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NPC, UMD Study: Factors That Cause Different Treatment Responses Are Not Well Understood or Studied
Date:11/5/2013

WASHINGTON, Nov. 5, 2013 /PRNewswire-USNewswire/ -- Although researchers and health care providers widely recognize that individuals with stage IV prostate cancer react differently to treatments, the factors that impact treatment outcomes, including biological factors such as race, age, or co-morbidities, and nonbiological factors such as geography, diet or social issues, are not well understood or studied. A study examining this issue, led by researchers from the University of Maryland School of Pharmacy and the National Pharmaceutical Council, was published today in the Journal of Comparative Effectiveness Research.

The study, The Emerging Relevance of Heterogeneity of Treatment Effect in Clinical Care: A Study Using Stage IV Prostate Cancer as a Model, examined the impact of individual treatment effects, or heterogeneity, on survival, adverse events or health-related quality of life in stage IV prostate cancer patients. As the study explains, "individual treatment effects can make it challenging for the patient and the provider to select appropriate patient-centered treatments that provide maximum clinical benefit to specific patients and subgroups."

"At a time when comparative effectiveness research is shifting into high gear in the United States, we are only just beginning to fully consider how individual patient differences and treatment preferences impact health outcomes," said Dr. C. Daniel Mullins, professor and interim chair of the Department of Pharmaceutical Health Services Research at the University of Maryland School of Pharmacy. "We understand how treatments work on average, but getting the right treatment to the right patient at the right time is paramount." 

The authors chose to study stage IV prostate cancer because researchers have found considerable
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SOURCE National Pharmaceutical Council
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