Navigation Links
NKTR-102 (PEG-Irinotecan) Demonstrates Significant Tumor Growth Inhibition In Multiple Preclinical Tumor Models
Date:10/25/2007

ffective halflife of the metabolite was increased from 15 hours with irinotecan to 6 days with NKTR-102.

This increased and prolonged metabolite exposure following administration of NKTR-102 was associated with its anti-tumor activity in lung and colorectal models using pharmacokinetic (PK) and pharmacodynamic (PD) modeling. Further, PK/PD simulations performed with irinotecan administration show that a continuous infusion of irinotecan at 240 mg/kg would be required to achieve the equivalent tumor exposure of the active metabolite and associated tumor growth inhibition found with NKTR-102. This 240 mg/kg dose of irinotecan would be expected to cause significant mortality in mice.

Data Presentations

The two poster presentations made today at the AACR-NCI-EORTC International Conference, and prior presentations for NKTR-102, can be found on Nektar's website at http://www.nektar.com/wt/page/nktr102media

C10: "NKTR-102, a novel polyethylene glycol conjugate of irinotecan, has improved antitumor activity in three mouse xenograft models"

C157: "NKTR-102, a novel PEGylated-irinotecan conjugate, results in sustained tumor growth inhibition in mouse models of human colorectal and lung tumors that is associated with increased and sustained SN38 exposure"

About NKTR-102

Nektar is developing NKTR-102, a PEGylated form of irinotecan, which was invented by Nektar using its world-leading small molecule PEGylation technology platform. The product is currently in Phase 1 clinical development. Irinotecan is an important chemotherapeutic agent used for the treatment of solid tumors, including colorectal and lung cancers. By applying Nektar's small molecule PEGylation technology to irinotecan, NKTR-102 may prove to be a more powerful and tolerable anti-tumor agent.

Nektar PEGylation Platform

Nektar PEGylation technology can enhance the properties of therapeutic a
'/>"/>

SOURCE Nektar Therapeutics
Copyright©2007 PR Newswire.
All rights reserved

Page: 1 2 3 4 5

Related medicine technology :

1. The International Myeloma Foundation Says Data Reported at a Global Medical Meeting in Greece Demonstrates Improved Survival for a Wide Range of Myeloma Patients
2. Publication on Pixantrone Preclinical Studies Demonstrates Reduced Cardiotoxicity Compared to Equiactive Doses of Doxorubicin and Mitoxantrone
3. New Research Demonstrates Broad Efficacy of Azixa (MPC-6827) Against Multiple Tumor Types and in Drug Resistant Cell Lines
4. Algeta Demonstrates Targeted Cancer-killing Potential of Novel Alpha Particle Linked Antibodies in Leading Medical Journal Blood
5. Gerons Telomerase Inhibitor Cancer Drug Demonstrates Good Pharmacokinetics and Tolerability in Phase I/II Trial
6. Frova Phase III Study Data Demonstrates That Short-Term Prevention Treatment Reduces Frequency and Severity of Menstrual Migraine
7. Mymetics HIV Vaccine Demonstrates First-Ever Production of Neutralizing IgA Antibodies in Non-Human Primate Model
8. Cipralex demonstrates superiority to duloxetine for acute treatment of depression in new study
9. Newly Published Data Demonstrates Superiority of Cipralex Over Duloxetine for Acute Treatment of Depression
10. Introgens Advexin Demonstrates Clinical Benefit in Inherited Cancer
11. Prostate Cancer: Clinical Study Demonstrates Superior Efficacy of Docetaxel Chemotherapy
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/18/2014)... Kan. , Sept. 18, 2014  Aratana ... pet therapeutics company focused on licensing, developing and ... announced the full exercise of the underwriters, option ... in connection with the company,s previously announced public ... of the shares are being offered by Aratana ...
(Date:9/18/2014)... LINCOLN, Neb. , Sept. 18, 2014   ... ONC HIT 2014 Edition Complete EHR certification, which designates ... with meeting the Stage 1 and Stage 2 Meaningful ... American Recovery and Reinvestment Act (ARRA).  MacPractice MD MU ... ICSA Labs , an Office of the National ...
(Date:9/18/2014)... DUBLIN , Sept. 18, 2014 ... the "China PTCA Balloon Market Investment Report, 2014-2016" ... balloon, as a indispensable medical device in percutaneous coronary ... for stent, but also as a device for pre-/post-stent ... closely related to that of PCI. As ...
Breaking Medicine Technology:Aratana Therapeutics, Inc. Announces Full Exercise of Underwriters' Option to Purchase Additional Shares 2MacPractice MD MU Achieves ONC HIT 2014 Edition Complete EHR Certification from ICSA Labs 2MacPractice MD MU Achieves ONC HIT 2014 Edition Complete EHR Certification from ICSA Labs 3MacPractice MD MU Achieves ONC HIT 2014 Edition Complete EHR Certification from ICSA Labs 4MacPractice MD MU Achieves ONC HIT 2014 Edition Complete EHR Certification from ICSA Labs 5China PTCA Balloon Market Investment Report, 2014-2016 2China PTCA Balloon Market Investment Report, 2014-2016 3
... Oct. 19 Reportlinker.com announces that a new market ... Lung Cancer Drug Futures ... SERVICE INCLUDING FORMATS TO MEET EVERY INFORMATION NEED ... meet differing information requirement of customers. For constant vigilance ...
... 19 Reportlinker.com announces that a new market research ... Prostate Cancer Drug Futures http://www.reportlinker.com/p0315764/Prostate-Cancer-Drug-Futures.html ... INCLUDING FORMATS TO MEET EVERY INFORMATION NEED ... differing information requirement of customers. For constant vigilance and ...
Cached Medicine Technology:Reportlinker Adds Lung Cancer Drug Futures 2Reportlinker Adds Lung Cancer Drug Futures 3Reportlinker Adds Lung Cancer Drug Futures 4Reportlinker Adds Lung Cancer Drug Futures 5Reportlinker Adds Lung Cancer Drug Futures 6Reportlinker Adds Lung Cancer Drug Futures 7Reportlinker Adds Lung Cancer Drug Futures 8Reportlinker Adds Lung Cancer Drug Futures 9Reportlinker Adds Lung Cancer Drug Futures 10Reportlinker Adds Lung Cancer Drug Futures 11Reportlinker Adds Lung Cancer Drug Futures 12Reportlinker Adds Prostate Cancer Drug Futures 2Reportlinker Adds Prostate Cancer Drug Futures 3Reportlinker Adds Prostate Cancer Drug Futures 4Reportlinker Adds Prostate Cancer Drug Futures 5Reportlinker Adds Prostate Cancer Drug Futures 6Reportlinker Adds Prostate Cancer Drug Futures 7Reportlinker Adds Prostate Cancer Drug Futures 8Reportlinker Adds Prostate Cancer Drug Futures 9Reportlinker Adds Prostate Cancer Drug Futures 10
(Date:9/19/2014)... Indiana Fiber Network, LLC (IFN), the ... of its Fiber Transport Services, adding Point of Presence ... establishing a PoP at Cermak, IFN enables interconnect opportunities ... high bandwidth fiber transport service to US and Global ... President of Sales and Marketing August Zehner, establishing a ...
(Date:9/19/2014)... Mount Pleasant Retirement Village has partnered with ... Coach Christi Hall to campus. , Hall’s journey to a ... gaining weight as a result of years of medication. Through ... nutrition. One year later she had lost 50 pounds, lowered ... and cardio. , After joining the YMCA staff, she furthered ...
(Date:9/19/2014)... Newport News, Va. (PRWEB) September 19, 2014 ... at Warwick Forest, a skilled nursing center that offers rehabilitation ... But they will this weekend when a young couple marries ... together and with their combined 140 years of marriage have ... , Sarah Horky, 18, and Dan Eads, 20, may ...
(Date:9/18/2014)... 19, 2014 Today, Zane Benefits, the ... why to switch employees to individual health insurance. ... be more familiar with traditional, group health insurance, there ... employees happier. , The new article provides the ... health insurance rather than group health insurance, and why ...
(Date:9/18/2014)... OR (PRWEB) September 18, 2014 Active ... 50 and older as fully participating members of society ... lifestyle. To celebrate, The Stafford – a boutique retirement ... 97034 – will host two screenings of Cyber-Seniors - ... excited for our residents to watch this great film,” ...
Breaking Medicine News(10 mins):Health News:Indiana Fiber Network Launches Point-Of-Presence in Chicago Data Center at Cermak 2Health News:Mount Pleasant Retirement Village Partners with Atrium Family YMCA 2Health News:Mount Pleasant Retirement Village Partners with Atrium Family YMCA 3Health News:Young Couple Inspired by Residents Of The Gardens At Warwick Forest To Wed There Saturday 2Health News:Young Couple Inspired by Residents Of The Gardens At Warwick Forest To Wed There Saturday 3Health News:Zane Benefits Publishes New Information on Why Employees Are Happier with Individual Health Insurance 2Health News:In Support of Active Aging Week, a Lake Oswego Retirement Community Will Get a Sneak Peek at an Inter-Generational Documentary – Cyber-Seniors 2
... leaders in diagnosing and treating Lyme disease, has launched a new website ... treatment and cure of this highly debated disease. , ... Havertown, PA ... launched a new web site today that is dedicated to giving advanced, ...
... been named president of RetireSafe, a national bipartisan, non-profit ... the options and benefits of retired and retiring Americans ... He has served as a member of the ... providing leadership in multiple areas that engage all facets ...
... patient-centered CERWASHINGTON, May 19 Joining ... the New Democrat Coalition, Tony Coelho, chairman of ... with reporters and announced PIPC,s support for the ... an important step forward for patients and caregivers, ...
... small study , , TUESDAY, May 19 (HealthDay News) -- ... restored blood flow to hearts with blocked arteries for ... reported. , "I think this is very good news ... line and have no options left," said Dr. Douwe ...
... /PRNewswire-FirstCall/ - MDS Nordion, a leading provider of ... its primary supplier, Atomic Energy of Canada Limited ... medical isotopes, primarily molybdenum-99 (Mo-99) used in the ... MDS Nordion that they anticipate the National Research ...
... First, New York State nonprofit outpatient clinics ... Medicaid, Medicaid managed care, Medicare, and insurance billing ... healthiest organization. Millin Associates ( www.millinmedical.com ... for 27 years, provides expanded services and next-generation ...
Cached Medicine News:Health News:Haverford Wellness Center Launches Web Site Devoted to Accurate Diagnosis and Proper Treatment to Cure Lyme Disease 2Health News:Haverford Wellness Center Launches Web Site Devoted to Accurate Diagnosis and Proper Treatment to Cure Lyme Disease 3Health News:RetireSafe Names Thair Phillips as President 2Health News:PIPC Supports New Comparative Effectiveness Research (CER) Bill 2Health News:Stem Cells May Offer New Way to Treat Blocked Arteries 2Health News:Stem Cells May Offer New Way to Treat Blocked Arteries 3Health News:MDS Nordion Provides Update on AECL's Medical Isotope Supply Disruption 2Health News:MDS Nordion Provides Update on AECL's Medical Isotope Supply Disruption 3Health News:Nonprofit Outpatient Clinics and Social Service Agencies Outsource Billing to Increase Profits 2
The new Shandon HistocentreTM 3 is an integral part of the workflow in Histology laboratories, representing a workstation that complements any automatic tissue processor....
Shandon HistoWave is the answer to rapid tissue processing. It reduces time for fixation, tissue processing, decalification, immunochemistry and special stains....
The HypercleanTM 1 is a versatile, durable fume handling station. The Hyperclean 1 fume handling station unit comes complete with one (1) blower unit and one (1) charcoal filter....
... 2 fume containment system ... benchtop equipment. Even large ... inside the Hyperclean 2. ... system unit comes complete with ...
Medicine Products: