NKTR-102 Shows Encouraging Anti-Tumor Activity in Ovarian Cancer in Phase 1 and Preclinical Data Presented at the ECCO 15 and 34th ESMO Multidisciplinar...(ecan in a platinum-resistant 2780 ovaria...),Health

Date:9/22/2009

ecan in a platinum-resistant 2780 ovarian cancer mouse model. NKTR-102 showed clear superiority over irinotecan at all dose levels, with 100% of animals demonstrating partial or complete tumor regression with NKTR-102 compared to only 1 of 10 animals with a partial response at the highest irinotecan dose. NKTR-102 was also better tolerated than irinotecan at all doses tested.

Data were also presented on patients with recurrent ovarian cancer from the Phase 1 dose-escalation study of single agent NKTR-102. Of five patients with ovarian cancer in the study, two were evaluable for efficacy. Both patients showed significant anti-tumor activity, including tumor reductions of up to 37% and a decrease in CA-125 marker levels of up to 80%. These patients had failed multiple prior therapies and had progressed following prior platinum-based therapy. Pharmacokinetic data from this same Phase 1 study showed increased and sustained SN38 exposure with administration of NKTR-102 compared to expected SN38 levels following irinotecan administration.

Phase 2 Study of NKTR-102 in Platinum-Resistant Ovarian Cancer Commences Second Stage

The company also announced today that a phase 2 study evaluating two dose regimens (q14 and q21 days) of single-agent NKTR-102 in patients with platinum-resistant ovarian cancer is ongoing. Enrollment of the first stage of this two-stage study is complete for both regimens (20 patients per regimen).

Data Presentation for NKTR-102

The poster presentation from today's "Gynecologic Cancer Session" at the ECCO15/ESMO 34 2009 Multidisciplinary Conference can be found on Nektar's website. www.nektar.com/product_pipeline/oncology_nktr-102.html

Poster 161 - Abstract 8015: Hoch et al.,"NKTR-102 Demonstrates Nonclinical and Phase 1 Clinical Anti-tumor Activity in Ovarian Cancer"

About NKTR-102

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