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NW Bio Presenting At Phacilitate Cell Therapy Forum
Date:1/29/2013

cancers," commented Linda Powers , CEO of NW Bio.  "This multi-disciplinary gathering of scientific, medical, business and regulatory parties provides a unique forum for highlighting the multi-faceted strengths of our DCVax® products, including their scientific foundations, clinical significance, ease of administration and cost effectiveness." 

DCVax®-Direct is NW Bio's third product line.  It offers a potential new treatment option for a particularly severe unmet medical need:  the wide range of clinical situations in which patients' tumors are considered "inoperable" because the patient has multiple tumors, or their tumor cannot be completely removed, or the surgery would cause undue damage to the patient and impair their quality of life.  For these patients, the outlook today is bleak and survival remains quite limited.

When DCVax®-Direct was administered in pre-clinical animal studies, existing tumors regressed.  Importantly, the tumors that regressed included not only tumors that were injected with DCVax®-Direct but also tumors on the opposite side of the animal's body which were not injected, indicating a systemic immune response.  Further, when the animals were subsequently challenged (i.e., injected) with cancer cells, the animals did not re-develop cancer, indicating immune memory.  The Company's proprietary activation step for the dendritic cells was key to these striking results.

DCVax®-Direct is based upon the same platform technology as the Company's first two major product lines: DCVax®-L and DCVax®-Prostate.  Each product line involves two key ingredients:  the dendritic cells (which are activated to mobilize the immune system to attack the patient's cancer), and biomarkers of the patient's tumor (which identify the targets for the immune s
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SOURCE Northwest Biotherapeutics
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