Navigation Links
National Library of Medicine Awards Phase I SBIR Grant to Collaborative Drug Discovery, Inc. to Develop Computational Tools for Biocomputation across Distributed Private Datasets to Enhance Drug Discovery
Date:9/13/2011

BURLINGAME, Calif., Sept. 13, 2011 /PRNewswire/ -- Collaborative Drug Discovery (CDD), a provider of a web-based drug discovery software platform, announced they have been awarded a grant for a software development project focused on ADME/Tox and tuberculosis drug discovery data sharing.

The Phase I Small Business Innovation Research (SBIR) grant from the National Library of Medicine, part of the National Institutes of Health, is part of a program to enable sharing of biological data.

"Following our valuable collaboration with Pfizer, which resulted in the paper "Using Open Source Computational Tools for Predicting Human Metabolic Stability and Additional Absorption, Distribution, Metabolism, Excretion, and Toxicity Properties" (1) and several publications on tuberculosis computational models (2-6), we realized there was an opportunity to use CDD to host and selectively share computational models" said Sean Ekins, Ph.D., D.Sc., Collaborations Director, CDD. "Our collaborators at Pfizer have demonstrated that computational models generated for very large datasets with open cheminformatics tools were equivalent to those generated with commercial tools and thus provides a way to potentially share models in a platform agnostic manner".

"The grant will fund proof of concept work using Open source cheminformatics tools in collaboration with pharmaceutical and not for profit groups and will build on our pioneering work of secure selective sharing of data on the cloud," said Barry Bunin, president & CEO of CDD. "This project extends our work on TB and is complementary with our goal bringing groups together to collaborate and share their data when desirable.  The technology will extend the existing innovations selectively sharing data, to selectively sharing models, even without sharing or even uploading sensitive data." "It has the potential to remove barriers between precompetitive and competitive markets and this grant will enable us to further enhance how the cloud is used and develop a new product in the future".

The project described was supported by Award Number 1R43LM011152-01 from the National Library of Medicine. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Library of Medicine or the National Institutes of Health.

About Collaborative Drug Discovery, Inc.CDD (www.collaborativedrug.com) provides the most widely used web-based drug discovery software platform on the market. "CDD Vault™" is the secure, private industrial-strength database combining traditional drug discovery informatics (registration and SAR) with social networking capabilities. "CDD Collaborate™" enables real-time collaboration by securely exchanging selected confidential data with external researchers. "CDD Public™" enables researchers to mine a unique aggregation of information from a variety of scientific data providers.References(1)

Rishi R. Gupta, Gifford, EM, Liston T, Waller CL, Hohman M, Bunin BA and Ekins S, Using open source computational tools for predicting human metabolic stability and additional ADME/Tox properties, Drug Metab Dispos, 38: 2083-2090, 2010.(2)

Ekins S and Freundlich JS, Validating new tuberculosis computational models with public whole cell screening aerobic activity datasets, Pharm Res, 28, 1859-1869, 2011.(3)

Lamichhane G, Freundlich JS, Ekins S , Wickramaratne N, Nolan, S and Bishai WR, Essential Metabolites of M. tuberculosis and their small molecule mimics, Mbio, 2: e00301-10, 2011.(4)

Ekins S, Freundlich JS, Choi I, Sarker M and Talcott C, Computational Databases, Pathway and Cheminformatics Tools for Tuberculosis Drug Discovery, Trends In Microbiology, 19: 65-74, 2011.(5)

Ekins S, Kaneko T, Lipinski CA, Bradford J, Dole K, Spektor A, Gregory K, Blondeau D, Ernst S, Yang J, Goncharoff N, Hohman M and Bunin BA, Analysis and hit filtering of a very large library of compounds screened against Mycobacterium tuberculosis, Mol Biosyst, 6: 2316-2324, 2010.(6)

Ekins S, Bradford J, Dole K, Spektor A, Gregory K, Blondeau D, Hohman M  and Bunin BA, A Collaborative Database and Computational Models for Tuberculosis Drug Discovery, Mol BioSyst, 6: 840-851, 2010.
'/>"/>

SOURCE Collaborative Drug Discovery, Inc.
Copyright©2010 PR Newswire.
All rights reserved

Related medicine technology :

1. Vicus Therapeutics to Present at the 234th American Chemical Society National Meeting in Boston, MA
2. National Stem Cell Holding, Inc. Discovers Non-Embryonic Biomaterials that Promote Tissue Repair
3. Intellect Neurosciences, Inc. to Present Data on Alzheimers Vaccine at 13th International Congress of Immunology Conference
4. Paper in International Journal of Oncology Reports Alfacells ONCONASE(R) Suppresses Intracellular Oxidative Stress
5. Ozarelix Phase 2 Data Presented at 29th Congress of the Societe Internationale dUrologie
6. Anadys Pharmaceuticals Presents Preclinical Results on ANA598, a Non-Nucleoside Inhibitor of the NS5B Polymerase, at the 14th International Symposium on Hepatitis C Virus and Related Viruses
7. Public Forum to Discuss Addiction as a Treatable Disease and Highlight National Alcohol and Drug Addiction Recovery Month
8. K-State Researchers Bringing Expertise to Kansas City Symposium on Disease and National Security
9. International Expert Group Initiates Largest Multi-center Phase III Trial to Evaluate NeuroAid(TM) in Stroke Recovery
10. September is National Pain Awareness Month
11. Virogenomics, Inc. Awarded $2 Million National Institute of Standards and Technology (NIST) Advanced Technology Program Grant to Develop Integrated Diagnostic Biosensors
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/26/2016)... June 26, 2016 Story ... operating models within the health care industry is causing ... efficiency , Deloitte offers a suite of solutions ... issues impacting efficient cost optimization: labor resource analysis, revenue ... services facilitate better outcomes and better economics ...
(Date:6/24/2016)... 2016 Dublin ... addition of the " Global Markets for Spectroscopy ... This report focuses on the ... review, including its applications in various applications. The report ... includes three main industries: pharmaceutical and biotechnology, food and ...
(Date:6/24/2016)... Research and Markets has announced the addition of ... report to their offering. ... The World Market for Companion Diagnostics covers the world market ... the report includes the following: , World ... Region (N. America, EU, ROW), 2015-2020 , World IVD ...
Breaking Medicine Technology:
(Date:6/27/2016)... (PRWEB) , ... June 27, 2016 , ... ... for mental health professionals, announced today its affiliation with Tennessee Counseling Association. ... solutions to the network of the Tennessee Counseling Association, adding exclusive benefits and ...
(Date:6/26/2016)... ... June 27, 2016 , ... Quality metrics are proliferating ... many ways they remain in the eye of the beholder, according to experts who ... of The American Journal of Managed Care. For the full issue, click here ...
(Date:6/26/2016)... ... 26, 2016 , ... Brent Kasmer, a legally blind and certified personal trainer is helping to ... app. The fitness app plans to fix the two major problems leading the fitness industry ... fits all type program , They don’t eliminate all the reasons people quit ...
(Date:6/25/2016)... ... 2016 , ... The temporary closing of Bruton Memorial Library on June 21 due to a ... new, often overlooked aspect of head lice: the parasite’s ability to live away from a ... occurrence, but a necessary one in the event that lice have simply gotten out of ...
(Date:6/25/2016)... ... June 25, 2016 , ... Dr. Calvin Johnson has dedicated ... has implemented orthobiologic procedures as a method for treating his patients. The procedure ... doctors to perform the treatment. Orthobiologics are substances that orthopaedic surgeons use to ...
Breaking Medicine News(10 mins):