Navigation Links
Naurex Inc. Initiates Phase I Clinical Trial of its Novel Mechanism NMDA Modulator GLYX-13 in Treatment-Resistant Depression
Date:12/16/2009

bserved and laboratory-confirmed safety. Drug pharmacokinetics will also be measured.

The efficacy of NMDA receptor glycine site functional partial agonists has been demonstrated in animal models and early human studies in a number of CNS disorders, including major depressive disorder, neuropathic pain, schizophrenia, anxiety, Alzheimer's disease and other cognition disorders. In these studies, GFPA modulators did not exhibit the psychosis-like side effects associated with NMDA receptor blockers that interact with other binding sites on the receptor complex. GLYX-13 has demonstrated a wide therapeutic ratio (500:1) between efficacy and side effects, which is the largest therapeutic ratio of any reported molecule that interacts at the NMDA receptor.

For more information about the GLYX-13 Phase I trial, see www.clinicaltrials.gov .

About Naurex

Naurex, Inc. is a private company developing novel therapies for depression and other CNS disorders based on the work of founder Dr. Joseph R. Moskal and colleagues now at The Falk Center for Molecular Therapeutics at Northwestern University, who discovered a new mechanism of action for modulating the NMDA receptor. Naurex has used these discoveries to generate novel chemical drug classes known as glycine site functional partial agonists (GFPAs). Naurex's first GFPA NMDA modulator, GLYX-13, has shown promising signs of antidepressant activity with excellent safety in preclinical studies. It is currently being assessed in a Phase I clinical trial in preparation for evaluation in patients with severe treatment-resistant depression. A second generation series of compounds is advancing rapidly in preclinical development.




    Contacts:
    Corpo
'/>"/>
SOURCE Naurex Inc.
Copyright©2009 PR Newswire.
All rights reserved

Page: 1 2 3

Related medicine technology :

1. Naurex Inc. Announces Presentation of Preclinical Data Showing its Novel Mechanism NMDA Modulator Exhibits Robust and Rapid-Onset Antidepressant Activity With No Signs of Classic NMDA-Associated Side Effects
2. Keryx Biopharmaceuticals, Inc. Initiates Phase 3 Registration Trial of KRX-0401 (Perifosine) for Treatment of Patients with Advanced Multiple Myeloma
3. ChemoCentryx Initiates Phase 2 Clinical Trial of CCX354 for the Treatment of Rheumatoid Arthritis
4. Sangart, Inc. Initiates Phase IIa Study of Oxygen Therapeutic Agent MP4OX in Severe Trauma Patients With Hemorrhagic Shock
5. Bayer HealthCare Pharmaceuticals Initiates Phase III Trial with Florbetaben PET Tracer for Imaging of Cerebral beta-Amyloid Plaques, a Pathological Hallmark of Alzheimers Disease
6. Proteon Initiates Second Phase 1/2 Clinical Study of PRT-201 in Hemodialysis Patients
7. Echo Therapeutics Initiates Clinical Study of its New One-Piece Symphony(TM) tCGM Biosensor in Type 1 and Type 2 Diabetic Patients
8. Incept BioSystems Initiates First Human Clinical Trial of its SMART Embryo Culture System for In Vitro Fertilization (IVF)
9. BioMarin Initiates Phase 2 Clinical Study of PEG-PAL in PKU
10. Lexicon Completes Phase 1 Clinical Trial and Initiates Phase 2 Clinical Trial of LX4211 in Patients With Type 2 Diabetes
11. LigoCyte Pharmaceuticals Initiates a Randomized, Double Blind, Placebo Controlled Norovirus Vaccine Study Including Live Virus Challenge
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/4/2015)... , May 4, 2015  Verus Healthcare, Inc. ... acquisition of CPAP Care Club in 2012.  Since that ... within the durable medical equipment (DME) industry by 1,000%.  ... for their CPAP supply needs and processes nearly 14,000 ... this company three years ago, the systems and processes ...
(Date:5/4/2015)... , May 4, 2015 ... Market by Scope (Rigid (Laparoscope, Ureteroscope), Flexible (Colonoscope, Gastroscope), ... by Application (Colonoscopy, Laparoscopy, Arthroscopy) - Global Forecasts to ... expected to reach $19.0 Billion by 2019 with a ... to 2019). Browse   127   ...
(Date:5/4/2015)... 2015 /PRNewswire/ - YOLO Medical Inc. , ... distribution of medical and aesthetic devices, proudly announces ... YOLO,s new generation body contouring laser system; LIPOFINA. ... second-generation low-level laser device for body contouring, creating ... patented technology while continuing to push the envelope ...
Breaking Medicine Technology:Verus Healthcare Celebrates 1,000% Growth on Third Anniversary 2The Medical Videoscope Market Worth $19.0 Billion by 2019 2The Medical Videoscope Market Worth $19.0 Billion by 2019 3The Medical Videoscope Market Worth $19.0 Billion by 2019 4The Medical Videoscope Market Worth $19.0 Billion by 2019 5YOLO Medical Inc. receives FDA clearance for body contouring laser 2
... 2011 Reportlinker.com announces that a new ... its catalogue: Immunotherapy ... http://www.reportlinker.com/p0284906/Immunotherapy-in-Oncology-Drug-Pipeline-Update-2011.html#utm_source=prnewswire&utm_medium=pr&utm_campaign=Biological_Therapy ... attractive therapeutic addition, delivering treatment of ...
... Scotland, September 7, 2011 The Astellas European ... Transplantation Grant: Dr Christian Toso of the University ... led by Dr Toso, received the grant of US$ 300,000 ... tailored immuno - suppression after liver transplantation for ...
Cached Medicine Technology:Immunotherapy in Oncology Drug Pipeline Update 2011 2Immunotherapy in Oncology Drug Pipeline Update 2011 3Immunotherapy in Oncology Drug Pipeline Update 2011 4Immunotherapy in Oncology Drug Pipeline Update 2011 5Immunotherapy in Oncology Drug Pipeline Update 2011 6Immunotherapy in Oncology Drug Pipeline Update 2011 7The Astellas European Foundation Winner of Transplantation Grant 2011 Announced 2
(Date:5/4/2015)... 2015 New findings released today from ... (ABTA) show that people diagnosed with a brain tumor ... including clinical trials, at the time of diagnosis, and ... decisions about their course of treatment. The release of ... nationwide brain tumor volunteer network, the ABTA CommYOUnity™, dedicated ...
(Date:5/4/2015)... 2015 Dr. Benjamin Stong of Kalos ... the latest non-surgical double-chin eliminator. Dr. Stong is ... in Atlanta to offer Kybella treatments . The ... specifically under the chin, promising to safely dissolve fat ... patients who sought immediate solutions for their double chin ...
(Date:5/4/2015)... May 04, 2015 In response ... Preventive Services Task Force (USPSTF), Strategic Radiology® (SR®) ... Congress of Obstetricians and Gynecologists (ACOG), the American ... Cure, American Cancer Society (ACS), American College of ... to unanimously recommend regular screening mammography for women ...
(Date:5/4/2015)... “ Food Cost Calculator ” was featured on NewsWatch ... at the latest and coolest applications on the market for ... and technology expert, conducted the app review and shared with ... efficiently calculate food costs. , The restaurant industry is a ... has an estimated 1.8 trillion dollar impact on the US ...
(Date:5/4/2015)... San Diego, CA (PRWEB) May 04, 2015 ... New Cireson Platform to ... Cireson offers customers a choice to consume Microsoft ... cloud or Hyper-V on premise , Company ... focused model , Continuous innovation with expanding ...
Breaking Medicine News(10 mins):Health News:American Brain Tumor Association Poll Underscores Need for Greater Awareness and Education at Time of Diagnosis 2Health News:American Brain Tumor Association Poll Underscores Need for Greater Awareness and Education at Time of Diagnosis 3Health News:Facial Plastic Surgeon First in Atlanta To Offer Kybella Treatments To Reduce Chin Fat 2Health News:Strategic Radiology® Takes Unified Stance Against New USPSTF Guidelines 2Health News:Strategic Radiology® Takes Unified Stance Against New USPSTF Guidelines 3Health News:Strategic Radiology® Takes Unified Stance Against New USPSTF Guidelines 4Health News:Strategic Radiology® Takes Unified Stance Against New USPSTF Guidelines 5Health News:An Application to Manage a Successful Restaurant Was Featured on NewsWatch Television 2Health News:Cireson Unveils New Microsoft Cloud & System Center Strategy 2Health News:Cireson Unveils New Microsoft Cloud & System Center Strategy 3Health News:Cireson Unveils New Microsoft Cloud & System Center Strategy 4
... 4 Crdentia Corp. (OTC Bulletin,Board: CRDT), ... services,today announced the appointment of Mr. Randall ... Chief Clinical Officer. In this newly created,position, ... compliance and accreditation, assisting in business,plan development ...
... Online Resource to Support Journal Editors Handling ... of scientific, technical and,medical information products and ... Ethics Resource Kit (PERK),( http://www.elsevier.com/publishingethicskit )., ... in Singapore, Mark,Seeley, Senior Vice President and ...
... 4 Seniors have done their share.,Millions stepped ... insurance and state government have failed to stop,runaway ... rich coverage have,been forced to lapse their policies. ... approval and endorsement., Last week,s Wall Street ...
... nutrient education, WHITE PLAINS, N.Y., March 4 Despite ... to take drastic measures to lose,weight, with one third saying ... lose a few pounds, a recent survey found., Although ... of the time or more often, many do not fully ...
... report they are not getting the sleep they need ... may contribute to their inadequate sleep. The survey, issued ... (ACCP-SI), found that most physicians sleep fewer hours than ... believe their work schedules do not allow for adequate ...
... cellular pathways involved in cancer metastasis , , MONDAY, March ... regulates development of human embryonic stem cells can inhibit ... breast cancers, says a study by researchers at Northwestern ... week,s online issue of the Proceedings of the ...
Cached Medicine News:Health News:Crdentia Appoints Randall Turnbull to Senior Vice President and Chief Clinical Officer 2Health News:Crdentia Appoints Randall Turnbull to Senior Vice President and Chief Clinical Officer 3Health News:Elsevier Launches Publishing Ethics Resource Kit 2Health News:State Governments are Snookering Seniors 2Health News:New Survey Shows 90 Percent of Women Do Not Fully Understand the Calories They Eat 2Health News:New Survey Shows 90 Percent of Women Do Not Fully Understand the Calories They Eat 3Health News:Physicians report they need more sleep 2Health News:Physicians report they need more sleep 3Health News:Embryonic Stem Cell Protein Inhibits Melanoma 2
... Flexible Ureteroscope (DUR-D) incorporates many of ... durable, market leading DUR® series flexible ... device utilizing Gyrus ACMIs proprietary, worlds ... Oxide Semi-Conductor (CMOS) distal sensor technology ...
... new ImmunoCard STAT! EHEC is the first one-step ... Shiga Toxin 1 and 2 produced by Enterohemorrhagic ... on McConkey broth overnight enrichment of fecal specimens ... and 100% specificity., The separate result for Toxin ...
Inquire...
... elegant and sophisticated woman, the ... ophthalmic and sunwear styles. Frames ... of shapes and colors, designed ... and complexions. Many styles feature ...
Medicine Products: