Navigation Links
Nektar Presents New Preclinical Data on NKTR-181 at Anesthesiology 2010
Date:10/17/2010

SAN CARLOS, Calif., Oct. 17 /PRNewswire/ -- Nektar Therapeutics (Nasdaq: NKTR) today presented new preclinical data demonstrating that NKTR-181, a mu-opioid analgesic with a novel molecular structure, dramatically reduces abuse liability while providing analgesia comparable to oxycodone and morphine.  These data were presented during the poster session entitled "Chronic and Cancer Pain" held today at the American Society of Anesthesiologists (ASA 2010) Annual Meeting on October 17, 2010 in San Diego, CA.

NKTR-181 was uniquely designed to cross the blood-brain barrier at a substantially slower rate than other opioid therapies.  With a reduced rate of entry into the CNS, NKTR-181 has the potential to eliminate not only the euphoria that underlies opioid abuse liability and dependence but also the serious CNS-related side effects of respiratory depression and sedation. The unique molecular design of the polymer drug conjugate also prevents conversion of NKTR-181 by the user into a rapid-acting abusable form of an opioid.  NKTR-181 is currently in IND-enabling studies and Nektar plans to begin Phase 1 clinical studies in the first part of 2011.  

"New therapeutics to manage chronic pain without the serious risks associated with existing opioids are desperately needed," said Lynn R. Webster, MD, Medical Director of Lifetree Clinical Research and Pain Clinic and President, Utah Academy of Pain Medicine.  "A novel opioid therapy, such as NKTR-181, with low abuse potential and fewer CNS-related side effects than existing opioids provides great promise for pain practitioners looking for safer, more effective pain management."

NKTR-181 Data Highlights from ASA 2010In a preclinical in vivo model of pain, NKTR-181 showed comparable analgesic efficacy to both oxycodone and morphine.   In self-administration studies in non-human
'/>"/>

SOURCE Nektar Therapeutics
Copyright©2010 PR Newswire.
All rights reserved

Page: 1 2 3 4 5

Related medicine technology :

1. Nektar Commences Phase 2 Clinical Development Program for NKTR-102 (PEG-Irinotecan) in Colorectal Cancer
2. Nektar Commences Phase 2 Trial of NKTR-118 (oral PEG-naloxol) Evaluating Efficacy and Safety as Treatment for Opioid-Induced Bowel Dysfunction
3. Nektar Terminates All Negotiations With Potential Partners for Inhaled Insulin; Increased Number of Lung Cancer Cases Observed in Ongoing Clinical Studies of Inhaled Insulin Patients
4. Nektar Therapeutics to Present Positive Data at Upcoming Medical and Scientific Meetings
5. Nektar to Webcast Presentation of Phase 1 Clinical Results for Lead Small Molecule PEG-Oncolytic Program, NKTR-102 (PEG-irinotecan)
6. Nektar Announces Expanded Phase 2 Clinical Development Plan For NKTR-102 (PEG-irinotecan)
7. Nektar Announces Positive Results from Phase 2 Study of Oral NKTR-118 in Patients with Opioid-Induced Constipation (OIC)
8. Nektar Therapeutics Reports Second Quarter 2009 Financial Results
9. Nektar Presents Data Demonstrating Favorable Oral Bioavailability and Drug-Drug Interaction Profile for NKTR-118
10. Nektar Therapeutics Promotes Lorianne Masuoka, M.D. to Senior Vice President and Chief Medical Officer
11. Genaera Corporation Presents Interim Phase 1 Data for Obesity Compound Trodusquemine (MSI-1436) at IBC Conference
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/14/2014)... 14, 2014 InformEx, North America,s ... chemistry, will hold the 30 th edition of its ... Convention Center from January 21-24. (Logo: http://photos.prnewswire.com/prnh/20131028/NY05330LOGO-a ... pharmaceutical, fine chemical and specialty chemical companies will take part ...
(Date:1/14/2014)... , Jan. 14, 2014 Animal Emergency Critical Care, a ... Leesburg, Virginia is the first in ... chamber. Dr. Susan M. Barnes , Medical ... Barnes and husband, Dr. Cole Taylor , are avid scuba ...
(Date:1/14/2014)... , January 14, 2014 ... Transfer Devices (CSTD) for hazardous drugs, today announced that it ... fourth straight year.   Equashield,s closed ... technicians, pharmacists, nurses and other medical professionals who ...
Breaking Medicine Technology:Media Advisory: InformEx 2014 Events & Speaker Lineup for 30th Edition Conference in Miami Beach 2Hyperbaric Veterinary Medicine (hvm) Announces Animal Emergency Critical Care Installs A Small Animal Hyperbaric Chamber 2Equashield's Sales Grow by 60% in 2013 2
... 9 BioCryst Pharmaceuticals, Inc. (Nasdaq: BCRX ) today ... the Company,s Board of Directors. Dr. Sanders brings to ... and professor of medicine. , "We are pleased ... Zola P. Horovitz, Ph.D., Chairman of the Board of BioCryst ...
... , LONDON, Dec. 9 ... $1 billion in the European Union (EU), which includes total ... anticholinergics used for disease symptom relief. With the introduction of ... guidelines that call for using dopamine agonists as first-line therapy, ...
Cached Medicine Technology:BioCryst Pharmaceuticals Elects Charles A. Sanders to its Board of Directors 2BioCryst Pharmaceuticals Elects Charles A. Sanders to its Board of Directors 3BioCryst Pharmaceuticals Elects Charles A. Sanders to its Board of Directors 4Drug Candidates in Pipeline Offer Potential for Parkinson's Disease Therapeutics Market, Says Frost & Sullivan 2Drug Candidates in Pipeline Offer Potential for Parkinson's Disease Therapeutics Market, Says Frost & Sullivan 3
(Date:7/9/2014)... occurrence of allergic diseases has risen dramatically in Western ... less exposed to microorganisms and have fewer infections than ... , A study by researchers at Sahlgrenska Academy, University ... to examine maturation of the immune system in relation ... rural areas of the Vstra Gtaland Region, half of ...
(Date:7/8/2014)... UCLA Program in Memory Restoration has been awarded up ... Agency (DARPA) for a four -year project aiming to ... team of experts in neurosurgery, engineering, neurobiology, psychology and ... a memory prosthesis in the brain. , Memory is ... the brain encode information, store it and retrieve it. ...
(Date:7/8/2014)... hygiene rates were found to be three times higher ... there were no auditors present, according to a study ... The study, titled, "Quantification of the Hawthorne effect in ... a retrospective cohort study," published today on-line in the ... author Dr. Jocelyn Srigley, who did the study as ...
(Date:7/8/2014)... have increased risks of dying at a young age ... stroke, diabetes, and kidney and liver diseases, according to ... large studies of people from three countries. The study, ... part of the National Institutes of Health, found that ... dramatic reduction in life expectancy compared with people of ...
(Date:7/8/2014)... LOUIS Military physicians will soon pick up joysticks instead ... children with serious health threats. , James Gerard, M.D., a ... $541,807 grant from the Department of Defense Office of ... develop a video game that will train physicians on pediatric ... to use one of the most popular tools gaming ...
Breaking Medicine News(10 mins):Health News:DARPA awards UCLA $15 million to restore lost memory 2Health News:DARPA awards UCLA $15 million to restore lost memory 3Health News:Health-care worker hand hygiene rates increase three-fold when auditors visible 2Health News:Health-care worker hand hygiene rates increase three-fold when auditors visible 3Health News:NCI study finds extreme obesity may shorten life expectancy up to 14 years 2Health News:Save, don't kill: SLU pediatrician to develop educational video game for training military physician 2
... MONDAY, Dec. 19 (HealthDay News) -- When it comes to toys, ... for parents, who find themselves asking two crucial questions. The ... safe for my child? And the second, though not as ... media aimed at spurring a child,s development: Which of these toys ...
... EDITOR,S PICK: Potential concern about drugs in clinical trial ... derived naturally in the body from a major component ... [EETs]) are currently in clinical trials for the treatment ... researchers led by Dipak Panigrahy and Mark Kieran, ...
... COLUMBUS, Ohio -- Drinking enough alcohol to become intoxicated increases ... according to new research. But people without that trait ... when they,re sober. That trait is the ability to ... focus on the here and now, without thinking about the ...
... 19 (HealthDay News) -- Knee pain is common in middle-aged and ... of data collected from nearly 500 women, ages 44 to 57, ... older reported persistent, incident or intermittent knee pain. Forty-four percent ... percent said they had knee pain on most days of the ...
... Known for her poetry, letters, love affair and marriage ... legacy of unanswered questions about her lifelong chronic illness. ... her daughter, may have unraveled the mystery. Born in ... weakness, heart palpitations, intense response to heat and cold, ...
... better quality of life (QOL) and diminished cardiovascular disease ... adenotonsillectomy, according to new research published in the December ... Surgery . SDB is an increasingly common ... apnea syndrome (OSAS). Cardiovascular (CV) disease frequently has been ...
Cached Medicine News:Health News:Discerning Gift-Givers Look for Toys That Offer More Than Fun 2Health News:Discerning Gift-Givers Look for Toys That Offer More Than Fun 3Health News:Discerning Gift-Givers Look for Toys That Offer More Than Fun 4Health News:JCI online early table of contents: Dec. 19, 2011 2Health News:JCI online early table of contents: Dec. 19, 2011 3Health News:JCI online early table of contents: Dec. 19, 2011 4Health News:JCI online early table of contents: Dec. 19, 2011 5Health News:JCI online early table of contents: Dec. 19, 2011 6Health News:JCI online early table of contents: Dec. 19, 2011 7Health News:1 trait has huge impact on whether alcohol makes you aggressive 2Health News:1 trait has huge impact on whether alcohol makes you aggressive 3Health News:Knee Pain Plagues Many Women Over 50 2Health News:Elizabeth Barrett Browning's illness deciphered after 150 years 2Health News:Elizabeth Barrett Browning's illness deciphered after 150 years 3Health News:Effect of adenotonsillectomy in children with sleep-disordered breathing 2
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
Medicine Products: