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NanoBio Corporation Presents Preclinical and Interim Clinical Data on Topical Treatments for Herpes Labialis and Onychomycosis at AAD 2008
Date:2/1/2008

ing the epithelium or being systemically absorbed," Baker said. "The absence of systemic involvement could provide a significant advance for onychomycosis therapy in terms of safety." Current oral (systemic) drugs for onychomycosis pose risks of hepatic and cardiac toxicity, as well as the potential for drug interactions, Baker added.

In addition to its safety and tolerability, NB-002 activity was documented against numerous fungi involved in cutaneous infections, including Candida albicans, Microsporum canis, Epidermophyton floccosum, Trichophyton mentagrophytes and Trichophyton rubrum.

NanoBio is currently conducting a double-blind, placebo-controlled, phase 2 study to further investigate the efficacy and safety of NB-002 in 443 subjects with onychomycosis. All subjects have been enrolled, and the study is expected to be completed in February 2009.

The company's topical treatments are based on a novel anti-infective platform comprising an oil-in-water emulsion and a surfactant. The nanodroplets readily penetrate hair follicles and skin pores to reach the site of infection without disrupting skin or mucous membranes. Upon contact with the pathogen, the nanodroplets directly interact with the pathogen's outer membranes to lyse the virus, fungus or bacteria.

Poster Titles -- Link to posters at http://www.nanobio.com

-- Safety, Tolerance, Pharmacokinetics, and Efficacy of Topical

Nanoemulsion NB-001 for the Treatment of Herpes Labialis

-- Development of a Novel Antiviral Drug (NB-001) for Topical Application

in Humans

-- Safety, Tolerance, and Pharmacokinetics of Topical Nanoemulsion (NB-

002) for the Treatment of Onychomycosis

-- Development of a Novel Antifungal Drug (NB-002) for Topical Application

in Humans

About NanoBio

NanoBio(R) Corporation is a privately held biopharmaceutical company focused on develo
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SOURCE NanoBio Corporation
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