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Nektar Announces Start of Enrollment in Phase 2 Study of NKTR-181, a Novel Opioid Analgesic Molecule, for Treatment of Chronic Pain
Date:7/24/2012

udy include quality-of-life assessment, sleep and motor activity scoring, as well as tolerability endpoints. 

The company is also planning a separate human abuse liability study for NKTR-181 as part of Phase 2 development for the compound. This study will measure liking scores for NKTR-181 as compared to an active opioid in approximately 20 recreational drug users.

About Opioids and Pain Management
Pain is one of the most common reasons people seek medical treatment.1 The American Pain Society estimates that 35.5 percent of the U.S. population, or 105 million people, suffer from chronic pain in the United States. Chronic pain conditions, such as osteoarthritis, back pain and cancer pain, affect at least 126 million adults in the U.S. annually and contribute to over $100 billion a year in direct healthcare expenditures and lost work time.1 Opioids are considered the most effective therapeutic option for pain, with sales exceeding over $10 billion a year in the U.S. alone.2,3 However, opioids can cause serious side effects such as respiratory depression and sedation and have the potential for addiction, abuse and misuse. In 2010, the Centers for Disease Control and Prevention reported that emergency room visits for non-medical use of opioid analgesics increased 111 percent over a five-year period.4

About Nektar
Nektar Therapeutics is a biopharmaceutical company developing novel therapeutics based on its PEGylation and advanced polymer conjugation technology platforms.  Nektar has a robust R&D pipeline of potentially high-value therapeutics in oncology, pain and other therapeutic areas. In the area of pain, Nektar has an exclusive worldwide license agreement with AstraZeneca for naloxegol (NKTR-118), an investigational drug candidate, which is being evaluated in Phase 3 clinical studies as a once-daily, oral tablet for the treatment of opioid-induced constipation.  This agr
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SOURCE Nektar Therapeutics
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