Navigation Links
NVA237 Phase II Results Presented at the European Respiratory Society Annual Meeting Show Promising Efficacy and Tolerability With Potentially Faster Onset Than Tiotropium
Date:10/6/2008

TOKYO and CHIPPENHAM, England, October 7 /PRNewswire-FirstCall/ -- Sosei Group Corporation ("Sosei"; TSE Mothers Index: 4565) and Vectura Group plc ("Vectura"; LSE: VEC), announce results of two Phase II studies evaluating the efficacy, safety and tolerability of NVA237 presented at the annual congress of the European Respiratory Society (ERS) in Berlin, Germany. The new data show that NVA237 (glycopyrronium bromide), a novel inhaled long-acting muscarinic antagonist (LAMA), provides sustained 24-hour bronchodilation in patients with moderate-to-severe chronic obstructive pulmonary disease (COPD).

NVA237 showed similar efficacy and duration of action to tiotropium with potentially a more rapid onset of action. In addition, studies lasting up to 28 days showed that NVA237 was safe and well tolerated with no clinically relevant cardiovascular findings.

NVA237 was licensed to Novartis by Sosei and Vectura in 2005 in a deal in which the two companies could receive up to US$ 375 million in milestones as well as royalties on product sales.

COPD affects 210 million people worldwide and is projected to be the third leading cause of death by 2030. It is a progressive lung disease with symptoms including chronic bronchitis and/or emphysema which slowly progress and eventually lead to a largely irreversible loss of lung function. While there is no cure, bronchodilators such as LAMAs make breathing easier by enlarging the patient's airways, and are recognized in international guidelines as first-line treatment for COPD.

One of the randomized, double-blind, placebo-controlled studies compared NVA237 (12.5, 25, 50 and 100microg once-daily) with placebo and open-label tiotropium. In the study involving 83 patients, all doses of NVA237 showed rapid onset of action and sustained 24-hour bronchodilation over the seven-day treatment period.

Clinically relevant improvements (i.e. >120mL more than placebo) in forced expiratory volume in one seco
'/>"/>

SOURCE Sosei Group Corporation
Copyright©2008 PR Newswire.
All rights reserved

Page: 1 2 3 4 5

Related medicine technology :

1. Genaera Corporation Reports Phase 1 Data for Trodusquemine (MSI-1436) at the North American Association for the Study of Obesity Annual Meeting
2. Dendreon Announces Interim Data From Phase 3 PROVENGE IMPACT Trial
3. Dendreon to Hold a Conference Call Today at 9:00 AM ET to Provide an Update on Interim Results of Phase 3 PROVENGE IMPACT Trial
4. Pharmaleads Lead Candidate for Pain, PL37, Enters Phase I
5. Xalieve(TM) Gains Momentum as Calabar AB Launches a Phase II Repeated Dose Study in Dry Mouth Patients
6. AEterna Zentaris Reaches 2nd Stage of Patient Recruitment for Phase 2 Trial in Ovarian Cancer with the Innovative LHRH Receptor Targeted Conjugate, AEZS-108
7. Circassia Initiates Further Phase II Clinical Study of Toleromune(R) Anti-Allergy Technology
8. Ironwood Raises $50 Million to Advance Linaclotide Through Phase 3
9. Lilly Announces Initiation of Second Global Phase III Trial of Investigational Alzheimers Disease Compound
10. Bioheart Announces 35 Leading U.S. Heart Failure Centers Engaged in Phase II/III Marvel Trial of Myogenic Cells for Treating Advanced Heart Failure
11. Forest Laboratories, Inc. and Gedeon Richter Plc Announce Positive Phase II Results with the Investigational Antipsychotic Cariprazine in Patients with Acute Mania Associated with Bipolar I Disorder
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/1/2015)...   Intarcia Therapeutics, Inc. today announced the ... President, Human Resources, reporting directly to Kurt Graves ... key member of the senior leadership team, Mr. Brady ... to assure the Company advances its business, brings in ... values and its dynamic culture. Another essential goal for ...
(Date:5/1/2015)... 1, 2015 CANTEL MEDICAL CORP. (NYSE: CMN ... Executive Officer, will be presenting at the Bank of America ... Wynn in Las Vegas, NV. The ... 10:00 AM PT/1:00 PM ET. In addition, management will be ... An audio webcast will be available via the investor ...
(Date:5/1/2015)... , May 1, 2015  Portal Instruments, Inc., an ... systems, announced today that Robert Langer, Sc. D., ... University of Auckland Distinguished Professor have joined the company,s ... welcome two esteemed biotechnology leaders, Professor Robert Langer ... team," said Dr. Patrick Anquetil , Chief Executive ...
Breaking Medicine Technology:Intarcia Appoints James P. Brady Vice President, Human Resources 2Intarcia Appoints James P. Brady Vice President, Human Resources 3Intarcia Appoints James P. Brady Vice President, Human Resources 4Portal Instruments Adds Two Esteemed Biotechnology Leaders to its Scientific Advisory Board 2Portal Instruments Adds Two Esteemed Biotechnology Leaders to its Scientific Advisory Board 3Portal Instruments Adds Two Esteemed Biotechnology Leaders to its Scientific Advisory Board 4
... March 1, 2011 Practice Fusion, the ... in the US, today announced Jason Portnoy as the ... free, cloud-based EMR to physicians; enabling charting, scheduling, e-prescribing ... period of rapid expansion, bringing his deep expertise in ...
... IRVINE, Calif., March 1, 2011 Uptake Medical ® ... of lung diseases including emphysema , announced today that ... (Nasdaq: VOLC ) has joined the company,s Board ... CEO and Director of Volcano since April 2002. He led ...
Cached Medicine Technology:Former PayPal, Palantir Executive Jason Portnoy Joins Practice Fusion as CFO 2Former PayPal, Palantir Executive Jason Portnoy Joins Practice Fusion as CFO 3Uptake Medical Announces Scott Huennekens Elected to Board of Directors 2
(Date:5/3/2015)... Indiana Fiber Network, LLC (IFN), the ... Services, Inc (BCS) has selected IFN as a fiber ... technology, service, and working relationship with IFN has been ... feel you get with IFN. I like dealing ... local decisions and operates as a local community business ...
(Date:5/3/2015)... Boston, MA (PRWEB) May 03, 2015 ... received clearance from the FDA to produce and market ... This device can be used in outpatient settings and ... , The alternate posterior approach has been extensively researched ... a 510k approval to use this approach in conjunction ...
(Date:5/2/2015)... 02, 2015 Ticket Down has secured additional ... the long awaited event today, Saturday, May 2nd at the ... fans will be able to secure tickets for both the ... that boxing fans have wanted for more than five years ... “Money” Mayweather will step inside the ring to fight Manny ...
(Date:5/2/2015)... May 02, 2015 It’s a pattern ... natural disaster strikes anywhere on this planet, cyber scammers ... sympathy and compassion for their own personal gain. ... Emergency Readiness Team) issued an alert titled “Nepal ... email scams citing the earthquake in Nepal. The scam ...
(Date:5/2/2015)... Kare Visits LLC. launched in Chicago in response to the ... offers relief for caregivers by visiting loved ones in nursing ... the Caregiver Action Network, eight in ten caregivers are employed. ... caring for an elderly or disabled loved one. For ... caregiver is now empowered to schedule an on demand visit ...
Breaking Medicine News(10 mins):Health News:Bank Computer Services, Inc Selects Indiana Fiber Network, LLC as Fiber Transport Provider 2Health News:Bank Computer Services, Inc Selects Indiana Fiber Network, LLC as Fiber Transport Provider 3Health News:Cheap Floyd Mayweather vs. Manny Pacquiao Tickets: Ticket Down Has Last Minute Tickets for Mayweather vs. Pacquiao at the MGM Grand Garden Arena in Las Vegas 2Health News:Cheap Floyd Mayweather vs. Manny Pacquiao Tickets: Ticket Down Has Last Minute Tickets for Mayweather vs. Pacquiao at the MGM Grand Garden Arena in Las Vegas 3Health News:Cyber Aftershocks from Nepal’s Earthquake Can Cripple Businesses Right Here at Home 2Health News:Cyber Aftershocks from Nepal’s Earthquake Can Cripple Businesses Right Here at Home 3Health News:Cyber Aftershocks from Nepal’s Earthquake Can Cripple Businesses Right Here at Home 4Health News:Chicagoan Seeks to Transform Industry by Launching an Innovative Elderly Care Solution 2
... ... Vouchers Via Twitter to Support the Launch of the New Video Marketing Quiz. , ... (PRWEB) March 9, 2010 -- EyeView , the ... Video Marketing Quiz on Wednesday March 10, 2010 at 10 am ET. The ...
... ... combined their industry leading technologies to provide the most sensitive tools for monitoring apoptosis in ... ... have combined their industry leading technologies to provide the most sensitive tools for monitoring apoptosis ...
... ... ... ... ...
... ... ... ... ...
... when the price went up, study found , TUESDAY, March ... people consume less of it, a new study has found. , ... adults, aged 18 to 30, beginning in 1985 to 1986 and ... percent increase in price was associated with a 7 percent decrease ...
... ... employees and positive business outcomes. , ... Charlotte, NC (Vocus) March 9, 2010 -- Morehead , the ... free hour-long webinar will be broadcast on Tuesday, March 30, 2010 at 1:00 p.m. ...
Cached Medicine News:Health News:EyeView Launches Innovative Video Marketing Quiz 2Health News:EyeView Launches Innovative Video Marketing Quiz 3Health News:Promega - TOP srl Agreement Enables Live Animal Imaging for Cancer Studies 2Health News:Wanted: Indianapolis Customer Service Professionals 2Health News:Wanted: Indianapolis Customer Service Professionals 3Health News:Wanted: Indianapolis Customer Service Professionals 4Health News:Wanted: Indianapolis Customer Service Professionals 5Health News:World's First 3D Dance DVD Released! 2Health News:World's First 3D Dance DVD Released! 3Health News:Cost of Junk Food May Influence Consumption 2Health News:Morehead Webinar to Discuss Building Workforce Commitment 2
... unique DHEA-S-7kits feature a ... against the C-7 position ... with no cross-reactivity with ... RIA has been optimized ...
... based on the competition principle and the ... present in the sample and a fixed ... compete for the binding sites of a ... After one hour incubation the microtiterplate is ...
Inquire...
... It is a compact Latex based reagent kit ... well as to determine the level of RF ... patient sera. The kit includes antigen coated fine ... control sera in plastic squeezable dropping bottles, re-usable ...
Medicine Products: