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NKTR-102 Demonstrates Sustained Clinical Benefit in 46% of Patients with Metastatic Breast Cancer in Data Presented at 2011 American Society of Clinical Oncology Annual Meeting
Date:6/4/2011

0

0Neutropenic sepsis

0

0

1 (3%)

0Febrile neutropenia

0

0

1 (3%)

0Note: There were two possible treatment-related deaths: sepsis (q21d) and acute renal failure following diarrhea (q14d).  

Figure E: Safety Table: Other Safety-Neuropathy and AlopeciaNo grade 3 or 4 neuropathy was reported.NKTR-102

145 mg/m2

q14d

N=35

NKTR-102

145 mg/m2

q21d

N=35Grade 1

Grade 2

Grade 1

Grade 2Alopecia

6 (20%)

0

3 (9%)

1 (3%)About Metastatic Breast CancerMore than one million women worldwide are diagnosed with breast cancer globally every year(1).  The chance of developing invasive breast cancer at some time in a woman's life is a little less than one in eight (12%).  There are approximately 200,000 new cases of breast cancer in the United States and 430,000 in Europe each year.(2)  Metastatic breast cancer refers to cancer that has spread from the breast to distant sites in the body.  

Anthracyclines and taxanes (AT) are the most active and widely used chemotherapeutic agents for breast cancer, but the increased use of these agents at an early stage of disease often renders tumors resistant to these drugs by the time the disease recurs, thereby reducing the number of treatment options for metastatic disease.  Drugs used to treat patients who progress following AT treatment can have response rates as high as 20-30%; however, resistance develops rapidly and new agents with different mechanisms of action, such as topoisomerase I inhibitors, are needed to allow novel ways to overcome the problem of drug resistance. (3)  There are currently no FDA-approved topoisomerase I inhibitors to treat breast cancer.

About NKTR-102 Nektar is developing NKTR-102, a next-generation topoisomerase I inhibitor with reduced peak concentrations and a continuous concentration profi
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SOURCE Nektar Therapeutics
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