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Nektar Presents New Preclinical Data on NKTR-181 at Anesthesiology 2010
Date:10/17/2010

primates that are used to predict abuse liability of compounds, NKTR-181 showed a marked reduction in self-administration of drug as compared to both oxycodone and morphine.  Additionally, in a series of in situ brain perfusion studies, NKTR-181 exhibited a significantly reduced rate of entry into the CNS as compared to oxycodone.  

These data were presented at Anesthesiology 2010: American Society of Anesthesiologists Annual Meeting during the poster session entitled "Chronic and Cancer Pain":

  • Fishburn et al., "NKTR-181, a Novel Opioid Analgesic with Slow Entry into the CNS and Markedly Reduced CNS Side Effects" (Abstract A509), October 17, 2010, 9:00 – 11:00 AM Pacific time, Room Hall B1-Area G.

  • The poster presentation can be found on Nektar's website at www.nektar.com.

    About Opioids and Pain ManagementPain is the most common symptom for which patients seek medical attention.(1)  According to the American Pain Society, the prevalence of chronic pain in the United States is estimated to be 35.5% or 105 million people.  Chronic pain costs more than $100 billion per year in direct health-care expenditures and lost work time. Opioids are considered to be the most effective therapeutic option for pain and have over $10 billion a year in sales in the U.S. alone.(2,3)  However, opioids cause significant problems for physicians and patients because of their serious side effects such as respiratory depression and sedation, as well as the risks they pose for addiction, abuse, misuse, and diversion. The U.S. Food and Drug Administration has cited prescription opioid analgesics as being at the center of a major public health crisis of addiction, misuse, abuse, overdose and death.(4)  A 2010 recent report from the Center for Disease Control and Prevention (CDC) notes that emergency room visits tied to the abuse of prescription painkillers is at an all-t
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    SOURCE Nektar Therapeutics
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