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NWBT Highlights Cost Effectiveness of DCVax® in View of Recent Immunotherapy Pricing Concerns
Date:8/10/2011

ress and offer the potential for real cost-effectiveness, easier administration to patients, and longer extensions of patients' survival, as well as an absence of toxicity."

The pricing of DCVax® will also be substantially below the price range of most antibody drugs and "targeted" drugs for cancer. Such drugs are typically priced at $60,000-80,000 per year, and can exceed $100,000 per year.  Such drugs also carry significant side effects, and often only extend survival for as little as 10 weeks.

The key to the substantial pricing advantage of DCVax® is NWBT's proprietary batch manufacturing process together with its cryopreservation technology for frozen storage of the finished vaccine.  NWBT has spent a decade developing and improving its manufacturing and cryopreservation processes.  The manufacturing of personalized, living cell products is expensive.  But the frozen storage of living cells is quite low-cost – once the specialized freezing technology is worked out for a particular type of cells (the culture conditions, rate of freezing, density of cells and many other factors).  

NWBT's manufacturing methods produce – in a single manufacturing run – a large batch of personalized DCVax® product for 3 years of treatments that are much less costly than separate manufacturing runs for each treatment.  The technology for freezing the master immune cells (dendritic cells) which comprise DCVax® enables these cells to remain frozen for years and, when needed, to be thawed and "come back to life" with full potency.  

This approach makes DCVax®  an "off the shelf" product for several years of treatments after just one manufacturing run.  In contrast, Dendreon must do a separate manufacturing run for each one month of treatments.  In addition, Dendreon's Provenge product is fresh and not cryopreserved, which limits its shelf life to at mos
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SOURCE Northwest Biotherapeutics
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