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NKTR-102 Demonstrates Sustained Clinical Benefit in 46% of Patients with Metastatic Breast Cancer in Data Presented at 2011 American Society of Clinical Oncology Annual Meeting
Date:6/4/2011

bout the future of this new anticancer drug candidate," said Lorianne Masuoka, M.D., Senior Vice President and Chief Medical Officer.  

Side effects were generally manageable with dose-limiting toxicity consisting primarily of Grade 3 diarrhea (20-23%) typically occurring after three months of therapy for both schedules.   Neuropathy and alopecia were minimal with only one patient experiencing G2 alopecia in the study.  Both neuropathy and alopecia are significant adverse events commonly associated with standard breast cancer therapies [Safety Tables, Figures D and E].

NKTR-102 Phase 2 Data Presentation in Metastatic Breast Cancer

  • Awada et. al., Antitumor activity in a randomized phase II study comparing two schedules of NKTR-102 in patients (Pts) with pretreated metastatic breast cancer (MBC).Abstract #1034, Poster Board #24Poster Discussion Session:  Breast Cancer - Triple-negative/Cytotoxics/Local Therapy  Session Date and Time:  Saturday, June 4, 2011, 2:00 PM – 6:00 PM, Central TimeLocation:  E450bFigure A: Efficacy Table: Objective Tumor Response Rate by RECIST (Investigator Assessment)Response by RECIST v 1.0NKTR-102145 mg/m2q14d NKTR-102145 mg/m2q21d TOTALN

    31*

    35

    66ORR (confirmed + unconfirmed)

    11 (35%)

    11 (31%)

    22 (33%)ORR (confirmed)

    10 (32%)

    9 (26%)

    19 (29%)CR (confirmed)

    2 (7%)

    0

    2 (3%)PR (confirmed)

    8 (26%)

    9 (26%)

    17 (26%)SD

    12 (39%)

    16 (46%)

    28 (42%)PD

    9 (29%)

    10 (29%)

    19 (29%)Median duration of response

    8.3 months

    4.4 months

    5.8 monthsClinical benefit

    (CR+PR+SD>6 months)

    13 (42%)

    17 (49%)

    30 (46%)Median progression-free survival**

    3.5 months

    5.3 months

    4.6 monthsMedian overall survival**

    8.8 months

    13.1 months

    10.3 months
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  • SOURCE Nektar Therapeutics
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