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NKTR-102 Shows High Response Rate and Sustained Duration of Response in Women with Platinum-Resistant/Refractory Ovarian Cancer Previously Treated with Doxil®
Date:6/5/2011

tment with PLD represent a very high unmet medical need as there are currently no good treatment options available for these women.  These results demonstrate that NKTR-102 holds great therapeutic potential for women battling ovarian cancer.  We look forward to the continued late-stage development of NKTR-102." 

NKTR-102 was generally well tolerated in the subset of women with prior PLD treatment, particularly in the q21 dose schedule.  The most common Grade 3 and 4 side effects were diarrhea, hypokalemia, and nausea, with most side effects being Grade 3 in severity. [Table 3.]

NKTR-102 Phase 2 Data Presentation in Ovarian Cancer

  • The role of NKTR-102 in women with platinum resistant/refractory ovarian cancer and failure on pegylated liposomal doxorubicin (PLD).
    Abstract #5047, Poster Board #15C
    General Poster Session:  Gynecologic Cancer
    Session Date and Time:  Sunday, June 5, 2011, 8:00 AM – 12:00 PM, Central Time
    Location:  Hall A

  • The NKTR-102 Phase 2 Study was an international, multicenter, open-label, randomized, two-stage study to evaluate NKTR-102 when given either on a q14d or q21d regimen in women with platinum-resistant/refractory disease to any line of platinum-based chemotherapy (platinum-free interval <6 months).  46 percent (33/71) of the women in the study had failed prior treatment with PLD.  Median lines of prior therapy for this subpopulation of women enrolled in the study were 4.  The primary endpoint of the study was objective response rate (based on RECIST and GCIG response criteria).  Secondary endpoints were safety, progression-free survival and overall survival.  TABLE 1. Patient Demographics: Prior Therapies in Subpopulation Receiving Prior Treatment with PLDNKTR-102

    145 mg/m2 q14d

    (N=16)

    NKTR-102

    145 mg/m2 q21d

    (N=17)

    Total (N=33)Prior Lines of Therapy (median)


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    SOURCE Nektar Therapeutics
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