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NT-proBNP Guided Therapy Keeps Heart Failure Patients out of the Hospital Through a Reduction in Cardiovascular Events
Date:11/15/2010

11; a global burdenIt is estimated that as many as five million Americans have heart failure, with 400,000-500,000 new cases/year; the diagnosis carries a mortality rate that exceeds many cancers. Heart failure ranks among the most costly chronic conditions in developed countries, with the burden being greatest among the elderly. Heart failure hospitalization represents a major burden on the healthcare system both in the U.S. and the rest of the world.

Given this rapidly increasing incidence of heart failure and relative shortage of novel therapies for diagnosis, a new strategy of care utilizing existing therapies, including the intention to not only address symptoms, but also to lower NT-proBNP concentrations with the goal of reducing risk in parallel, would not only contribute to better patient outcomes, but also likely reduce healthcare costs.

About the Roche sponsored PROTECT studyPROTECT, a prospective randomized trial comparing a strategy of aggressive heart failure therapy guided by levels of a cardiac hormone—amino-terminal pro-B type natriuretic peptide (NT-proBNP)—versus standard heart failure treatment without NT-proBNP guidance has been enrolling subjects in the Heart Center at the Massachusetts General Hospital since 2006.  In December 2009 the promising results of the interim analysis supported the early closure of the study.

Besides the primary endpoint of total cardiovascular events over a one year period, other endpoints in PROTECT will include effects of NT-proBNP guidance on quality of life, effect of NT-proBNP guided care on cardiac structure and function, and overall costs of care.  Publication of the results is expected in the next few months.

About NT-proBNPTests for NT-proBNP, a cardiac hormone that is released into the blood when the heart wall is stretched, are developed and marketed by Roche. NT-proBNP was approved by the U.S. Food and Drug Administration (FDA) as an objective marker
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SOURCE Roche Diagnostics
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