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Nektar Presents Positive Preclinical Data for NKTR-214, a Novel Cancer Immunotherapy, At the 2013 American Society of Clinical Oncology Annual Meeting
Date:6/3/2013

SAN FRANCISCO, June 3, 2013 /PRNewswire/ -- Nektar Therapeutics (NASDAQ: NKTR) announced positive preclinical data for NKTR-214, an investigational cancer immunotherapy which targets the IL-2 receptor complex and is being developed as a potential treatment for multiple cancers. The results were presented today at the 2013 ASCO Annual Meeting in Chicago.  NKTR-214 targets the IL-2 receptor complex through selective receptor binding to the IL2R beta subtype.  Activation of the IL2R beta subtype promotes tumor killing by the body's own immune system.

"The design of NKTR-214 provides dramatic efficacy in an aggressive and resistant preclinical model of melanoma, despite dosing 10-fold less cytokine at a significantly lower dosing frequency as compared to standard aldesleukin dosing," said Stephen Doberstein , Ph.D., Senior Vice President and Chief Scientific Officer of Nektar Therapeutics.  "The ability to dial back the dose intensity with NKTR-214 results in a potentially safer therapy while still increasing efficacy. The reduced dosing frequency also makes it amenable to combination with other immunotherapies such as immune checkpoint inhibitor antibodies." 

NKTR-214 is a novel immunocytokine therapy that is engineered using Nektar's polymer conjugate technology to selectively target the beneficial IL-2 receptor complex.  NKTR-214 maintains high affinity for the IL-2 receptor subunit beta, which activates tumor-killing T-cells within the tumor microenvironment.  At the same time, NKTR-214 exhibits up to 100-fold reduced affinity to the IL-2 receptor subunit alpha-beta, which is designed to minimize the immunosuppressive effects that normally limit the efficacy of standard aldesleukin.  In the preclinical data presented at ASCO, NKTR-214 exhibits effi
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