Navigation Links
NKTR-118 Shows Substantial Oral Bioavailability and Extended Half-Life in Phase 1 Clinical Data Presented at American Pain Society Meeting
Date:5/7/2008

ited States, alone.

Currently, there are no specific oral drugs approved that are indicated to treat OIC. Stool softeners or laxatives may be ineffective for many patients with OIC and they are often associated with side effects like diarrhea and stomach cramps. OBD and OIC can significantly impact quality of life and increase healthcare utilization. A meta-analysis of available randomized, placebo-controlled trials of non-cancer patients receiving opioids for moderate-to-severe pain revealed that constipation is one of the most common opioid-related side effects.(2)

Nektar PEGylation Platform

Nektar PEGylation technology can enhance the properties of therapeutic agents by increasing drug circulation time in the bloodstream, decreasing immunogenicity and dosing frequency, increasing bioavailability and improving drug solubility and stability. It can also be used to modify pharmaceutical agents to preferentially target certain systems within the body and reduce penetration of drug across the blood-brain barrier. It is a technique in which non-toxic polyethylene glycol (PEG) polymers are attached to therapeutic agents, and it is applicable to most major drug classes, including proteins, peptides, antibody fragments, small molecules, and other drugs.

Nektar PEGylation technology is also used in eight additional approved partnered products in the U.S. or Europe today, including UCB's Cimzia for Crohn's disease, Roche's PEGASYS(R) for hepatitis C and Amgen's Neulasta(R) for neutropenia.

About Nektar

Nektar Therapeutics is a biopharmaceutical company that develops and enables differentiated therapeutics with its industry-leading PEGylation and pulmonary drug development platforms. Nektar's technology and drug development expertise have enabled nine approved products for partners, which include leading biopharmaceutical companies. Nektar is also developing a robust pipeline of its own high-value therapeutics that addresses unmet me
'/>"/>

SOURCE Nektar Therapeutics
Copyright©2008 PR Newswire.
All rights reserved

0

GOOD

Page: 1 2 3 4 5 6

Related medicine technology :

1. Nektar Commences Phase 2 Trial of NKTR-118 (oral PEG-naloxol) Evaluating Efficacy and Safety as Treatment for Opioid-Induced Bowel Dysfunction
2. Positive Results for NKTR-118 (oral PEG-naloxol) Presented at American Academy of Pain Management Meeting
3. Study Shows Physician Judgment is Important in Reducing Rate of RSV-Related Hospitalizations Among High-Risk Infants
4. Community Breast Center Experience Shows Real-World Application of Breast-Specific Gamma Imaging Has Significant Impact on Clinical Care
5. Study in JAMA Shows Patients Treated With Abbotts XIENCE(TM) V Drug Eluting Stent Experience Better Outcomes Than Patients Treated With Market-Leading Drug Eluting Stent
6. FTY720, a novel oral therapy in development for MS, shows sustained benefits for the majority of patients after three years of treatment
7. Preclinical Study Presented at AACR Annual Meeting Shows Peregrines Anti-PS Immunocytokines Can Generate Protective Immune Responses in a Highly Aggressive Breast Cancer Model
8. Data Presented at AACR Annual Meeting Shows Bavituximab Equivalent Plus Docetaxel Reduces Tumor Growth By Up to 95% and Halts Metastasis in a Model of Hormone-Refractory Prostate Cancer
9. Preclinical Study Shows CTIs Brostallicins Cancer-Killing Ability Based on Genetic Profiling
10. Micromet Shows Feasibility of Subcutaneous Delivery of BiTE Antibody in Preclinical Primate Study
11. Preclinical Study Presented at AACR Annual Meeting Shows Broad Anti-Cancer Potential of Peregrines anti-PS Vascular Targeting Antibodies
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/15/2009)... Ill., Dec. 15 Fenwal Inc., a ... collection, separation, safety and availability, announced today that ... Fenwal approval to market InterSol ® platelet ... solution is a specialized product used in ... a vital blood component used to prevent or ...
(Date:12/15/2009)... YORK, Dec. 15 Reportlinker.com ... report is available in its catalogue: ... Manufacturing Industry in the U.S. and ... ,, http://www.reportlinker.com/p0167745/Surgical-and-Medical-Instrument-Manufacturing-Industry-in-the-US-and-its-International-Trade-[Q4-2009-Edition].html ,, ... Surgical and Medical Instrument Manufacturing Industry ...
(Date:12/15/2009)... Reportlinker.com announces that a ... in its catalogue: ,, Systemic ... and Market Forecasts to 2015 ... Systemic Lupus Erythematosus - Drug Pipeline ... ,, Summary ,, GlobalData, ...
Breaking Medicine Technology:Fenwal Receives FDA Approval for New Solution Used to Store Donated Blood Platelets 2Reportlinker Adds Surgical and Medical Instrument Manufacturing Industry in the U.S. and its International Trade [Q4 2009 Edition] 2Reportlinker Adds Surgical and Medical Instrument Manufacturing Industry in the U.S. and its International Trade [Q4 2009 Edition] 3Reportlinker Adds Surgical and Medical Instrument Manufacturing Industry in the U.S. and its International Trade [Q4 2009 Edition] 4Reportlinker Adds Surgical and Medical Instrument Manufacturing Industry in the U.S. and its International Trade [Q4 2009 Edition] 5Reportlinker Adds Surgical and Medical Instrument Manufacturing Industry in the U.S. and its International Trade [Q4 2009 Edition] 6Reportlinker Adds Surgical and Medical Instrument Manufacturing Industry in the U.S. and its International Trade [Q4 2009 Edition] 7Reportlinker Adds Surgical and Medical Instrument Manufacturing Industry in the U.S. and its International Trade [Q4 2009 Edition] 8Reportlinker Adds Systemic Lupus Erythematosus - Drug Pipeline Analysis and Market Forecasts to 2015 2Reportlinker Adds Systemic Lupus Erythematosus - Drug Pipeline Analysis and Market Forecasts to 2015 3Reportlinker Adds Systemic Lupus Erythematosus - Drug Pipeline Analysis and Market Forecasts to 2015 4Reportlinker Adds Systemic Lupus Erythematosus - Drug Pipeline Analysis and Market Forecasts to 2015 5Reportlinker Adds Systemic Lupus Erythematosus - Drug Pipeline Analysis and Market Forecasts to 2015 6Reportlinker Adds Systemic Lupus Erythematosus - Drug Pipeline Analysis and Market Forecasts to 2015 7Reportlinker Adds Systemic Lupus Erythematosus - Drug Pipeline Analysis and Market Forecasts to 2015 8Palatin Technologies Inc Reports Positive Bremelanotide Study 3B Improved Safety Profile with Subcutaneous Administration 13520 1Palatin Technologies Inc Reports Positive Bremelanotide Study 3B Improved Safety Profile with Subcutaneous Administration 13520 2Palatin Technologies Inc Reports Positive Bremelanotide Study 3B Improved Safety Profile with Subcutaneous Administration 13520 3Palatin Technologies Inc Reports Positive Bremelanotide Study 3B Improved Safety Profile with Subcutaneous Administration 13520 4Nfocus Neuromedical Obtains CE Approval for New Vascular Reconstruction Device 54292 1Nfocus Neuromedical Obtains CE Approval for New Vascular Reconstruction Device 54292 2The Wonder 28R 29 You Love Now Offers Even More of the Nutrition You Need Wonder Classic and Wonder Classic Sandwich Provide Even More Calcium and N 54290 1The Wonder 28R 29 You Love Now Offers Even More of the Nutrition You Need Wonder Classic and Wonder Classic Sandwich Provide Even More Calcium and N 54290 2
(Date:12/16/2009)... rush Hallmark Cards have announced a great addition to one ... easy to navigate website at www.hallmark.co.uk/specialoccasions , customers can now ... own words and photos and then order as many copies of ... ... Bradford, UK (PRWEB) December 16, 2009 -- Just in time for ...
(Date:12/16/2009)... The holidays are rapidly approaching and what would be the perfect ... stem cells, of course! Celebrity Beauty Engineer® and Licensed Esthetician Mary ... how to look and feel their best! , ... ... what kind of gift does a person get that special woman ...
(Date:12/16/2009)... for your loved ones this holiday season, give them the gift ... running, child care, and pet care through Delegate Source. , ... ... the Denver and Boulder metro areas have the opportunity to give ... by using Delegate Source,s " Give a Gift " program to ...
(Date:12/15/2009)... The failure of the U.S. Senate ... costs, much less the more effective direct bulk ... example of how big industry controls the health ... drug amendment by Senator Dorgan (D-ND) was a ... pledge to allow Medicare to directly negotiate discounts ...
(Date:12/15/2009)... For Preserving State Authority, Ban on Annual Benefit ... Dec. 15 Consumer Watchdog condemned the ... over 55 and the public option from the ... said that the Senate must still make three ... prevent ceding the entire health care system to ...
Breaking Medicine News(10 mins):Health News:The UK's Biggest Card Retailer Takes Choice and Value Personally 2Health News:The UK's Biggest Card Retailer Takes Choice and Value Personally 3Health News:The UK's Biggest Card Retailer Takes Choice and Value Personally 4Health News:New Online Beauty Store Suggests Stem Cells for the Woman Who Has Everything 2Health News:Give the Gift of Service This Holiday Season with Delegate Source 2Health News:Give the Gift of Service This Holiday Season with Delegate Source 3Health News:Failure of Drug Importation Amendment in U.S. Senate is Latest Show of Industry's Controlling Hand in Health Reform Debate, According to Consumer Watchdog 2Health News:Failure of Drug Importation Amendment in U.S. Senate is Latest Show of Industry's Controlling Hand in Health Reform Debate, According to Consumer Watchdog 3Health News:The 'Big 3' Fixes for the Weakened Senate Health Reform Bill to Block Full Insurance Co. Take-Over of Health System 2Health News:The 'Big 3' Fixes for the Weakened Senate Health Reform Bill to Block Full Insurance Co. Take-Over of Health System 3Health News:The 'Big 3' Fixes for the Weakened Senate Health Reform Bill to Block Full Insurance Co. Take-Over of Health System 4Health News:The 'Big 3' Fixes for the Weakened Senate Health Reform Bill to Block Full Insurance Co. Take-Over of Health System 5
... 12, 2007) -- The University of South Floridas global ... fight AIDS has been strengthened with a $1.36-million research ... , USF Health received the five-year grant Sept. 11 ... interdisciplinary training program focused on the biomedical, behavioral, cultural ...
... of a handful nationwide interlinking ... alternative fertility care, SAN RAMON, Calif., Sept. 12 ... Area, one of nation,s oldest IVF practices,launches "Fertile Awakenings," ... a team of traditional western fertility specialists and,complementary and ...
... Maine, Sept. 12 JHA has released the results,of ... This leading,benchmarking survey reports group Long Term Disability (LTD) ... results for the first,half of the year. The thirty ... the top twenty carriers, as ranked by inforce premium,in ...
... Than $600,000 for Kidney Disease Awareness and ... Prevention ... leading,provider of dialysis services for those diagnosed with chronic kidney,failure and ... country who were supported with contributions from their,local regions will participate ...
... and a spot on a beach. You think to yourself, ... finished Moby Dick. And I get seasick! A fascinating new ... we long for something intensely like a much-needed vacation ... leading to some out-of-character choices. Similarly, when we are especially ...
... in adults depends on the steady work of a vital ... Dartmouth Medical School cancer geneticists have found. Their research ... adult blood-forming system, and opens novel strategies for targeting the ... leukemia. , We have identified a new pathway that ...
Other Medicine News:Health News:Global Health Project targets reducing AIDS among India's adolescents 2Health News:Bay IVF Experts Launch One of First East-West Fertility Programs of Its Kind 2Health News:Bay IVF Experts Launch One of First East-West Fertility Programs of Its Kind 3Health News:JHA Releases 2007 U.S. Group Disability Mid-Year Market Survey Results 2Health News:DaVita Teammates Bicycling 230 Miles for Kidney Disease Education 2Health News:Wanting a bite of everything: Hungry people crave more variety 2Health News:Unique role for blood formation gene identified 2
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
Medicine Products: