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NW Bio Receives U.S. Patent On Broad Processes For Producing More Potent Dendritic Cells
Date:3/18/2013

y track the natural processes that occur in a healthy person's immune system.  NW Bio's methods avoid the premature activation of the precursors (monocytes), and develop pure immature dendritic cells -- avoiding the conflicting and confusing signals, and the need to override those signals with IL-4. 

Building upon the pure immature dendritic cells, NW Bio's patented methods develop mature and activated dendritic cells that are far more potent than dendritic cells produced in the standard way.  For example, NW Bio's dendritic cells produce as much as 10X or more the amount of signaling compounds which are key to mobilizing other active agents of the immune system, such as T cells (which infiltrate and attack tumors) and B cells (which produce antibodies).

NW Bio is already using these next generation methods for producing more potent dendritic cells in its production of DCVax-Direct.  The same patented methods for activating dendritic cells were also used in the pre-clinical animal studies with DCVax-Direct.  In those studies, injection of these potent dendritic cells into some of the tumors in each of the animals resulted in complete clearance of all tumors (both the tumors injected with DCVax-Direct and the tumors not injected) in 80-100% of the animals in the various studies, indicating a system-wide immune response. 

Going forward, NW Bio's now patented methods of producing more potent dendritic cells will also enable development of the next generation of NW Bio's other two product lines:  DCVax-L and DCVax-Prostate.  The current DCVax-L and DCVax-Prostate products have already delivered striking results in clinical trials to date, extending the time to tumor recurrence and the patients' survival time by 1-1/2 to 2 years or more, with a substantial portion of patients going far beyond that.  Incorporating NW Bio's patented methods for more potent dendritic cells will enable production
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SOURCE Northwest Biotherapeutics
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