Navigation Links
NVA237 Phase II Results Presented at the European Respiratory Society Annual Meeting Show Promising Efficacy and Tolerability With Potentially Faster Onset Than Tiotropium
Date:10/6/2008

TOKYO and CHIPPENHAM, England, October 7 /PRNewswire-FirstCall/ -- Sosei Group Corporation ("Sosei"; TSE Mothers Index: 4565) and Vectura Group plc ("Vectura"; LSE: VEC), announce results of two Phase II studies evaluating the efficacy, safety and tolerability of NVA237 presented at the annual congress of the European Respiratory Society (ERS) in Berlin, Germany. The new data show that NVA237 (glycopyrronium bromide), a novel inhaled long-acting muscarinic antagonist (LAMA), provides sustained 24-hour bronchodilation in patients with moderate-to-severe chronic obstructive pulmonary disease (COPD).

NVA237 showed similar efficacy and duration of action to tiotropium with potentially a more rapid onset of action. In addition, studies lasting up to 28 days showed that NVA237 was safe and well tolerated with no clinically relevant cardiovascular findings.

NVA237 was licensed to Novartis by Sosei and Vectura in 2005 in a deal in which the two companies could receive up to US$ 375 million in milestones as well as royalties on product sales.

COPD affects 210 million people worldwide and is projected to be the third leading cause of death by 2030. It is a progressive lung disease with symptoms including chronic bronchitis and/or emphysema which slowly progress and eventually lead to a largely irreversible loss of lung function. While there is no cure, bronchodilators such as LAMAs make breathing easier by enlarging the patient's airways, and are recognized in international guidelines as first-line treatment for COPD.

One of the randomized, double-blind, placebo-controlled studies compared NVA237 (12.5, 25, 50 and 100microg once-daily) with placebo and open-label tiotropium. In the study involving 83 patients, all doses of NVA237 showed rapid onset of action and sustained 24-hour bronchodilation over the seven-day treatment period.

Clinically relevant improvements (i.e. >120mL more than placebo) in forced expiratory volume in one seco
'/>"/>

SOURCE Sosei Group Corporation
Copyright©2008 PR Newswire.
All rights reserved

Page: 1 2 3 4 5

Related medicine technology :

1. Genaera Corporation Reports Phase 1 Data for Trodusquemine (MSI-1436) at the North American Association for the Study of Obesity Annual Meeting
2. Dendreon Announces Interim Data From Phase 3 PROVENGE IMPACT Trial
3. Dendreon to Hold a Conference Call Today at 9:00 AM ET to Provide an Update on Interim Results of Phase 3 PROVENGE IMPACT Trial
4. Pharmaleads Lead Candidate for Pain, PL37, Enters Phase I
5. Xalieve(TM) Gains Momentum as Calabar AB Launches a Phase II Repeated Dose Study in Dry Mouth Patients
6. AEterna Zentaris Reaches 2nd Stage of Patient Recruitment for Phase 2 Trial in Ovarian Cancer with the Innovative LHRH Receptor Targeted Conjugate, AEZS-108
7. Circassia Initiates Further Phase II Clinical Study of Toleromune(R) Anti-Allergy Technology
8. Ironwood Raises $50 Million to Advance Linaclotide Through Phase 3
9. Lilly Announces Initiation of Second Global Phase III Trial of Investigational Alzheimers Disease Compound
10. Bioheart Announces 35 Leading U.S. Heart Failure Centers Engaged in Phase II/III Marvel Trial of Myogenic Cells for Treating Advanced Heart Failure
11. Forest Laboratories, Inc. and Gedeon Richter Plc Announce Positive Phase II Results with the Investigational Antipsychotic Cariprazine in Patients with Acute Mania Associated with Bipolar I Disorder
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/22/2014)...  WaferGen Bio-systems, Inc. (NASDAQ: WGBS) today announced the ... common stock and warrants at a price of $10,000 ... to deducting underwriting discounts and commissions and offering expenses ... immediately separable and will be issued separately.  The shares ... The NASDAQ Stock Market under the ticker symbol "WGBS" ...
(Date:8/21/2014)... 2014   Memorial Hermann Health System and ... announced a new partnership to provide a new level of ... centers in the greater Houston area. ... the exclusive provider of professional breast radiology services for five ... City, The Woodlands , Northeast, Southwest and ...
(Date:8/21/2014)... Nektar Therapeutics (NASDAQ: NKTR ... results from its Phase 3 pivotal clinical trial ... factor VIII (rFVIII) treatment for hemophilia A based ... primary endpoint in reducing annualized bleed rates (ABR) ... arm. Top-line results from the prospective, ...
Breaking Medicine Technology:WaferGen Bio-Systems Announces Pricing of $20 Million Underwritten Offering and Uplisting to NASDAQ 2WaferGen Bio-Systems Announces Pricing of $20 Million Underwritten Offering and Uplisting to NASDAQ 3WaferGen Bio-Systems Announces Pricing of $20 Million Underwritten Offering and Uplisting to NASDAQ 4Memorial Hermann, MD Anderson join forces to provide enhanced breast imaging services throughout the Greater Houston Region 2Memorial Hermann, MD Anderson join forces to provide enhanced breast imaging services throughout the Greater Houston Region 3Memorial Hermann, MD Anderson join forces to provide enhanced breast imaging services throughout the Greater Houston Region 4Baxter Announces Positive Top-Line Results from Its Phase 3 Study of BAX 855, Extended Half-Life Recombinant FVIII for Hemophilia A Patients 2Baxter Announces Positive Top-Line Results from Its Phase 3 Study of BAX 855, Extended Half-Life Recombinant FVIII for Hemophilia A Patients 3Baxter Announces Positive Top-Line Results from Its Phase 3 Study of BAX 855, Extended Half-Life Recombinant FVIII for Hemophilia A Patients 4Baxter Announces Positive Top-Line Results from Its Phase 3 Study of BAX 855, Extended Half-Life Recombinant FVIII for Hemophilia A Patients 5
(Date:8/22/2014)... 22, 2014 For patients who need surgery for ... procedure is the least often used, reports a study ... , official journal of the Congress of Neurological ... Williams & Wilkins , a part of Wolters ... good pain relief at much lower cost than other ...
(Date:8/22/2014)... (PRWEB) August 22, 2014 Pirate ... expansion of products in providing new recipe cards, fun ... wear. , Hailing from Clearwater, Florida, Pirate Jonny, ... having 1 card with two to three recipes featuring ... recipes on the website. The recipe ...
(Date:8/22/2014)... Society for Medical Oncology (ESMO), the leading pan-European ... names of three outstanding individuals receiving the Society,s ... to Carsten Bokemeyer, Heikki Joensuu and Peter Boyle ... 26-30 September, Madrid, Spain. , Carsten Bokemeyer will ... accelerate the transition of cancer discovery into real ...
(Date:8/22/2014)... 22, 2014 A new study finds a wide ... may be related to key environmental exposuresin children with Crohn,s ... official journal of the Crohn,s & Colitis Foundation of ... Lippincott Williams & Wilkins , a part of Wolters ... evidence" of alterations of DNA in several regions of the ...
(Date:8/22/2014)... recall the dramatic images of nurses at New York ... hundred patients, carrying many including the youngest and most ... resulting from the storm surge generated by Hurricane Sandy. ... the New York University Colleges of Nursing (NYUCN) and ... Urban Health examines the impact on NYULMC nurses, ...
Breaking Medicine News(10 mins):Health News:More common procedures for painful facial tics carry high costs, reports study in Neurosurgery 2Health News:Pirate Jonny's Caribbean BBQ Rubs, Seasonings & Sauces Get New Look by Hoisting New Recipe Card Creations and New Clothing Apparel for its Logos 2Health News:ESMO honors outstanding oncology professionals 2Health News:ESMO honors outstanding oncology professionals 3Health News:Study shows epigenetic changes in children with Crohn's disease 2Health News:Study identifies challenges faced by NYU nurses after Hurricane Sandy 2Health News:Study identifies challenges faced by NYU nurses after Hurricane Sandy 3
... Amanda Gardner HealthDay Reporter , MONDAY, Oct. 11 ... higher risk for stroke even if they don,t have full-blown ... people who show signs of insulin resistance -- a reduction ... from the bloodstream -- may be helpful in preventing stroke, ...
... Health care in the last six months of life has ... among Medicare beneficiaries in the United States and older adults ... final six months of life in both countries, according to ... the February 14 print issue of Archives of Internal ...
... retinal conditions nearly doubled between 1997 and 2007, with ... performed, according to a report in the October issue ... JAMA/Archives journals. "Retinal disease is highly prevalent among ... diabetic retinopathy account for more than half the irreversible ...
... , MONDAY, Oct. 11 (HealthDay News) -- Pre-teens who spent ... TV or computer were at greater risk of having psychological ... kids also tended to be physically active, new research finds. ... November print issue of Pediatrics , found that the ...
... By Jenifer Goodwin HealthDay Reporter , ... have jaundice may be at higher risk of developing ... said far more research needs to be done before ... analyzed information from national registries that included all Danish ...
... disparities in the receipt of breast cancer care persist ... status. That is the conclusion of a study published ... of the American Cancer Society. The findings suggest that ... breast cancer care and to ensure that all affected ...
Cached Medicine News:Health News:Insulin Resistance Might Raise Risk of Stroke 2Health News:Insulin Resistance Might Raise Risk of Stroke 3Health News:End-of-life care patterns shift for patients with heart failure in both US and Canada 2Health News:End-of-life care patterns shift for patients with heart failure in both US and Canada 3Health News:End-of-life care patterns shift for patients with heart failure in both US and Canada 4Health News:End-of-life care patterns shift for patients with heart failure in both US and Canada 5Health News:Treatment of retinal conditions appears to have changed significantly in previous decade 2Health News:Could Excess Computer, TV Time Harm Kids Psychologically? 2Health News:Could Excess Computer, TV Time Harm Kids Psychologically? 3Health News:Danish Study Suggests Jaundice-Autism Link 2Health News:Danish Study Suggests Jaundice-Autism Link 3Health News:Insurance and socioeconomic status do not explain racial disparities in breast cancer care 2
... and fourth year medical students on ... easy access in a rapid-fire Q&A ... lab coat pocket, this reference is ... prior to surgical rounds as well ...
With its extensive content and custom-designed user interface, Schwartz Principles of Surgery, PDA Edition enables you quick access to the answers you need to make the right diagnosis or initiate a t...
This handy reference contains all of the essential information that surgical residents and medical students need to have at their fingertips for day-to-day patient care....
This book includes orthopedic, reproductive, renal, cardiovascular, GI, and respiratory problems; and other common conditions....
Medicine Products: