Navigation Links
NKTR-102 (PEG-Irinotecan) Demonstrates Significant Tumor Growth Inhibition In Multiple Preclinical Tumor Models
Date:10/25/2007

Anti-Tumor Activity of NKTR-102 Associated With Increased and Sustained

Exposure of Tumor Tissue to the Active Metabolite of Irinotecan

SAN FRANCISCO, Oct. 25 /PRNewswire-FirstCall/ -- Nektar Therapeutics (Nasdaq: NKTR) presented positive preclinical data today on its proprietary product candidate NKTR-102 (PEG-irinotecan) at the AACR-NCI-EORTC International Conference in San Francisco, California. The presentations highlighted the anti-tumor activity and unique pharmacokinetic profile of NKTR-102 in preclinical models of colorectal, lung and breast cancer. NKTR-102 is a PEGylated form of irinotecan developed using Nektar's innovative small molecule PEGylation technology platform and is in Phase 1 clinical development for the treatment of solid tumors.

In the two data presentations today, NKTR-102 inhibited tumor growth by greater than 90% in mouse xenograft models of colorectal (HT29), lung (NCI- H460) and breast (MCF-7) cancers as compared to controls. The studies also demonstrate that Nektar's small molecule PEGylation technology improves the pharmacokinetics of irinotecan by increasing the effective half-life of irinotecan's active metabolite in tumor tissues. In a colorectal cancer model, the half-life was increased to 15 days following NKTR-102 administration versus 4 hours following irinotecan.

"The studies presented today at the 2007 AACR-NCI-EORTC Conference highlight the superior tumor suppression properties of NKTR-102 relative to irinotecan in colorectal, lung and breast cancer models," stated Hoyoung Huh, M.D., Ph.D., Chief Operating Officer and Head of the PEGylation Business Unit at Nektar. "NKTR-102 demonstrates improved half-life and tumor exposure to irinotecan's active metab
'/>"/>

SOURCE Nektar Therapeutics
Copyright©2007 PR Newswire.
All rights reserved

Page: 1 2 3 4 5

Related medicine technology :

1. The International Myeloma Foundation Says Data Reported at a Global Medical Meeting in Greece Demonstrates Improved Survival for a Wide Range of Myeloma Patients
2. Publication on Pixantrone Preclinical Studies Demonstrates Reduced Cardiotoxicity Compared to Equiactive Doses of Doxorubicin and Mitoxantrone
3. New Research Demonstrates Broad Efficacy of Azixa (MPC-6827) Against Multiple Tumor Types and in Drug Resistant Cell Lines
4. Algeta Demonstrates Targeted Cancer-killing Potential of Novel Alpha Particle Linked Antibodies in Leading Medical Journal Blood
5. Gerons Telomerase Inhibitor Cancer Drug Demonstrates Good Pharmacokinetics and Tolerability in Phase I/II Trial
6. Frova Phase III Study Data Demonstrates That Short-Term Prevention Treatment Reduces Frequency and Severity of Menstrual Migraine
7. Mymetics HIV Vaccine Demonstrates First-Ever Production of Neutralizing IgA Antibodies in Non-Human Primate Model
8. Cipralex demonstrates superiority to duloxetine for acute treatment of depression in new study
9. Newly Published Data Demonstrates Superiority of Cipralex Over Duloxetine for Acute Treatment of Depression
10. Introgens Advexin Demonstrates Clinical Benefit in Inherited Cancer
11. Prostate Cancer: Clinical Study Demonstrates Superior Efficacy of Docetaxel Chemotherapy
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/24/2014)... ANDOVER, Mass. , July 24, 2014   ... pulmonary function testing (PFT) employing precise ultrasound technology, announced ... as the instrument to measure Carbon Monoxide Diffusing Capacity ... Study, the most comprehensive study of Chronic Obstructive Pulmonary ... leading cause of death in the U.S. and affects ...
(Date:7/24/2014)... and VANCOUVER, British Columbia ... (NASDAQ: OGXI ) announced today that the ... on Thursday, August 7, 2014, and that the Company ... 4:30 p.m. ET that afternoon. Management will provide an ... a general business update. To access ...
(Date:7/23/2014)... Australia , July 24, 2014 ... Melbourne , the agreement seeks to increase access ... At the AIDS 2014 conference in ... a new licensing agreement with Gilead Sciences for tenofovir alafenamide ... The licence will allow manufacturers in India ...
Breaking Medicine Technology:EasyOne Pro from ndd Medical Technologies Chosen Again as the Exclusive PFT Testing Technology in Phase 2 of COPDGene Study 2OncoGenex to Report Financial Results for Second Quarter 2014 on August 7, 2014 2The Medicines Patent Pool (MPP) Broadens Collaboration with Gilead Sciences: Signs Licence for Phase III Medicine Tenofovir Alafenamide (TAF) 2The Medicines Patent Pool (MPP) Broadens Collaboration with Gilead Sciences: Signs Licence for Phase III Medicine Tenofovir Alafenamide (TAF) 3
... Medical has been at the cutting edge of ... famous Resusci Anne in 1960. Fifty years on, ... launches its latest SimMan patient simulator, SimMan® Essential. ... (Photo: http://www.newscom.com/cgi-bin/prnh/20100830/NY56743 ) ...
... accelerating pace of scientific discovery in life sciences, coupled ... of genetic information, the field of personalized medicine has ... predictive and preventative care utilizing diagnostics that allow physicians ... therapeutic regimes are most effective, and determine long-term susceptibility ...
Cached Medicine Technology:Laerdal Introduces SimMan Essential 2Laerdal Introduces SimMan Essential 3Personalized Medicine: Conference Provides Update on Progress and Prospects 2
(Date:7/24/2014)... CA (PRWEB) July 24, 2014 On October ... ones will descend upon the Embassy Suites LAX North for ... hosted by DiabetesSisters and the first time it has convened ... time for the organization to open the entire event to ... the only conference of its kind worldwide for women with ...
(Date:7/24/2014)... July 24, 2014 (HealthDay News) -- A new formulation ... from snorting or injecting the drug has been approved ... Targiniq ER and made by Purdue Pharma, the pill ... a drug that blocks the euphoric effects of oxycodone. ... crushed, snorted, dissolved or injected, according to the FDA. ...
(Date:7/24/2014)... 24, 2014 Skirt Sports, the innovative women’s ... of the running skirt. Born from an idea by professional ... an Ironman race in 2004, this one innovative piece of ... prize money from her victory in Wisconsin to incorporate Skirt ... specific athletic skirts. , “When I drew the first sketch ...
(Date:7/24/2014)... July 24, 2014 The North American Omega ... omega 3 & structured lipids market in North America with ... is estimated to grow from around $762.4 million in 2012 ... from 2013 to 2018. , Browse through the TOC of ... to get an idea of the in-depth analysis provided. This ...
(Date:7/24/2014)... (PRWEB) July 24, 2014 The ... to announce a new distribution agreement with game ... collaboration between the two groups to offer ... clinicians using biofeedback and neurofeedback in European and ... “video game” developed expressly to be used as ...
Breaking Medicine News(10 mins):Health News:DiabetesSisters Brings Conference for Women with Diabetes Los Angeles for the First Time 2Health News:DiabetesSisters Brings Conference for Women with Diabetes Los Angeles for the First Time 3Health News:FDA Approves Hard-to-Abuse Narcotic Painkiller 2Health News:Skirt Sports Celebrates Its 10-Year Anniversary and 10 Years of the Running Skirt With a Virtual Community Building Run 2Health News:Skirt Sports Celebrates Its 10-Year Anniversary and 10 Years of the Running Skirt With a Virtual Community Building Run 3Health News:North America Omega 3 & Structured Lipids (Nutraceuticals) Market is Expected to Reach $1,117 million in 2018 - New Report by MicroMarket Monitor 2Health News:North America Omega 3 & Structured Lipids (Nutraceuticals) Market is Expected to Reach $1,117 million in 2018 - New Report by MicroMarket Monitor 3Health News:North America Omega 3 & Structured Lipids (Nutraceuticals) Market is Expected to Reach $1,117 million in 2018 - New Report by MicroMarket Monitor 4Health News:North America Omega 3 & Structured Lipids (Nutraceuticals) Market is Expected to Reach $1,117 million in 2018 - New Report by MicroMarket Monitor 5Health News:Biofeedback Federation of Europe Enters Distribution Agreement with Zukor Interactive 2Health News:Biofeedback Federation of Europe Enters Distribution Agreement with Zukor Interactive 3
... are seeing the first signs of a reverse brain ... grow over time. The emergence of modern,corporate and investorowned ... NRI doctors back to home turf. ,And unlike other ... the main draw, doctors are actually taking pay cuts ...
... together will build the worlds first "all digital ... by the out patient surgical rehabilitation chain. The ... screens connected to the Internet, electronic medical records ... permitting doctors and other caregivers to access patients' ...
... in the United States of America, says that children suffer ... an unhappy marriage and avoid a divorce for the sake ... only do more damage to the kids, the authors of ... of Pennsylvania State University in University Park conducted the exhaustive ...
... giants has just begun. After waging wars over many drug ... treatment. The ball was set in motion by the dramatic ... AIDS treatment would cost less than a U.S. dollar a ... announced plans of its own production of anti retroviral drugs ...
... humour. It stirred up a controversy. Now it is being ... officially announced that the advertisement in question might not be ... they did not enjoy the advertisement poking fun at organ ... a carousel horse. A team of medics approaches him and ...
... the tedious process of finding survivors of the Gujarat quake, from ... more survivors. They are now concentrating in clearing the rubble and ... far. A miracle baby was saved after nearly 90 hours under ... holding on to the dead body of its mother. The baby ...
Cached Medicine News:Health News:Lure of the home turf brings back NRI doctors 2
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
Medicine Products: