Navigation Links
Nature Article Implicates microRNAs in the Pathogenesis of Obesity and Type 2 Diabetes
Date:6/8/2011

hat antagonizing miR-103/107 with therapeutic anti-miR oligonucleotides can regulate insulin sensitivity in mouse models of obesity and diabetes," said Neil W. Gibson, Ph.D., chief scientific officer at Regulus. "This new paper, and others we have published recently on miR-33, supports the development of anti-miRs as potential therapeutics for metabolic diseases. This is one of the many exciting exploratory opportunities we are evaluating."

Prof. Markus Stoffel with the Institute for Molecular Systems Biology, ETH Zurich, and member of Regulus' scientific advisory board, said: "Our studies with Regulus and Alnylam show the importance of miR-103/107 to insulin sensitivity. The data establish miR-103/107 as a potential therapeutic target for the treatment of type 2 diabetes and obesity."

About microRNAs

The discovery of microRNA in humans during the last decade is one of the most exciting scientific breakthroughs in recent history. microRNAs are small RNA molecules, typically 20 to 25 nucleotides in length, that do not encode proteins but instead regulate gene expression. More than 700 microRNAs have been identified in the human genome, and over one-third of all human genes are believed to be regulated by microRNAs. A single microRNA can regulate entire networks of genes. As such, these molecules are considered master regulators of the human genome. microRNAs have been shown to play an integral role in numerous biological processes, including the immune response, cell-cycle control, metabolism, viral replication, stem cell differentiation and human development. Most microRNAs are conserved across multiple species, indicating the evolutionary importance of these molecules as modulators of critical biological pathways. Indeed, microRNA expression, or function, has been shown to be significantly altered in many disease states, including cancer, heart failure and viral infections. Targe
'/>"/>

SOURCE Regulus Therapeutics Inc.
Copyright©2010 PR Newswire.
All rights reserved

Page: 1 2 3 4 5 6 7

Related medicine technology :

1. Sangamo BioSciences and Sigma-Aldrich Announce Nature Biotechnology Study Demonstrating Zinc Finger Technology for Modification of Human Stem Cells
2. Brain Signature for Cigarette Cravings Identified
3. Oncology Drug Development Update - Molecular Profiling Redefines the Nature of Malignancy and Increases the Adoption of Targeted Therapeutics
4. Sangamo BioSciences Announces Nature Biotechnology Study Demonstrating the Use of Zinc Finger Nucleases to Generate HIV Resistant T Cells
5. Nature Publication Reports on Key Role of Bile Acids in Glucose Metabolism and Insulin Signaling
6. InVitrias Cellastim Showcased in Nature Article
7. InnoCentive and Nature Publishing Group Announce Partnership to Facilitate Open Innovation
8. Siemens Corporate Research Develops RAPID2 System for Fast Discovery of Discriminative Pathogen Signatures
9. Genomic Health Study Shows Breast Cancers in Men Display Very Similar Gene Signatures to Those in Women
10. Groundbreaking Study Published in Nature Biotechnology Demonstrates Sensitivity of Single Molecule Test for Detection of Prostate Cancer
11. Sangamo BioSciences Announces Nature Biotechnology Study Demonstrating the Use of Zinc Finger Nucleases to Generate HIV Resistant Human Stem Cells
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/22/2014)... , Aug. 22, 2014  WaferGen Bio-systems, Inc. (NASDAQ: ... offering of units of common stock and warrants at ... of $20 million, prior to deducting underwriting discounts and ... shares and warrants are immediately separable and will be ... to begin trading on The NASDAQ Stock Market under ...
(Date:8/21/2014)... Hermann Health System and The University of Texas ... to provide a new level of specialized breast screening at ... Houston area. Starting in ... professional breast radiology services for five of Memorial Hermann,s 10 ... Woodlands , Northeast, Southwest and Sugar Land ...
(Date:8/21/2014)... Nektar Therapeutics (NASDAQ: NKTR ... results from its Phase 3 pivotal clinical trial ... factor VIII (rFVIII) treatment for hemophilia A based ... primary endpoint in reducing annualized bleed rates (ABR) ... arm. Top-line results from the prospective, ...
Breaking Medicine Technology:WaferGen Bio-Systems Announces Pricing of $20 Million Underwritten Offering and Uplisting to NASDAQ 2WaferGen Bio-Systems Announces Pricing of $20 Million Underwritten Offering and Uplisting to NASDAQ 3WaferGen Bio-Systems Announces Pricing of $20 Million Underwritten Offering and Uplisting to NASDAQ 4Memorial Hermann, MD Anderson join forces to provide enhanced breast imaging services throughout the Greater Houston Region 2Memorial Hermann, MD Anderson join forces to provide enhanced breast imaging services throughout the Greater Houston Region 3Memorial Hermann, MD Anderson join forces to provide enhanced breast imaging services throughout the Greater Houston Region 4Baxter Announces Positive Top-Line Results from Its Phase 3 Study of BAX 855, Extended Half-Life Recombinant FVIII for Hemophilia A Patients 2Baxter Announces Positive Top-Line Results from Its Phase 3 Study of BAX 855, Extended Half-Life Recombinant FVIII for Hemophilia A Patients 3Baxter Announces Positive Top-Line Results from Its Phase 3 Study of BAX 855, Extended Half-Life Recombinant FVIII for Hemophilia A Patients 4Baxter Announces Positive Top-Line Results from Its Phase 3 Study of BAX 855, Extended Half-Life Recombinant FVIII for Hemophilia A Patients 5
(Date:8/23/2014)... 2014 Dealing with a drug or alcohol ... the addict is a child. Adolescent addiction has been an ... time, but a new helpline is now providing a valuable ... to find a real addiction recovery center. , The Troubled ... impact in the community. By calling (404) 975-2762, parents and ...
(Date:8/23/2014)... 2014 Teen drug and alcohol abuse ... different in Wilmington, NC. Substance abuse can happen to ... to drug and alcohol dependency in higher numbers than ... overcome substance abuse, but don’t know where to find ... can be a challenge because most treatment options are ...
(Date:8/23/2014)... Summer vacation is almost over and before we know ... shopping for school supplies and a new wardrobe might take ... students to also spend some time brushing up on bed ... thrive in heavily populated places,” said Randy Rupert, Bed Bug ... perfect settings for bed bugs to take up residence.” , ...
(Date:8/22/2014)... The IT manager of Top10BestSEOHosting.com is a ... years. He has recently announced that GoDaddy ( http://www.top10bestseohosting.com/go/GoDaddy.com/ ... 2014. , GoDaddy is a popular supplier of cheap ... hosting solutions at affordable rates. It offers three Linux ... plans depend on the length of the contract. The ...
(Date:8/22/2014)... On Friday, Aug. 22, Liberty University ... Sciences , hosting a ceremony in its courtyard attended ... and public welfare. , The 162-member inaugural class of ... (LUCOM) joined Liberty staff, faculty, and community leaders in ... new medical school. Classes began on Monday, Aug. 4. ...
Breaking Medicine News(10 mins):Health News:Atlanta’s New Troubled Teen Helpline Is Making a Difference in the Community 2Health News:Troubled Teens Wilmington Helpline Guides Adolescents to the Path of Recovery 2Health News:Expert Advice for a Bed Bug-Free School Year 2Health News:Liberty University Dedicates Its New Center for Medical and Health Sciences 2Health News:Liberty University Dedicates Its New Center for Medical and Health Sciences 3Health News:Liberty University Dedicates Its New Center for Medical and Health Sciences 4
... it still hasn,t been determined whether one disorder causes ... (HealthDay News) -- Alcohol abuse may increase the risk ... New Zealand study suggests. , Previous research has identified ... depression. But it hasn,t been determined whether one disorder ...
... Calif., March 6 Huntington Hospital Cancer Center ... the American College of Surgeons Commission on Cancer ... excellence in providing quality care to their patients."This ... commitment by Huntington,s medical staff, hospital staff and ...
... knees less effective in deep joint areas, study finds ... injection of hyaluronic acid is no more effective than a ... finds. , Hyaluronic acid (HA), a substance found in normal ... fluid, which lubricates and protects joints. The use of HA ...
... 6 /PRNewswire-Asia-FirstCall/ -- China Yingxia,International, Inc. (OTC ... a leading provider in the nutraceutical industry ... nutritional food products,dietary supplements and personal care ... today disclosed that its CEO and chairwoman, ...
... chest wall to decrease volume, study says , , FRIDAY, ... middle can put the squeeze on your lungs, according ... , It was already known that abdominal obesity (waist ... than 40 inches for men) was associated with diabetes, ...
... 6 The Penta Water Company ( http://pentawater.com ), ... water, is taking the bold step of turning to ... for their new packaging.In collaboration with Earth First Packaging ... the bottle water industry to convert its plastic-based BOPP ...
Cached Medicine News:Health News:Drinking May Trigger Genetic Marker for Depression 2Health News:Huntington Hospital Cancer Center Receives Outstanding Achievement Designation 2Health News:Hip Osteoarthritis Therapy No Better Than Placebo 2Health News:China Yingxia International, Inc.'s chairwoman and CEO is in talks with investors in China 2Health News:China Yingxia International, Inc.'s chairwoman and CEO is in talks with investors in China 3Health News:Belly Fat Puts the Pressure on Lungs 2Health News:Back to Basics: Penta Water Pairs Its Ultra-Pure Water With Packaging Made of Rock 2
Autolensmeter with color 5.7 inch LCD screen and built in printer....
... CF-60UVi is a diversified wide-angle ... FAG, ICG (optional) with various ... in the market), 40 degrees ... one picture and 30 degrees ...
... to eliminate the subjective nature of manual ... repeatable, objective measurements every time. The easy ... operating system ensure fast and simple operation. ... lens positioning and, in auto mode, users ...
An ideal basic fundus fluorescein camera with quality enhancing features at a mid-range price point. The camera has 1.7x magnification at 60 degree and 2.5x at 40 degree....
Medicine Products: