noise than fundamental-frequency components., Pure ... transmit distortion-free, fundamental-frequency ultrasound beams. And ... a pure sinusoidal wave, both the ...
AngioSpeed V series, it is an Angiography system designed for vascular treatment in various radiological regions, cardiology, and neurology. SHIMADZU brings you a single system with all units fused t...
Medicine Products: