Navigation Links
NKTR-102 Shows High Response Rate and Sustained Duration of Response in Women with Platinum-Resistant/Refractory Ovarian Cancer Previously Treated with Doxil®
Date:6/5/2011

4

4

4Previous Platinum Regimens  1

13%

35%

24%  2

56%

24%

39%  3

25%

18%

21%  4+

6%

24%

15%Prior bevacizumab

6%

24%

15%Prior gemcitabine

56%

59%

58%Prior taxane

100%

100%

100%TABLE 2. Efficacy Results: Objective Response Rates by RECIST and GCIG in Subpopulation Receiving Prior Treatment with PLDNKTR-102NKTR-102145 mg/m2  q14d145 mg/m2q21dRECISTN (evaluable)16

14Confirmed + Unconfirmed

4 (25%)

4 (29%)Confirmed

3 (19%)

3 (21%)Duration of Confirmed Response (months, range)

4.2 (3-14)

4.4 (3-9)GCIGN (evaluable)

16

17Confirmed + Unconfirmed

8 (50%)

6 (35%)Confirmed

6 (38%)

6 (35%)CA-125N (evaluable)

15

14Confirmed

6 (40%)

5 (36%)*Only patients with measurable disease/CA-125 at baseline were considered evaluable.TABLE 3. Safety Results in Subpopulation Receiving Prior Treatment with PLDMost Common Drug-related Grade 3 and 4

Adverse Events > 5% or event of interest

N (%) NKTR-102

145 mg/m2

q14d

N=16

NKTR-102

145 mg/m2

q21d

N=17Grade 3

Grade 4

Grade 3

Grade 4Diarrhea

5 (31%)

0

3 (18%)

0Hypokalemia

5 (31%)

1 (6%)

0

0Nausea

5 (31%)

0

1 (6%)

0Dehydration

3 (19%)

0

1 (6%)

0Fatigue

1 (6%)

0

3 (18%)

0Vomiting

4 (25%)

0

0

0Neutropenia

1 (6%)

0

1 (6%)

1 (6%)Anaemia

2 (12.5%)

0

0

0Decreased appetite

1 (6%)

0

1 (6%)

0Hyponatraemia

2 (13%)

0

0

0Lymphophenia

1 (6%)

0

1 (6%)

0Note: There wa
'/>"/>

SOURCE Nektar Therapeutics
Copyright©2010 PR Newswire.
All rights reserved

Page: 1 2 3 4 5 6 7 8

Related medicine technology :

1. NKTR-102 Demonstrates Sustained Clinical Benefit in 46% of Patients with Metastatic Breast Cancer in Data Presented at 2011 American Society of Clinical Oncology Annual Meeting
2. Nektar Announces New Phase 2 Data for NKTR-102 to Be Presented at 2011 ASCO Annual Meeting
3. FDA Grants Orphan Drug Designation for Nektars Investigational Drug, NKTR-102, for Treatment of Women with Ovarian Cancer
4. NKTR-102 Demonstrates Significant Efficacy as Single-Agent in Second- or Third-Line Treatment in Metastatic Breast Cancer Patients
5. NKTR-102 Shows Encouraging Anti-Tumor Activity in Ovarian Cancer in Phase 1 and Preclinical Data Presented at the ECCO 15 and 34th ESMO Multidisciplinary Congress
6. Nektar Announces Expanded Phase 2 Clinical Development Plan For NKTR-102 (PEG-irinotecan)
7. Nektar to Webcast Presentation of Phase 1 Clinical Results for Lead Small Molecule PEG-Oncolytic Program, NKTR-102 (PEG-irinotecan)
8. Significant Anti-Tumor Activity of NKTR-102 in Patients With Refractory Solid Tumors; Interim Data Published in ASCO 2008 Proceedings
9. Additive Anti-Tumor Activity of NKTR-102 in Combination With Bevacizumab Highlighted in Positive Preclinical Data Presented at AACR Meeting
10. Nektar Commences Phase 2 Clinical Development Program for NKTR-102 (PEG-Irinotecan) in Colorectal Cancer
11. NKTR-102 (PEG-Irinotecan) Demonstrates Significant Tumor Growth Inhibition In Multiple Preclinical Tumor Models
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/30/2014)... --  NxStage® Kidney Care, Inc ., a subsidiary of NxStage® ... host the grand opening ceremony of its Oak ... Street on November 20, 2014 from 3pm – 7pm. The ... who are committed to providing patients with enhanced access to ... through more flexible dialysis treatment options.   The ...
(Date:10/30/2014)... Calif. , Oct. 30, 2014  Electronic ... dramatically as a result of government initiatives and ... - healthcare providers have invested over the past ... heart of health IT, and U.S. clinicians use ... Logo - http://photos.prnewswire.com/prnh/20141029/155278LOGO ...
(Date:10/30/2014)... 2014  Nektar Therapeutics (Nasdaq: NKTR ) ... ended September 30, 2014 on Thursday, November 6, 2014, ... Robin , president and chief executive officer, will host ... 5:00 p.m. Eastern Time (ET)/2:00 p.m. Pacific Time (PT). ... audio-only Webcast of the conference call can be accessed ...
Breaking Medicine Technology:Grand Opening of NxStage Kidney Care Oak Brook IL Center 2Grand Opening of NxStage Kidney Care Oak Brook IL Center 3Electronic Health Record Usability: CIOs Weigh In 2Electronic Health Record Usability: CIOs Weigh In 3Electronic Health Record Usability: CIOs Weigh In 4Nektar to Announce Financial Results for the Third Quarter 2014 on Thursday, November 6, 2014, After Close of U.S.-Based Financial Markets 2
(Date:10/30/2014)... 30, 2014 REV'D Provision Co. announced ... available through a unique service called, The Feed ... empower the everyday athlete. The Feed has taken the ... created a system to pass that information on to ... is now available on The Feed!” says REV’D® marketing ...
(Date:10/30/2014)... The Woodlands, TX (PRWEB) October 30, 2014 ... hospital system, released today its 2014 third quarter ... hospitals across Texas boasted infection rates of only ... also reported patient satisfaction scores exceeding 98 percent. ... this past quarter, which included rising satisfaction scores,” ...
(Date:10/30/2014)... (HealthDay News) -- Scientists who used stem cells to ... breakthrough could provide a new way to learn more ... The team used human pluripotent stem cells -- which ... -- to grow the functional miniature stomachs, to study ... cause of ulcers and stomach cancer. The miniature ...
(Date:10/30/2014)... -- Many U.S. colleges have indoor tanning salons ... the risk for skin cancer, researchers report. ... women, so colleges should adopt tanning-free policies, to ... "Public health efforts are needed to raise university ... that indoor tanning poses to young adults in ...
(Date:10/30/2014)... 2014 (HealthDay News) -- A new vaccine that could ... was approved by the U.S. Food and Drug Administration ... between the ages of 10 and 25 from invasive ... B bacteria. The bacteria can infect the bloodstream ... and brain. It is a leading cause of bacterial ...
Breaking Medicine News(10 mins):Health News:Nutrition Experts at TheFeed.com Get REV'D 2Health News:Nutrition Experts at TheFeed.com Get REV'D 3Health News:Victory Healthcare Releases Q3 Satisfaction, Infection Rates 2Health News:Victory Healthcare Releases Q3 Satisfaction, Infection Rates 3Health News:Many U.S. Colleges Have Indoor Tanning Salons On, Near Campus: Study 2Health News:FDA Approves New Vaccine to Protect Against Meningitis 2
... (ZixCorp(R)), (Nasdaq: ZIXI ), the leader in hosted ... corporate update by its chief executive officer, Rick Spurr. , ... ZixCorp and we are on target to report within the ... are that we should meet our revenue guidance of $7.3 ...
... 7 The National Inflation Association today released the following ... , "It is becoming increasingly likely that health care will ... There is no doubt about it that health care costs ... the government to do something about astronomical health care costs, ...
... , ,PROVIDENCE, R.I. [Brown University] Fueling the debate ... or repressed memory, Brown University political scientist Ross Cheit ... issue is how to prove whether the memories of ... and then resurface later in life. Cheit,s paper, co-authored ...
... Providence Service Corporation (Nasdaq: PRSC ) today commented ... state,s attempt to close its large budget deficit. ... our programs in California are primarily funded by Medicaid and ... do not expect to experience material funding issues for our ...
... study findings , TUESDAY, July 7 (HealthDay News) -- ... findings that show a reduced-dose schedule for the pneumococcal ... , The current recommended dose schedule for 7-valent pneumococcal ... the age of 6 months, followed by a booster ...
... less pain with conventional operation , TUESDAY, July 7 (HealthDay ... that can be caused by sciatica didn,t work as well ... expected treatment benefit of a faster rate of recovery from ... double-blind study," according to a report in the July 8 ...
Cached Medicine News:Health News:Zix Corporation CEO Provides Corporate Update for Second Quarter 2009 2Health News:Zix Corporation CEO Provides Corporate Update for Second Quarter 2009 3Health News:Zix Corporation CEO Provides Corporate Update for Second Quarter 2009 4Health News:NIA Says Health Care Will Cause U.S. Dollar Collapse 2Health News:NIA Says Health Care Will Cause U.S. Dollar Collapse 3Health News:Brown professor continues debate over recovered memory 2Health News:Providence Service Corporation Does Not Expect California Budget Issues to Materially Impact Its Business in the State 2Health News:Fewer Shots Could Still Protect Kids From Pneumonia 2Health News:Minimally Invasive Surgery Not Better for Sciatica 2Health News:Minimally Invasive Surgery Not Better for Sciatica 3
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
Medicine Products: