Navigation Links
NHLBI Grant Awarded to Wake Forest, Pitt to Improve Banked Blood
Date:12/4/2009

WINSTON-SALEM, N.C., Dec. 4 /PRNewswire-USNewswire/ -- A new, $2.8 million, four-year federal grant will support researchers at the University of Pittsburgh School of Medicine and their collaborators at Wake Forest University as they study why the quality of stored transfusion blood degrades over time and how to address the problem. This "storage lesion," as scientists call it, has been associated with increased risk for cardiovascular events and organ failure, particularly among compromised patients who receive multiple units of aged blood.

There is strong evidence that red blood cells lose some of their enzyme function and have a shortened life span during the time they are banked, explained co-principle investigator Mark Gladwin, M.D., director of the Vascular Medicine Institute at the University of Pittsburgh and chief of the division of pulmonary, allergy and critical care medicine at the School of Medicine.

"When the red cells hemolyze, or break apart, during storage, they leave behind micro-particle remains and the hemoglobin they contained," Dr. Gladwin said. "We suspect that after transfusion those remains lead to destruction of nitric oxide, which in turn can cause blood vessel inflammation and narrowing, as well as blood clots."

In a paper published last month in the early, online version of Current Opinion in Hematology, he and co-principal investigator Daniel B. Kim-Shapiro, Ph.D., professor of physics, Harbert Family Distinguished Chair, and director of the Translational Science Center at Wake Forest, reviewed experiments that show even low levels of red cell micro-particles and free hemoglobin scavenge nitric oxide, severely reducing its bioavailability.

"It's possible that an agent that increases nitric oxide levels, such as sodium nitrite, could be added to banked blood or given directly to transfusion patients to compensate for the potential complications of a storage lesion," noted Dr.
'/>"/>

SOURCE Wake Forest University
Copyright©2009 PR Newswire.
All rights reserved

Page: 1 2 3

Related medicine technology :

1. ADVENTRX Announces Fast Track Designation Granted By the FDA For CoFactor For the Treatment of Metastatic Colorectal Cancer
2. Pharmion and MethylGene Announce U.S. Orphan Drug Designation Granted for MGCD0103 for the Treatment of Hodgkins Lymphoma
3. Advanced Life Sciences Announces ALS-357 Granted FDA Orphan Drug Designation for Metastatic Melanoma
4. US FDA Grants Orphan Drug Status to Immtechs Pafuramidine for Treatment of African Sleeping Sickness
5. Chinese SFDA Grants Immtech Fast Track Status
6. Taxotere(R) (docetaxel) Granted FDA Approval to Treat Locally Advanced Head and Neck Cancer Prior to Chemoradiotherapy and Surgery
7. Virogenomics, Inc. Awarded $2 Million National Institute of Standards and Technology (NIST) Advanced Technology Program Grant to Develop Integrated Diagnostic Biosensors
8. Aptivus(R) (tipranavir) Capsules Granted Full Approval by the U.S. FDA
9. Authorization for AGENDA Phase 3 Trial of Genasense(R) in Advanced Melanoma Granted by French Regulatory Agency
10. Ethics Group Asks USAID Inspector General to Investigate Legality of Grants to Soros Groups
11. Emphasys Medical Granted Expedited Review From FDA for Zephyr(R) Endobronchial Valve
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/22/2014)... Research and Markets ( http://www.researchandmarkets.com/research/hmlfbq/investment ... "Investment Analysis of the US Medical Device Sector ... http://photos.prnewswire.com/prnh/20130307/600769 This ... sector identifies the key trends and rationale for ... mergers and acquisitions. The study will ...
(Date:12/22/2014)... CHESTERBROOK, Pa. and STOCKHOLM ... AB (publ) (Sobi) and partner Auxilium Pharmaceuticals, Inc. today ... Use (CHMP) of the European Medicines Agency (EMA) has ... (collagenase clostridium histolyticum) for the treatment of adult men ... deformity of at least 30 degrees at the start ...
(Date:12/22/2014)... 2014  Eiger BioPharmaceuticals Incorporated announced the positive ... in patients with chronic hepatitis delta virus (HDV) ... Institutes of Health (NIH) Clinical Center in ... placebo-controlled, dose ascending study evaluated two doses of ... twice daily for 28 days.  "This proof-of-concept study ...
Breaking Medicine Technology:Investment Analysis of the US Medical Device Sector 2Sobi's Xiapex receives positive opinion by CHMP for the treatment of Peyronie's disease 2Sobi's Xiapex receives positive opinion by CHMP for the treatment of Peyronie's disease 3Sobi's Xiapex receives positive opinion by CHMP for the treatment of Peyronie's disease 4Sobi's Xiapex receives positive opinion by CHMP for the treatment of Peyronie's disease 5Sobi's Xiapex receives positive opinion by CHMP for the treatment of Peyronie's disease 6Eiger Bio Announces Positive Data in Patients Infected with Hepatitis Delta Virus (HDV) Treated with Lonafarnib - Results Presented at American Association for the Study of Liver Diseases (AASLD) Meeting 2Eiger Bio Announces Positive Data in Patients Infected with Hepatitis Delta Virus (HDV) Treated with Lonafarnib - Results Presented at American Association for the Study of Liver Diseases (AASLD) Meeting 3
... 2011 Royal Philips Electronics (AEX: PHI, NYSE: ... with Integrated Oncology Network, LLC (ION), a development, practice ... quality in oncology. Building on its existing strength in ... and IT solutions for oncology, this partnership signals Philips, ...
... Pharmaceuticals, a provider of global contract manufacturing services for ... into an agreement with an undisclosed pharmaceutical company for ... diagnostic aid. Stuart Hinchen, president and CEO ... with comprehensive experience in manufacturing site transfers put us ...
Cached Medicine Technology:Philips Teams up With Integrated Oncology Network, Reinforcing Its Commitment to the Future of Cancer Care 2Philips Teams up With Integrated Oncology Network, Reinforcing Its Commitment to the Future of Cancer Care 3Philips Teams up With Integrated Oncology Network, Reinforcing Its Commitment to the Future of Cancer Care 4JHP Pharmaceuticals Enters Agreement to Produce Diagnostic Aid 2
(Date:12/22/2014)... Luxury Linen purveyor Peacock Alley once ... to provide logistics and support for one of Dallas’ largest ... long history of giving back to the community in which ... Toy Drive were Whataburger® and 99.5 The Wolf. , There ... Providing gifts to children who would otherwise not receive any ...
(Date:12/22/2014)... NAPW honors Michelle ... the Year. Ms. Foley is recognized with this prestigious ... networking organization of professional women in the country, spanning ... Professional Women is a powerfully vibrant networking community with ... “As a nurse, I felt like I made a ...
(Date:12/22/2014)... BROOK, Ill. (PRWEB) December 21, 2014 ... radiologist recommendations for chest computed tomography (CT) to ... clinically relevant findings, including cancer, according to a ... , Researchers said the findings show that ... X-rays represent valuable contributions to patient care. , ...
(Date:12/22/2014)... DC (PRWEB) December 22, 2014 ... Leadership Conference, next month in San Antonio, ... to address dynamics that often stand in the ... and competition. , This premier faculty development ... for Transformational Leadership, whose mission is to assist ...
(Date:12/21/2014)... In this report, the global powered surgical instruments ... application. The market, by power source, is segmented ... the market covers the handpieces; power source and ... further subdivided into drills, saws, reamers, staplers, vessel ... drivers, and others. Moreover, the power source and ...
Breaking Medicine News(10 mins):Health News:Peacock Alley and Community Partners of Dallas Fulfill an Estimated 12,000 Holiday Wishes for Deserving Children 2Health News:National Association of Professional Women Announces Michelle M. Foley, Vice President of Operations of OTTR Chronic Care Solutions, a 2014 Professional Woman of the Year 2Health News:RSNA: Radiologist Recommendations for Chest CT Have High Clinical Yield 2Health News:RSNA: Radiologist Recommendations for Chest CT Have High Clinical Yield 3Health News:2015 NLN Leadership Conference February 5-7 San Antonio 2Health News:2015 NLN Leadership Conference February 5-7 San Antonio 3Health News:Global Powered Surgical Instruments Market Hit to $2.1 billion by 2019 - New Research Report by MarketsandMarkets 2Health News:Global Powered Surgical Instruments Market Hit to $2.1 billion by 2019 - New Research Report by MarketsandMarkets 3Health News:Global Powered Surgical Instruments Market Hit to $2.1 billion by 2019 - New Research Report by MarketsandMarkets 4
... found measurable gains in those with moderate to severe ... implanting specialized cells found in the human eye into ... were able to reduce symptoms and improve quality of ... The new treatment, dubbed Spheramine, reduced symptoms experienced when ...
... thing for a typical adolescent and quite another to ... an adult world. A unique program, the Indiana University ... Conditions of Childhood (CYACC) is helping these youths spread ... pediatricians at Riley Hospital for Children have been at ...
... leads PRO collection in community ... ... Oncology Services,(SOS), Inc. a research-based health-outcomes company specializing in,oncology, issued the ... cancer community., "Appropriate use of PRO information in the community ...
... Unites Hospitals to Reduce Critical Care Physician Shortage, Improve Care ... ... WASHINGTON, April 28 Today, six hospitals serving,patients in rural ... the VISICU eICU(R) Program in each of their,intensive care units. Made ...
... been chosen as the recipient of the 2008 Alzheimer ... recognition of his outstanding work, "Phagocytosis of amyloid-beta and ... by M. Fiala, D.H. Cribbs, M. Rosenthal and G. ... Associate Editors of the journal select an outstanding article ...
... N.J., April 28 Milestone,Scientific Inc. (OTC Bulletin Board: MLSS), the recognized ... its award winning STA(TM) System at the upcoming,California Dental Association (CDA) 2008 ... May 4, 2008, WHERE: Booth #1641 ... 800 West Katella Avenue ...
Cached Medicine News:Health News:Eye Cell Implants Improve Parkinson's Symptoms 2Health News:Eye Cell Implants Improve Parkinson's Symptoms 3Health News:Transitioning patients with pediatric disease to adulthood 2Health News:Systematic Review of Patient-Reported Outcomes (PROs) Can Reduce Cost of Cancer Care 2Health News:Rural Maryland Hospitals Form Unprecedented Collaborative to Improve Patient Care 2Health News:Rural Maryland Hospitals Form Unprecedented Collaborative to Improve Patient Care 3Health News:Milan Fiala, MD, receives 2008 Alzheimer Award 2Health News:Milestone Scientific to Exhibit at the California Dental Association (CDA) Spring Scientific Session 2Health News:Milestone Scientific to Exhibit at the California Dental Association (CDA) Spring Scientific Session 3Health News:Milestone Scientific to Exhibit at the California Dental Association (CDA) Spring Scientific Session 4
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
Medicine Products: