Navigation Links
Nektar Presents Positive Proof-of-Concept Clinical Data for Its New Opioid Molecule, NKTR-181, at American Academy of Pain Medicine's 28th Annual Meeting
Date:2/27/2012

SAN FRANCISCO, Feb. 27, 2012 /PRNewswire/ -- Nektar Therapeutics (Nasdaq: NKTR) today announced a presentation of positive clinical data for NKTR-181, its new oral opioid analgesic molecule, at the 2012 American Academy of Pain Medicine's 28th Annual Meeting (AAPM). NKTR-181 is a novel mu-opioid agonist molecule, which was designed to have a slow rate of entry into the brain to reduce the attractiveness of the molecule as a target of abuse and to reduce its CNS-mediated side effects. NKTR-181 was created using Nektar's proprietary polymer conjugate technology and its differentiating properties are inherent to the design of the new molecule.  As a new molecular structure, NKTR-181 is unique in that it does not rely on a formulation approach to prevent its conversion into a more abusable form of an opioid.

Clinical results were presented at AAPM from a human Phase 1 study which evaluated the pharmacokinetics, pharmacodynamics, and safety of oral doses of NKTR-181 as compared to placebo over an 8-day treatment period in healthy subjects.  Using pupil constriction as a measure of the onset of central opioid effect, the study showed that NKTR-181 enters the brain slowly and produces centrally-mediated opioid effects that are dose-dependent and statistically meaningful (P<0.001) following twice daily oral doses of 200-400 mg.  Further, NKTR-181 enters the CNS from the plasma at a rate approximately ten-times slower than historical published rates for oxycodone.(1)  NKTR-181's slow rate of entry into the CNS may reduce the euphoria and other CNS side effects that are associated with rapid CNS uptake of current standard opioid therapies. 

"NKTR-181 is an exciting new approach to opioid analgesia," said Lynn R. Webster, MD, Medical Director of Lifetree Clinical Research. "The human data now show us that NKTR-181 crosses into the brain slowly across
'/>"/>

SOURCE Nektar Therapeutics
Copyright©2010 PR Newswire.
All rights reserved

Page: 1 2 3 4 5 6 7 8 9 10

Related medicine technology :

1. Nektar to Announce Financial Results for the Fourth Quarter and Year-End of 2011 on Wednesday, February 29, 2012, After Close of U.S.-Based Financial Markets
2. Positive Data for Nektars New Mu-Opioid Analgesic Molecule to Treat Acute Pain Highlighted at Neuroscience 2011
3. Nektar Therapeutics Reports Third Quarter 2011 Financial Results
4. Nektar to Announce Financial Results for the Third Quarter of 2011 on Wednesday, November 2, 2011, After Close of U.S.-Based Financial Markets
5. Nektar Therapeutics President and CEO, Howard W. Robin, to Present at the UBS 2011 Global Life Sciences Conference in New York City
6. Nektar Initiates Second Phase 1 Clinical Study Evaluating NKTR-181, A Novel Opioid Molecule, for Treatment of Chronic Pain
7. Nektar Therapeutics Reports Second Quarter 2011 Financial Results
8. Nektar to Announce Financial Results for the Second Quarter of 2011 on Thursday, August 4, 2011, After Close of U.S.-Based Financial Markets
9. Nektar Therapeutics President and CEO Howard W. Robin to Present at the Jefferies 2011 Global Healthcare Conference in New York
10. Nektar Announces New Phase 2 Data for NKTR-102 to Be Presented at 2011 ASCO Annual Meeting
11. FDA Grants Orphan Drug Designation for Nektars Investigational Drug, NKTR-102, for Treatment of Women with Ovarian Cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/2/2015)... -- BGI a annoncé aujourd,hui que son laboratoire ... à Hong Kong avait ...  (Collège des pathologistes américains, ou CAP). Les installations ... constituent le premier laboratoire clinique de séquençage ... CAP en Chine, car il satisfait les normes ...
(Date:7/2/2015)... 2, 2015  New product launches are critical events ... in educating thought leaders about new products, Medical Affairs ... how well a new therapy performs at launch. ... and consulting leader Best Practices, LLC, critical aspects of ... on are early stage thought leader (TL) interaction, successful ...
(Date:7/2/2015)... 2, 2015 Roche,s Bloodhound technology is ... segment in hematology testing, according to Kalorama Information.  ... unveiling of its Bloodhound digital cell imaging technology ... 511 hematology analyzer – is notable as ... by current leader CellaVision, but also compete more ...
Breaking Medicine Technology:BGI obtient la certification du Collège des pathologistes américains (CAP) 2Medical Affairs Role in Thought Leader Education is Key Success Factor for New Product Launches in the Pharmaceutical Industry 2Kalorama: With Bloodhound, Roche Closes in on High-Growth Hematology Segment 2Kalorama: With Bloodhound, Roche Closes in on High-Growth Hematology Segment 3
... today visited the future site of Endo Pharmaceutical,s corporate headquarters ... continued commitment to the region and its plans to create ... Pennsylvania we are employing the kind of creative cooperation that ... ribbon on a new headquarters," said Corbett. "This investment in ...
... FISHKILL, N.Y., Jan. 17, 2012  Nano Mask, Inc. (NMI) (Pink ... company focused on emergency and critical care as well as ... sales, marketing and distribution office in Riyadh, Saudi Arabia to ... into the strong demand for its products in the region. ...
Cached Medicine Technology:Nano Mask Opens Office in Riyadh, Saudi Arabia Due to Strong Demand for Company's Products 2
(Date:7/3/2015)... , ... July 04, 2015 , ... The Harvest Hope Food Bank will ... Four local AlignLife offices in the area of Greenville SC are making it ... be made by patients only. They are asking for donations from the public as well. ...
(Date:7/3/2015)... ... 03, 2015 , ... Renowned rhinoplasty surgeon and Symposium Chairman, ... Rhinoplasty Symposium . To be held from March 4th - 6th, the 2016 (a ... Westin Galleria Dallas. , Designed to take participants from the basic training and fundamentals ...
(Date:7/3/2015)... ... July 03, 2015 , ... Talcum powder attorneys representing clients in ... Talcum Powder Cancer Lawsuit Center website. Just as the previous version did, the new ... offering timely lawsuit updates and ovarian cancer warning information. The site is routinely updated ...
(Date:7/3/2015)... ... July 03, 2015 , ... Every year, One-to-1 Fitness and the ... members of the Red Deer community with free fitness training and indoor fitness boot ... food, events and entertainment raised thousands of charity dollars and ended with a $10,000 ...
(Date:7/2/2015)... (PRWEB) , ... July 02, 2015 , ... Following the ... stated the number of obese Americans outnumber merely overweight Americans, Samir Becic emphatically declared ... biggest threats to American society right now," Becic said. "We must understand the magnitude ...
Breaking Medicine News(10 mins):Health News:Greenville Area AlignLife Offices to do a Thanksgiving in July Food Drive 2Health News:Greenville Area AlignLife Offices to do a Thanksgiving in July Food Drive 3Health News:Dr. Rod J. Rohrich Announces the Dates for 2016 Dallas Rhinoplasty Symposium 2Health News:Dr. Rod J. Rohrich Announces the Dates for 2016 Dallas Rhinoplasty Symposium 3Health News:Talcum Powder Lawsuit News: Cancer Attorneys Launch Updated Mobile Site 2Health News:Talcum Powder Lawsuit News: Cancer Attorneys Launch Updated Mobile Site 3Health News:Red Deer Fitness Studio Raises $10,000 for Charity Organization with 24-Hour Train-a-Thon 2Health News:Red Deer Fitness Studio Raises $10,000 for Charity Organization with 24-Hour Train-a-Thon 3Health News:Samir Becic's Health Fitness Revolution Declares War Against Obesity in America 2Health News:Samir Becic's Health Fitness Revolution Declares War Against Obesity in America 3Health News:Samir Becic's Health Fitness Revolution Declares War Against Obesity in America 4
... -- A new analysis confirms that those who take the ... and die than those who take a similar type of ... considerable," the analysis authors wrote. Avandia (rosiglitazone) helps control ... patients with type 2 diabetes. Studies in recent years have ...
... March 16 (HealthDay News) -- Tooting another,s horn may ... school,s band, a new study suggests. Researchers tested ... found they were heavily contaminated with different kinds of ... minor to serious infections and allergic diseases. The ...
... 17, 2011 -- The increase in the number of ... is a positive sign toward easing the primary care ... (ACP), the nation,s second-largest doctors group. The 2011 ... 8.0 percent increase from last year, with 2,940 U.S. ...
... (HealthDay News) -- Many American children who qualify for ... because their parents are confused about enrollment and eligibility, ... in 10,175 low-income households in Oregon and found that ... Stamp Program were not enrolled in the Oregon Health ...
... Texas A&M University and Texas State University found that ... likely to eat their veggies. The report, published in ... adults aged 50+ and includes recommendations for promoting gardening ... Aime Sommerfeld, Amy McFarland, Tina Waliczek, and Jayne Zajicek, ...
... that could help them track how effectively the immune system ... forms the plaques considered one of the hallmarks of Alzheimer,s ... the Journal of Alzheimer,s Disease , demonstrates how the ... is expressed differently in different Alzheimer,s patients. The finding may ...
Cached Medicine News:Health News:Analysis Confirms Avandia May Harm the Heart 2Health News:Residency match results encouraging for adults needing primary care 2Health News:Parents Often Confused About Kids' Health Coverage 2Health News:Gardening linked to increased vegetable consumption in older adults 2Health News:Scientists ID possible biomarker to gauge Alzheimer's prognosis, effect of therapies 2Health News:Scientists ID possible biomarker to gauge Alzheimer's prognosis, effect of therapies 3Health News:Scientists ID possible biomarker to gauge Alzheimer's prognosis, effect of therapies 4
Cruciate Retaining, Posterior Stabilized and Constrained Components....
... posterior stabilized knee has an advanced ... flange mates with both resurfacing and ... precise, repeatable kinematics and fit with ... reduce wear. Constant cutting guide peg ...
... system is a long term, ... clinically proven design. Available in ... correct cruciate retaining configurations. In ... of identification keeps the user ...
... System was designed to replicate normal ... has a recessed, deepened and extended ... the patella, which has been shown ... groove promotes more normal kinematics and ...
Medicine Products: