Navigation Links
National Cancer Institute Research Identifies Unique Mechanism of Brostallicin's Anti-Tumor Effectiveness
Date:7/20/2009

SEATTLE, July 21 /PRNewswire-FirstCall/ -- Cell Therapeutics (CTI) (Nasdaq and MTA: CTIC) announced today that researchers from the Laboratory of Molecular Pharmacology at the National Cancer Institute presented new preclinical research identifying unique anti-tumor mechanisms of brostallicin that sets this agent apart from other currently used chemotherapy agents. CTI acquired worldwide rights to brostallicin when it acquired privately-held Systems Medicine LLC in 2007. Published in the journal Molecular Cancer Therapy (Mol Cancer Ther 2009;8(7) July 2009; 1985-94), the researchers utilized preclinical studies to provide clues into tumor susceptibility mechanisms for brostallicin, a synthetic DNA minor grove binder, and to identify differences between brostallicin and trabectedin (Yondelis(R); ET-743), which is a natural marine product approved in Europe. Unlike other chemotherapy agents, including trabectedin, the NCI research indicates that the tumor cell DNA damaging effects of brostallicin are enhanced by high tumor glutathione levels, a hallmark of drug-resistant tumors. Brostallicin was shown to affect DNA in both dividing and quiescent cells. Its actions can be followed by induction of a specific DNA binding protein foci that can be detected in circulating blood cells. Importantly, brostallicin was active in a trabectedin-resistant cell line.

"These preclinical data provide important further insights into the specific bio-marker (tumor glutathione levels) that increases the probability of achieving improved anti-tumor effectiveness by careful selection of patients who are most likely to benefit, and is consistent with our focus on personalized approaches to cancer drug development," said Jack Singer, M.D., Chief Medical Officer at CTI. "This may be of particular importance in patients with relapsed 'triple-negative' breast cancer, ovarian, or colorectal cancer following treatment with platinum
'/>"/>

SOURCE Cell Therapeutics, Inc.
Copyright©2009 PR Newswire.
All rights reserved

Page: 1 2 3 4

Related medicine technology :

1. Vicus Therapeutics to Present at the 234th American Chemical Society National Meeting in Boston, MA
2. National Stem Cell Holding, Inc. Discovers Non-Embryonic Biomaterials that Promote Tissue Repair
3. Intellect Neurosciences, Inc. to Present Data on Alzheimers Vaccine at 13th International Congress of Immunology Conference
4. Paper in International Journal of Oncology Reports Alfacells ONCONASE(R) Suppresses Intracellular Oxidative Stress
5. Ozarelix Phase 2 Data Presented at 29th Congress of the Societe Internationale dUrologie
6. Anadys Pharmaceuticals Presents Preclinical Results on ANA598, a Non-Nucleoside Inhibitor of the NS5B Polymerase, at the 14th International Symposium on Hepatitis C Virus and Related Viruses
7. Public Forum to Discuss Addiction as a Treatable Disease and Highlight National Alcohol and Drug Addiction Recovery Month
8. K-State Researchers Bringing Expertise to Kansas City Symposium on Disease and National Security
9. International Expert Group Initiates Largest Multi-center Phase III Trial to Evaluate NeuroAid(TM) in Stroke Recovery
10. September is National Pain Awareness Month
11. Virogenomics, Inc. Awarded $2 Million National Institute of Standards and Technology (NIST) Advanced Technology Program Grant to Develop Integrated Diagnostic Biosensors
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/26/2015)... Feb. 26, 2015  Mail-service and specialty pharmacies ... employers and government health plans $23.3 billion over ... the Pharmaceutical Care Management Association (PCMA). ... one of the easiest ways to reduce health ... Merritt . "Policymakers should resist efforts to restrict ...
(Date:2/26/2015)... Feb. 26, 2015 Every year many millions ... fight heart disease.  Nevertheless, year after year doctors and ... as the first test to determine the status of ... pain or not, even though that technology is over ... fact that doctors know, (while most patients do not ...
(Date:2/26/2015)... DUBLIN , Feb. 26, 2015 Research and ... addition of the "Radiation Therapy Equipment - Global ... This report analyzes the worldwide markets for ... Product Segments: Linear Accelerator, Treatment Planning Systems, and Radiation ... the US, Canada , ...
Breaking Medicine Technology:PCMA: Report Shows High-Tech Specialty and Mail-Service Pharmacies Will Reduce Costs for Texas Employers, Consumers and Public Programs by $23.3 Billion 2National Heart Health Month In February 2Radiation Therapy Equipment - Global Strategic Business Report 2015-2020: Linear Accelerator, Treatment Planning Systems, and Radiation Therapy Simulator 2
... 2011 Reportlinker.com announces that a new market research report ... Products http://www.reportlinker.com/p060973/Cosmetic-Surgery-Products.html ... Demand for products used in cosmetic surgery is forecast ... 2014, when 16.1 million cosmetic procedures are expected to be ...
... 2011 Medco Health Solutions, Inc. (NYSE: MHS ... to present at the following healthcare conferences: (Logo: ... CEOs Unscripted conference taking place in New York at the ... 8:45 a.m. ET; The 29th Annual JPMorgan ...
Cached Medicine Technology:Reportlinker Adds Cosmetic Surgery Products 2Reportlinker Adds Cosmetic Surgery Products 3Medco CEO to Present at Upcoming Healthcare Conferences 2
(Date:2/27/2015)... Sunnyvale, CA (PRWEB) February 27, 2015 ... showcase ClinCapture, its validated Electronic Data Capture (EDC) at ... Francisco, California on March 2nd and March 3rd at ... a self-service platform and DIY CRF and edit-check builder ... Checks in a matter of days, without any programming ...
(Date:2/27/2015)... 2015 Altec Products, Inc., announced today ... ERP Document Management Partner of the Year. ADSS Global ... and other complimentary solutions for their customers across the ... many years to provide clients with paperless solutions that ... “We are thrilled to recognize ADSS Global for their ...
(Date:2/27/2015)... In honor of American Heart Month in February, ... office, is offering tips on how to improve heart health. , ... doesn't mean people have to accept it as their fate. Although ... such as family history, sex or age — there are some ... has six helpful tips to improve heart health and prevent heart ...
(Date:2/27/2015)... 2015 Undocumented farmworkers are half ... use Medicaid, the federal health insurance program available ... new study from UC Davis Health System. The ... farmworker use of Medicaid, which provides coverage for ... status, was having children. , “Undocumented agricultural ...
(Date:2/27/2015)... (PRWEB) February 27, 2015 The federal ... ) that allege use of the statin medication can ... has issued a new order pertaining discovery in the ... Bernstein Liebhard LLP comments. The Order, which was issued ... on February 25th, directs the parties to schedule certain ...
Breaking Medicine News(10 mins):Health News:Clinovo to Demo Its Self-Service, Cloud-Based EDC Solution at CALBIO2015 on March 2nd and 3rd, 2015 2Health News:Altec Announces 2014 Sage ERP Document Management Partner of the Year Award Recipient 2Health News:Center for Primary Care Celebrates American Heart Month 2Health News:Center for Primary Care Celebrates American Heart Month 3Health News:Center for Primary Care Celebrates American Heart Month 4Health News:UC Davis Study Finds Undocumented Farmworkers Use Medicaid Half as Often as Documented Farmworkers 2Health News:UC Davis Study Finds Undocumented Farmworkers Use Medicaid Half as Often as Documented Farmworkers 3Health News:Federal Lipitor Litigation Issues New Order Pertaining to Discovery in Bellwether Cases, Bernstein Liebhard LLP Comments 2Health News:Federal Lipitor Litigation Issues New Order Pertaining to Discovery in Bellwether Cases, Bernstein Liebhard LLP Comments 3
... While the visual regions of the brain have been ... uncharted territory. Now, researchers at the Hebrew University of ... a key auditory process perceiving sound space, the ... concentrating on those sounds. , The findings settle ...
... MEDIA, Pa., Sept. 20 Synova Healthcare Group,Inc. (OTC ... sale,of approximately $3.3 million in aggregate notional principal amount ... September 19, 2012,and related common stock purchase warrants. This ... private placement of notes and warrants in the,aggregate notional ...
... Philadelphia, PA, September 20, 2007 Pedophilia, the sexual ... health concern and it does not respond well to ... not well understood. A new study being published ... the first of its kind to use functional brain ...
... Calif., Sept. 20 Cardiva Medical, Inc.,a privately ... Chairman and CEO, will present at the UBS ... in New York City. Notably, the,company will be ... the,Boomerang Catalyst II System, which recently received a ...
... 19, 2007 -- A single dose of Otsukas ... resulted in favorable changes in hemodynamics associated with ... with advanced heart failure (ADHF) who participated in ... HemodynamIc Parameters in Subjects with HEart failure (ECLIPSE), ...
... Speaker Nancy Pelosi,issued the following statement today on ... a vote of 405 to 7:, "Today,s sweeping, ... all Americans., "Essential to the safety net of ... that the prescription drugs they buy are safe. These ...
Cached Medicine News:Health News:Sensitivity of brain center for 'sound space' defined 2Health News:Synova Completes Sale of $3.3 Million in Senior Convertible Notes and Warrants 2Health News:Synova Completes Sale of $3.3 Million in Senior Convertible Notes and Warrants 3Health News:Pedophilia patients are found to have deficits in brain activation 2Health News:Cardiva Medical, Inc. to Present at the UBS 2007 Global Life Science Conference With the Announcement of FDA 510(K) Clearance of its Newest Device: The Boomerang Catalyst II System(TM) 2Health News:Cardiva Medical, Inc. to Present at the UBS 2007 Global Life Science Conference With the Announcement of FDA 510(K) Clearance of its Newest Device: The Boomerang Catalyst II System(TM) 3Health News:Cardiva Medical, Inc. to Present at the UBS 2007 Global Life Science Conference With the Announcement of FDA 510(K) Clearance of its Newest Device: The Boomerang Catalyst II System(TM) 4Health News:Cardiva Medical, Inc. to Present at the UBS 2007 Global Life Science Conference With the Announcement of FDA 510(K) Clearance of its Newest Device: The Boomerang Catalyst II System(TM) 5Health News:ECLIPSE data on effects of Otsuka's investigational novel treatment, Tolvaptan 2
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
Medicine Products: