Navigation Links
NHLBI Grant Awarded to Wake Forest, Pitt to Improve Banked Blood
Date:12/4/2009

WINSTON-SALEM, N.C., Dec. 4 /PRNewswire-USNewswire/ -- A new, $2.8 million, four-year federal grant will support researchers at the University of Pittsburgh School of Medicine and their collaborators at Wake Forest University as they study why the quality of stored transfusion blood degrades over time and how to address the problem. This "storage lesion," as scientists call it, has been associated with increased risk for cardiovascular events and organ failure, particularly among compromised patients who receive multiple units of aged blood.

There is strong evidence that red blood cells lose some of their enzyme function and have a shortened life span during the time they are banked, explained co-principle investigator Mark Gladwin, M.D., director of the Vascular Medicine Institute at the University of Pittsburgh and chief of the division of pulmonary, allergy and critical care medicine at the School of Medicine.

"When the red cells hemolyze, or break apart, during storage, they leave behind micro-particle remains and the hemoglobin they contained," Dr. Gladwin said. "We suspect that after transfusion those remains lead to destruction of nitric oxide, which in turn can cause blood vessel inflammation and narrowing, as well as blood clots."

In a paper published last month in the early, online version of Current Opinion in Hematology, he and co-principal investigator Daniel B. Kim-Shapiro, Ph.D., professor of physics, Harbert Family Distinguished Chair, and director of the Translational Science Center at Wake Forest, reviewed experiments that show even low levels of red cell micro-particles and free hemoglobin scavenge nitric oxide, severely reducing its bioavailability.

"It's possible that an agent that increases nitric oxide levels, such as sodium nitrite, could be added to banked blood or given directly to transfusion patients to compensate for the potential complications of a storage lesion," noted Dr.
'/>"/>

SOURCE Wake Forest University
Copyright©2009 PR Newswire.
All rights reserved

Page: 1 2 3

Related medicine technology :

1. ADVENTRX Announces Fast Track Designation Granted By the FDA For CoFactor For the Treatment of Metastatic Colorectal Cancer
2. Pharmion and MethylGene Announce U.S. Orphan Drug Designation Granted for MGCD0103 for the Treatment of Hodgkins Lymphoma
3. Advanced Life Sciences Announces ALS-357 Granted FDA Orphan Drug Designation for Metastatic Melanoma
4. US FDA Grants Orphan Drug Status to Immtechs Pafuramidine for Treatment of African Sleeping Sickness
5. Chinese SFDA Grants Immtech Fast Track Status
6. Taxotere(R) (docetaxel) Granted FDA Approval to Treat Locally Advanced Head and Neck Cancer Prior to Chemoradiotherapy and Surgery
7. Virogenomics, Inc. Awarded $2 Million National Institute of Standards and Technology (NIST) Advanced Technology Program Grant to Develop Integrated Diagnostic Biosensors
8. Aptivus(R) (tipranavir) Capsules Granted Full Approval by the U.S. FDA
9. Authorization for AGENDA Phase 3 Trial of Genasense(R) in Advanced Melanoma Granted by French Regulatory Agency
10. Ethics Group Asks USAID Inspector General to Investigate Legality of Grants to Soros Groups
11. Emphasys Medical Granted Expedited Review From FDA for Zephyr(R) Endobronchial Valve
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/15/2014)... today announced it has established a relief fund ... that has gripped much of the nation. AARP and its ... support these emergency relief efforts AARP and AARP Foundation will ... to $500,000 in aid. The matching program will be administered ...
(Date:1/15/2014)... THOUSAND OAKS, Calif. , Jan. 15, 2014 ... and Amgen (NASDAQ: AMGN ) announced ... to jointly discover and validate new therapeutic targets ... (IBD), a chronic disorder that affects millions worldwide. ...
(Date:1/15/2014)... , January 15, 2014 BreedIT ... the exclusive worldwide distributor of highly sophisticated agro-breeding solutions ... January 7, 2014, the Company,s board of directors appointed ... as its new member of the board. ...
Breaking Medicine Technology:AARP Foundation Establishes Winter Relief Fund for Older Adults Suffering from the Severe Cold Weather 2AARP Foundation Establishes Winter Relief Fund for Older Adults Suffering from the Severe Cold Weather 3Mass. General, Broad Institute and Amgen Will Work to Discover New Drugs for Inflammatory Bowel Disease 2Mass. General, Broad Institute and Amgen Will Work to Discover New Drugs for Inflammatory Bowel Disease 3Mass. General, Broad Institute and Amgen Will Work to Discover New Drugs for Inflammatory Bowel Disease 4BreedIT (OTC: BRDT) Appoints Chemistry and Pharmaceutical Industry Expert Dr. Ben-Zion Weiner to Its Board of Directors 2BreedIT (OTC: BRDT) Appoints Chemistry and Pharmaceutical Industry Expert Dr. Ben-Zion Weiner to Its Board of Directors 3
... 2011 The New Jersey Patient Care and Access Coalition ... encourages men and their families to speak out to preserve ... Force (USPSTF) recommended healthy men should no longer receive prostate-specific ... This decision was made by a panel ...
... 2011 Masimo (NASDAQ: ... Japanese Ministry of Health Labor & Welfare (MHLW) ... rainbow® Acoustic Monitoring technology—providing noninvasive and continuous acoustic ... and enhance patient compliance.  Available for the first ...
Cached Medicine Technology:NJ Docs Say Cancer Detection Tool Saves Lives 2Masimo rainbow Acoustic Monitoring Technology Cleared for Market in Japan 2Masimo rainbow Acoustic Monitoring Technology Cleared for Market in Japan 3Masimo rainbow Acoustic Monitoring Technology Cleared for Market in Japan 4Masimo rainbow Acoustic Monitoring Technology Cleared for Market in Japan 5Masimo rainbow Acoustic Monitoring Technology Cleared for Market in Japan 6
(Date:4/17/2014)... presence of chronic inflammation in benign prostate tissue ... and this association was found even in those ... a study published in Cancer Epidemiology, Biomarkers ... Association for Cancer Research. , An analysis of ... the placebo arm of the Prostate Cancer Prevention ...
(Date:4/17/2014)... study published today in PLOS Pathogens , children ... is common can mount an immune response to infection ... repeated bouts of high fever and illness and partially ... The findings may help researchers develop future interventions that ... parasite. , Each year, approximately 200 million cases of ...
(Date:4/17/2014)... Le Bonheur Children,s Hospital Pediatrician-in-Chief Jon McCullers, MD, ... the April issue of Nature Reviews Microbiology ... Dr. McCullers, a world-renowned infectious disease specialist, ... the University of Tennessee Health Science Center, analyzed ... 1918, 1957 and 1968 pandemics, as well as ...
(Date:4/17/2014)... (April 16, 2014) The cause of neuronal death ... study proposes that neurons may be mistaken for foreign ... similar to the way autoimmune diseases like type I ... cells. The study was published April 16, 2014, in ... and likely controversial, idea in Parkinson,s disease; but if ...
(Date:4/17/2014)... An international team led by researchers at UC Davis ... plays a key role in cell division, also boosts ... the first time the complex has been shown to ... B1/Cdk1 an excellent target to control cellular energy production, ... was published online today in the journal Developmental ...
Breaking Medicine News(10 mins):Health News:Chronic inflammation may be linked to aggressive prostate cancer 2Health News:Chronic inflammation may be linked to aggressive prostate cancer 3Health News:Study sheds light on how the immune system protects children from malaria 2Health News:Is Parkinson's an autoimmune disease? 2Health News:Dual role: Key cell division proteins also power up mitochondria 2
... of decline over past decade , , MONDAY, Oct. 15 (HealthDay ... across the United States, offering what an expert called a ... a new report, cancer death rates fell by 2.1 percent ... 1.1 percent annual decline recorded between 1993 and 2003. , ...
... 15, 2007 Post-hoc and other analyses of secondary ... Shire plc,s (LSE: SHP, NASDAQ: SHPGY, TSX: SHQ) ulcerative ... LIALDA in patients with mild to moderate ulcerative colitis. ... III, open-label 12-14 month extension study, are being presented ...
... LOGAN, Utah, Oct. 15 Facet Solutions, Inc. ... on the first cohort of,patients to receive its ... these patients at one year include a significant,decline ... function; and no,post-operative complications. Additionally, the first patient ...
... Patients with obstructive sleep apnea (OSA) who also ... continuous positive airway pressure (CPAP) relieves them of symptoms ... October 15 issue of the Journal of Clinical Sleep ... Sleep Center at Universitys Community Hospital in Tampa, Fla., ...
... schedules now routine and,the initial excitement over, lunches will ... a good time to re-evaluate menus and discuss healthier,choices ... The following are suggestions from the experts at ... nutritional impact. Add a,handful of trail mix and fresh ...
... have on average a 71 percent lower chance of ... lowest-rated hospitals across 18 procedures and conditions analyzed in ... issued today by HealthGrades, the healthcare ratings company. The ... of care between the highest-performing hospitals and all others, ...
Cached Medicine News:Health News:U.S. Cancer Death Rate Continues to Fall 2Health News:U.S. Cancer Death Rate Continues to Fall 3Health News:New Analyses of long-term LIALDA (mesalamine) data presented at ACG 2Health News:New Analyses of long-term LIALDA (mesalamine) data presented at ACG 3Health News:New Analyses of long-term LIALDA (mesalamine) data presented at ACG 4Health News:Facet Solution's AFRS(TM) Implant Demonstrates Positive Clinical Results After One Year Follow Up 2Health News:Fresh, Tasty - Healthy - Lunch and Snack Ideas 2Health News:Mortality rates 71 percent lower at top-rated hospitals: HealthGrades 2008 hospital-quality study 2Health News:Mortality rates 71 percent lower at top-rated hospitals: HealthGrades 2008 hospital-quality study 3
... 1300 C is ideal for evaluating a wide ... parts of the body. Often referred to at ... magnetocardiography, gastrointestinal tract, fetal, spinal cord and peripheral ... C, with its 67 detector coils, covers a ...
... table configurations designed for a wide range ... capture 17 X 17 X-ray images from ... system includes a Bucky table, upright tilting ... suspended multi-positioning unit. Versatile and economical, the ...
... synthetic bone filler tailored for slow ... and Hydroxyapatite (HAP), its composition mimics ... the chemistry and microstructure of Bi-Ostetic ... provides optimal osteo-conduction. The spongy Bi-Ostetic ...
The TB Lead is a high quality bipolar intracardiac lead for cost effective temporary pacing and electrophysiology studies. The TB lead is available in sizes ranging from 4F to 6F and comes in either ...
Medicine Products: