Navigation Links
Nature Article Implicates microRNAs in the Pathogenesis of Obesity and Type 2 Diabetes
Date:6/8/2011

LA JOLLA, Calif., and CAMBRIDGE, Mass., June 8, 2011 /PRNewswire/ -- Regulus Therapeutics Inc., a biopharmaceutical company leading the discovery and development of innovative medicines targeting microRNAs, and Alnylam Pharmaceuticals, Inc. (Nasdaq: ALNY), a leading RNAi therapeutics company, today announced the publication in Nature of new pre-clinical data in mice about the antagonism of microRNA-103 and microRNA-107 (miR-103/107). Data from a collaborative study performed by Regulus, Alnylam and ETH Zurich demonstrated that antagonism of miR-103/107 with proprietary chemically modified anti-miR oligonucleotides could promote insulin signaling in both liver and adipose tissue.  Silencing miR-103/107 in animal models of obesity improved glucose homeostasis, suggesting that these microRNAs are potential targets for the treatment of diabetes.  

Defects in insulin signaling are among the most common and earliest defects that predispose an individual to the development of type 2 diabetes. The new findings demonstrated that miR-103/107 are upregulated in obese mice, and silencing with anti-miRs could improve glucose homeostasis and insulin sensitivity, while gain of function in liver or fat caused impaired glucose homeostasis. Direct targets of miR-103/107 identified include caveolin-1, a critical regulator of the insulin receptor.  Upon miR-103/107 inactivation, caveolin-1 is upregulated, resulting in stabilization of the insulin receptor, enhanced insulin signaling, decreased adipocyte size and enhanced insulin-stimulated glucose uptake.

"microRNAs are a new class of regulatory molecules that influence many biological functions, including metabolism. These studies suggest t
'/>"/>

SOURCE Regulus Therapeutics Inc.
Copyright©2010 PR Newswire.
All rights reserved

Page: 1 2 3 4 5 6 7

Related medicine technology :

1. Sangamo BioSciences and Sigma-Aldrich Announce Nature Biotechnology Study Demonstrating Zinc Finger Technology for Modification of Human Stem Cells
2. Brain Signature for Cigarette Cravings Identified
3. Oncology Drug Development Update - Molecular Profiling Redefines the Nature of Malignancy and Increases the Adoption of Targeted Therapeutics
4. Sangamo BioSciences Announces Nature Biotechnology Study Demonstrating the Use of Zinc Finger Nucleases to Generate HIV Resistant T Cells
5. Nature Publication Reports on Key Role of Bile Acids in Glucose Metabolism and Insulin Signaling
6. InVitrias Cellastim Showcased in Nature Article
7. InnoCentive and Nature Publishing Group Announce Partnership to Facilitate Open Innovation
8. Siemens Corporate Research Develops RAPID2 System for Fast Discovery of Discriminative Pathogen Signatures
9. Genomic Health Study Shows Breast Cancers in Men Display Very Similar Gene Signatures to Those in Women
10. Groundbreaking Study Published in Nature Biotechnology Demonstrates Sensitivity of Single Molecule Test for Detection of Prostate Cancer
11. Sangamo BioSciences Announces Nature Biotechnology Study Demonstrating the Use of Zinc Finger Nucleases to Generate HIV Resistant Human Stem Cells
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/15/2014)... Dec. 15, 2014 As medical device manufacturers ... Labeling) markup language standard, content teams have a greater ... to work with the standard. Starting January 2015, Data ... webinars on the benefits and the critical aspects of ... be facilitated by Howard Shatz , DCL,s SPL ...
(Date:12/14/2014)... Dec. 14, 2014  ChartSpan, a consumer platform for ... iPhone and iPad medical app in the ... http://photos.prnewswire.com/prnh/20141214/164317 ChartSpan is an iPhone ... request, manage and send electronic healthcare records. The product ... grew tired of waiting for the healthcare system to ...
(Date:12/13/2014)... 12, 2014 Mindray Medical International Limited ("Mindray", ... and marketer of medical devices worldwide, today announced shareholder ... held in Hong Kong on ... shareholders voted to re-elect incumbent directors Li Xiting and ... shareholders did not re-elect Peter Wan as ...
Breaking Medicine Technology:Data Conversion Laboratory Helping Life Sciences Content Producers Understand the Impact and Benefits of Structured Product Labeling 2Data Conversion Laboratory Helping Life Sciences Content Producers Understand the Impact and Benefits of Structured Product Labeling 3ChartSpan Becomes The Most Downloaded Medical App in America 2ChartSpan Becomes The Most Downloaded Medical App in America 3Mindray Announced Shareholder Resolutions Post 2014 Annual General Meeting 2
... and Potentially Suited for Once,Daily Administration, PRINCETON, ... an innovator in the discovery and development ... results,from the initial Phase 1 clinical trial ... for the treatment of hypertension,and diabetic nephropathy. ...
... for potential combination,therapies and details of N3/4A ... April 11, 2007 /PRNewswire-FirstCall/ --,InterMune, Inc. announced ... vitro experiments concerning its HCV protease inhibitor,ITMN-191, ... at the 42nd,Annual Meeting of the European ...
Cached Medicine Technology:Pharmacopeia Announces Positive Results from Initial DARA Clinical,Trial 2Pharmacopeia Announces Positive Results from Initial DARA Clinical,Trial 3Pharmacopeia Announces Positive Results from Initial DARA Clinical,Trial 4Pharmacopeia Announces Positive Results from Initial DARA Clinical,Trial 5InterMune Presents Research on ITMN-191 in Hepatitis C at EASL,Annual Meeting 2InterMune Presents Research on ITMN-191 in Hepatitis C at EASL,Annual Meeting 3InterMune Presents Research on ITMN-191 in Hepatitis C at EASL,Annual Meeting 4
(Date:12/17/2014)... December 17, 2014 Dr. Myo Nwe is ... Loss Diet of the Future” and co-founder of the Ace ... book, Dr. Nwe takes a broad look at the industry ... up under scientific scrutiny. On film and in television shows, ... mostly toward the social aspects and played for basic laughs, ...
(Date:12/17/2014)... A group of 127 scientists sent an ... reaction to a recent statement by the center that was ... derogated the efficacy of all brain exercises. , Signatories to ... of the center’s statement critical of brain exercise companies that ... overstated its case, in a document it had entitled “A ...
(Date:12/17/2014)... Project Veritas is releasing a video ... MIT economist and Obamacare architect Jonathan Gruber to public ... the interview, which is being distributed on YouTube. , ... mislabeling in the Affordable Care Act in order to ... billion dollar per year tax grab. , “President Obama ...
(Date:12/17/2014)... (HealthDay News) -- Poor students get more fruits and vegetables ... finds. But, the opposite is true for students from ... vegetables at school may give a healthy boost to poor ... what the family income level, students all ate a similar ... The study was published recently in the journal ...
(Date:12/17/2014)... HealthDay Reporter , TUESDAY, Dec. 16, ... America, and work commitment is a big reason why, new ... said Dr. Mathias Basner, an assistant professor of sleep and ... of Medicine. A time-use survey of nearly 125,000 Americans, ... main activity exchanged for sleep. Short sleepers -- those who ...
Breaking Medicine News(10 mins):Health News:Obesity Should Not Be a Hollywood Punchline, Weight Loss Doc Says 2Health News:Scientists to Stanford: Research Shows Brain Exercises Can Work 2Health News:Scientists to Stanford: Research Shows Brain Exercises Can Work 3Health News:Scientists to Stanford: Research Shows Brain Exercises Can Work 4Health News:Project Veritas: James O’Keefe Interviews the Man Who Discovered Jonathan Gruber Videos 2Health News:Poor Students Eat Healthier Foods at School, Study Finds 2Health News:Work Steals Valuable Sleep Time, Study Finds 2Health News:Work Steals Valuable Sleep Time, Study Finds 3
... Not-for-Profit Company,s Desire to Serve Seniors and ... Markets, LONG BEACH, Calif., July 8 ... investment banking, has been appointed vice,president of mergers ... CEO David Schmidt announced today. With this appointment, ...
... ran,up against her state,s discriminatory child custody law when ... to battle to get her back. To help,parents who, ... and,deserve, to keep or regain custody of their children, ... initiative to,educate legislators around the country in order to ...
... President and CEO Blue Cross and Blue,Shield Association, ... executive officer of the Blue Cross and Blue Shield,Association, ... launch,of a new healthcare coalition, Health Care America Now:, ... strongly with the,Health Care America Now coalition that everyone ...
... Syrup containing sugar substitute xylitol actually helps prevent cavities, ... A new sweet treat that actually prevents children,s cavities ... The tasty syrup, which contains the sugar substitute xylitol, ... a role in protecting permanent teeth, says a ...
... Nashville, Tenn. July 7, 2008 A new article ... and possibly magnesium and calcium by dietary means may ... pressure in people with hypertension. A high intake of these ... coronary heart disease and stroke. These findings are published in ...
... play in preventing, recovering from ... health information theft, CHICAGO, ... theft of their medical identity and follow a,"checklist" of recovery steps ... new practice brief, "Mitigating Medical,Identity Theft," published in the July issue ...
Cached Medicine News:Health News:SCAN Health Plan Appoints Arthur Henkel Vice President of Mergers and Acquisitions 2Health News:Collaborative Launches Initiative to Protect Rights of Parents with Mental Illnesses 2Health News:Collaborative Launches Initiative to Protect Rights of Parents with Mental Illnesses 3Health News:Blue Cross and Blue Shield Association Statement: Health Care America Now 2Health News:A Sweet Way to Shield Baby's Teeth 2Health News:A Sweet Way to Shield Baby's Teeth 3Health News:Leading worldwide cause of cardiovascular disease may be modified by diet 2Health News:Mitigating Medical Identity Theft: AHIMA Journal Provides Patient Tools to Secure Health Information 2Health News:Mitigating Medical Identity Theft: AHIMA Journal Provides Patient Tools to Secure Health Information 3
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
Medicine Products: