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NKTR-102 Demonstrates Significant Efficacy as Single-Agent in Second- or Third-Line Treatment in Metastatic Breast Cancer Patients
Date:12/12/2010

on to the webcast at least fifteen minutes prior to the scheduled start time.  A replay of this investor event will be available on the Nektar website approximately three hours after the presentation and will be archived for four weeks.

Figure A: Efficacy Table: Objective Tumor Response Rate by RECIST (Investigator Assessment)Response by RECIST v 1.0

NKTR-102

145 mg/m²

q14d

ITT/Evaluable

NKTR-102

145 mg/m²

q21d ITT/EvaluableTOTAL

ITT/EvaluableN

35/31*

35

70/66ORR (confirmed + unconfirmed

11 (31%)/11 (35%)

11 (31%)

22 (31%)/22 (33%)ORR (confirmed)

10 (29%)/10 (32%)

9 (26%)

19 (27%)/19 (29%)CR (confirmed)

2 (6%)/2 (7%)

0

2 (3%)/2 (3%)PR (confirmed)

8 (23%)/8 (26%)

9 (26%)

17 (24%)/17 (26%)SD

17 (48%)/13 (42%)

17 (48%)

34 (49%)/30 (45%)PD

8 (23%)/8 (26%)

9 (26%)

17 (24%)/17 (26%)Clinical benefit

(CR+PR+SD greater than or equal to 6 months)

12 (34%)/12 (39%)

15 (43%)

27 (38%)/27 (41%)*4 patients in the Q14 day arm with no post-baseline scans, but no evidence of progression were excluded from analysis in the evaluable population.Figure B: Efficacy Table: Response rate by prior therapyPrior Therapy Subgroup

Response by RECIST v 1.0

Evaluable PatientsNKTR-102

145 mg/m²

q14d

N=31

NKTR-102

145 mg/m²

q21d

N=35TOTALPrior A/T only

ORR (confirmed)

7/22 (32%) 5/21 (24%)12/43 (28%)Prior A/T in MBC

ORR (confirmed)

2/6 (33%)

2/8 (25%)

4/14 (29%)Prior A/T/C

ORR (confirmed)

2/6 (33%)

3/9 (33%)5/15 (33%)Figure C: Efficacy Table: Response rate by tumor characteristicsDisease Subgroup

Response by RECIST v 1.0

Evaluable PatientsNKTR-102

145 mg/m²

q14d

N=31

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SOURCE Nektar Therapeutics
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