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NWBT Highlights Cost Effectiveness of DCVax® in View of Recent Immunotherapy Pricing Concerns
Date:8/10/2011

t a few weeks.

Another important factor in the cost effectiveness of DCVax® is its simplicity and ease of administration.  DCVax® is delivered as a small intra-dermal injection under the skin, similar to a flu shot.  As such, it can be administered in any physician's office or clinic.  There is no lengthy intravenous infusion, with the attendant patient discomfort, cost and need for a specialty infusion center.  In contrast, Dendreon's Provenge is delivered by intravenous infusion.

The cost effectiveness of NWBT's DCVax® is enhanced by the fact that DCVax® is targeting a portion of the prostate cancer market that is 4 times the size of the market segment that Dendreon's Provenge is currently targeting.  The late stage prostate cancer market breaks down into two groups of patients:  those who do not yet have metastases (i.e., spread of the cancer beyond the prostate), who constitute 80-85% of the market, and those who do already have metastases, who constitute 15-20% of the market.  Dendreon's Provenge is approved for and targeted to the patients with metastases (i.e., the 15-20% portion of the market).  In contrast, NWBT's prior Phase I/II trial treated both groups of patients, and NWBT's 612-patient Phase III trial design is focused on the much bigger market:  patients without metastases (i.e., 80-85% of the market).

About Northwest Biotherapeutics

Northwest Biotherapeutics is a biotechnology company focused on developing immunotherapy products to treat cancers more effectively than current treatments, without toxicities of the kind associated with chemotherapies, and on a cost-effective basis.  The Company has a broad platform technology for dendritic cell-based vaccines.  The Company's lead clinical trial, with a growing number of sites, is a 240-patient, Phase II trial in newly diagnosed Glioblastoma multiforme ("GBM"
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