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National Jewish Health, the Nation's Premier Respiratory Hospital, Announces Lung Cancer Screening Trial Using Blood Test and CT
Date:5/1/2012

the time is now right to explore extending the use of the test to population screening for high risk patients," said Jett.

The National Jewish Health study complements the recently announced Scotland (UK) study of 10,000 high risk smokers which will determine the cost-effectiveness of using EarlyCDT-Lung as a primary screening tool. In the Scotland study, patients with a positive blood test result will have a follow up CT.

Jett was part of one of the first studies in the U.S. that looked at CT screening when he was at the Mayo Clinic. The study ran from 1999 to 2004 on approximately 1,600 patients. At that time CT seemed to have the potential to detect early lung cancer, and many clinicians believed it would lead to a mortality benefit. The Mayo study showed that use of CT did lead to earlier cancers being detected. Mortality benefit has subsequently been shown to be a reality with the announcement of the large National Cancer Institute's NLST on more than 53,000 participants. Those results showed a 20% mortality benefit with CT screening when compared to standard chest X-ray. The next stage in the development of screening for lung cancer is to investigate what other tests in conjunction with CT can add to the clinical utility of CT alone. A simple biomarker test that would allow better identification and risk assessment of "at risk" patients is attractive as it has the potential to increase the number of early stage cancers diagnosed and improve cost-effectiveness of screening.

"The lung cancer community is constantly monitoring potential bio-markers in development and the few that have come to market. The EarlyCDT-Lung test has now been on the market for over two years and its performance may translate to the benefits I have described and it is for this reason that I am delighted to be able to conduct this study. The study will screen 1,600 patients over 4 years and the first results are expected to be reported in 2014,"
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