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NHLBI Grant Awarded to Wake Forest, Pitt to Improve Banked Blood
Date:12/4/2009

Kim-Shapiro.

Drs. Gladwin and Kim-Shapiro have successfully collaborated during the last 10 years to evaluate how the nitric oxide, a molecule that causes blood vessels to dilate, interacts with hemoglobin in red blood cells. Their new grant, which was awarded by the National Heart, Lung and Blood Institute of the National Institutes of Health, aims to examine the role of oxidative damage, micro-particle formation and red cell destruction--both during blood storage and after transfusion -- in lab, animal and human studies; to explore key enzymes in the nitric oxide biochemical pathway; and to develop treatments to improve the quality and function of stored blood.

The Vascular Medicine Institute was founded in 2008 with the support of the Institute for Transfusion Medicine, which has sites in Pittsburgh and Chicago, and the Hemophilia Center of Western Pennsylvania.

As one of the nation's leading academic centers for biomedical research, the University of Pittsburgh School of Medicine integrates advanced technology with basic science across a broad range of disciplines in a continuous quest to harness the power of new knowledge and improve the human condition. Driven mainly by the School of Medicine and its affiliates, Pitt has ranked among the top 10 recipients of funding from the National Institutes of Health since 1997 and now ranks fifth in the nation, according to preliminary data for fiscal year 2008. Likewise, the School of Medicine is equally committed to advancing the quality and strength of its medical and graduate education programs, for which it is recognized as an innovative leader, and to training highly skilled, compassionate clinicians and creative scientists well-equipped to engage in world-class research. The School of Medicine is the academic partner of UPMC, which has collaborated with the University to raise the standard of medical excellence in Pittsburgh and to position health care as a driving force behind the
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