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NKTR-102 Demonstrates Significant Efficacy as Single-Agent in Second- or Third-Line Treatment in Metastatic Breast Cancer Patients
Date:12/12/2010

p>NKTR-102

145 mg/m²

q21d

N=35TOTALER+ and/or PR+

ORR (confirmed)

8/21 (38%) 4/21 (19%)12/42 (29%)Triple-negative breast cancer

ORR (confirmed)

2/8 (25%)

5/10 (50%)

7/18 (39%)Visceral Disease

ORR (confirmed)

8/25 (32%)

9/33 (27%)17/58 (29%)Figure D: Safety Table: Safety-Summary of Drug Related AEsMost Common Drug-related Grade 3 and 4 Adverse Events > 5% or event of interest N (%) NKTR-102

145 mg/m²

q14d

N=35

NKTR-102

145 mg/m²

q21d

N=35Grade 3

Grade 4

Grade 3

Grade 4Diarrhea

6 (17%)

1 (3%)

8 (23%)

0Neutropenia

2 (6%)

2 (6%)

3 (9%)

1 (3%)Fatigue

4 (11%)

0

3 (9%)

0Dehydration

2 (6%)

0

3 (9%)

0Asthenia

2 (6%)

0

0

0Lymphopenia

2 (6%)

0

0

0Vomiting

2 (6%)

0

0

0Neutropenic sepsis

0

0

1 (3%)

0Febrile neutropenia

0

0

1 (3%)

0Note: 2 treatment-related deaths: sepsis (q21d) and acute renal failure following diarrhea (q14d).  Figure E: Safety Table: Other Safety-Neuropathy and AlopeciaNo grade 3 or 4 neuropathy was reported.NKTR-102

145 mg/m²

q14d

N=35

NKTR-102

145 mg/m²

q21d

N=35Grade 1

Grade 2

Grade 1

Grade 2Alopecia

6 (17%)

0

3 (9%)

1 (3%)About Metastatic Breast CancerMore than one million women worldwide are diagnosed with breast cancer globally every year (1).  The chance of developing invasive breast cancer at some time in a woman's life is a little less than one in eight (12%).  Anywhere from 30% to 80% of women with breast cancer develop metastatic disease.  Metastatic breast cancer refers to cancer that has spread from the b
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SOURCE Nektar Therapeutics
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