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NW Bio Responds To Shareholder Inquiries Following Immune Therapy Sector's Recent Market Decline
Date:12/16/2013

BETHESDA, Md., Dec. 16, 2013 /PRNewswire/ -- Northwest Biotherapeutics, Inc. (NASDAQ: NWBO) ("NW Bio"), a biotechnology company developing non-toxic DCVax® personalized immune therapies for solid tumor cancers, today responded to inquiries from shareholders and investors about differences between NW Bio's technology, products and clinical trials and those of a Competitor who recently announced the results of a Phase II clinical trial with a dendritic cell vaccine for Glioblastoma multiforme (GBM).  NW Bio described several areas of significant differences.

(Logo: http://photos.prnewswire.com/prnh/20110329/SF73084LOGO)

Technology Differences.  A dendritic cell vaccine involves two main ingredients: the dendritic cells themselves (master cells of the immune system), and antigens (i.e., biomarker targets) associated with the particular cancer being treated.  The antigens are the targets on the cancer that the dendritic cell vaccine mobilizes the immune system to attack.  The antigen component of NW Bio's DCVax technology and products is different from the Competitor's in two ways which the Company believes are quite important.

  • First, NW Bio's DCVax uses the full set (potentially hundreds) of antigens on the patient's tumor.  In contrast, the Competitor uses only six pre-selected antigens -- and actually uses only fragments (peptides) of even these six antigens.  NW Bio believes that hitting the full set of antigens makes it harder for the tumor to "escape," and NW Bio has long emphasized this as a key difference between its DCVax technology and the Competitor's technology. 
  • Second, NW Bio's DCVax uses personalized antigens from the patient's ow
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SOURCE Northwest Biotherapeutics
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