Navigation Links
NAFLD AND NASH Linked to Metabolic Syndrome and Cardiovascular Disease
Date:4/23/2008

Patients With Fatty Liver are at Increased Risk of Cardiovascular Disease

Prevalence Estimates Vary Widely, and Approach 25% Among Adults Risk Factors for Fatty Liver Include Overweight, Type 2 Diabetes, and

Sedentary Lifestyle

MILAN, April 24 /PRNewswire/ -- Data presented at today's sessions of the 43rd Annual Meeting of the European Association for the Study of the Liver (EASL) further confirm that nonalcoholic fatty liver disease (NAFLD) and its most severe form, nonalcoholic steatohepatitis (NASH), are associated with the metabolic syndrome and pose an increased risk of cardiovascular disease.

NAFLD and NASH are significant health problems that affect millions of people worldwide, especially in Western countries. NAFLD is a fatty accumulation in the liver that does not result from excessive use of alcohol. When this condition progresses, and is associated with inflammation and liver damage, it is then called NASH, which is thought to occur in 15% to 25% of cases of NAFLD. NASH is clearly associated with the risk of developing liver cirrhosis, and its complications, including hepatocellular carcinoma, the most frequent primary tumour of the liver. NASH-related cirrhosis is an increasingly occurring indication for liver transplantation.

In turn, the metabolic syndrome is a combination of risk factors, including high blood lipids, abdominal obesity, and a tendency to diabetes. The association between NAFLD, NASH, and the metabolic syndrome is a great cause for concern because people with the metabolic syndrome are at increased risk for type 2 diabetes and cardiovascular disease, including heart attack and stroke.

According to Dr. Fabio Marra, Associate Professor of Medicine at the University of Florence, "When I see a patient with a fatty liver, I have to consider all the other risk factors for cardiovascular diseases and try to intervene aggressively to limit the effects of those other factors, because accumulating data indicate that the fatty liver may be itself an additional risk factor."

The precise prevalence of NAFLD and NASH within individual countries is elusive. Large scale epidemiological studies are still needed, and definitive laboratory tests to identify patients with NASH are unavailable. At present, a biopsy of the liver is the only accepted diagnostic method. Despite these limitations, the best current estimates suggest that in the general population NAFLD can be found in one-fourth to one-third of adults in Western countries. One U.S. study of children who died as a result of accidents found that 13% had NAFLD.

While a number of risk factors have been identified, the foregoing percentages rise most dramatically among people who are obese. For example, studies have found NAFLD in 84% to 96% of patients undergoing bariatric surgery. For these reasons, NAFLD and NASH are seen to be increasing as poor dietary habits and sedentary lifestyles become more widespread.

Although NAFLD and NASH have not to date been included as components of the metabolic syndrome, increasingly the onset of NAFLD is being viewed by experts as an early event in the development of insulin resistance and therefore as an indicator or predictor of future metabolic syndrome.

Among key unanswered questions: Why do some people with NAFLD live out their lives unaffected by their condition of having a fatty liver, while others go on to develop NASH and cirrhosis, or diabetes and/or cardiovascular disease?

At present, there are no specific therapies for NASH. Among the chief recommendations offered to patients are to lose weight gradually (particularly if one is obese) and to increase physical activity, to eat a healthy diet, and to avoid alcohol.

About EASL

The European Association for the Study of the Liver (EASL) aims to promote investigation into liver disease and improve the treatments that currently exist for these conditions. The association, through its annual meetings, seeks to inform and educate both the scientific community as well as society in general about the increasing occurrence of liver diseases along with the importance of understanding these conditions in order to treat and prevent them. Since its creation in 1966, the EASL congress has been hosted in 20 different European countries. Currently the association has over 1400 members and the annual congress attracts over 6000 delegates from over 65 countries each year.


'/>"/>
SOURCE EASL - European Association for the Study of the Liver
Copyright©2008 PR Newswire.
All rights reserved

Related medicine technology :

1. Infant Formula Manufacturers Again under Ethical Cloud: Marketing Gimmick Linked to Serious Illnesses
2. Steps Toward Stopping Autoimmune Disease: International Consortium Identifies Genes Linked to Lupus
3. Study Results Reveal alli(R) Patient Satisfaction Linked to Weight Loss Achieved; Not Treatment Effects
4. Schiffrin Barroway Topaz & Kessler, LLP and Janet Jenner & Suggs, LLC Comment on Conagra Advisory Regarding Pot Pies Linked to Salmonella Outbreak
5. Joslin Study Identifies Key Factor That Links Metabolic Syndrome; Finding May Help Millions at High Risk of Cardiovascular Disease
6. The Heart, Diabetes, And Weight Loss Centers of New York Introduce the New Science of Metabolic Diagnosis and Weight Management
7. Sarasotas Roskamp Institute Releases Study Defining a Mechanism for Development of Obesity and the Metabolic Syndrome, Forerunners of Type 2 Diabetes
8. Data Presented at the American Academy of Neurology Show XP13512/GSK1838262 Significantly Improved Symptoms of Moderate-to-Severe Primary Restless Legs Syndrome
9. DSMB Supports Continuation of Anthera Phase II Impacts Trial for the Prevention of Acute Chest Syndrome in Patients With Sickle Cell Disease
10. Filter Fails to Improve PCI Outcomes in Acute Coronary Syndromes
11. Recent Data Study Suggests Cortisol Could Help Alleviate Suffering for Those With Chronic Fatigue Syndrome and Fibromyalgia
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/10/2016)... 2016  Visage Imaging Inc. ("Visage"), a wholly ... announced that the American College of Radiology (ACR) ... the Visage 7 Enterprise Imaging Platform as the ... Imaging SIMulation (SIM). SIM is the assessment component ... a multi-faceted and fully-integrated online assessment, education and ...
(Date:2/10/2016)... Jersey and OR AKIVA, Israel ... Regentis Biomaterials Ltd., a leader in the ... Series D investment round on February 5, 2016. The ... Group ("Haisco"), a leading Chinese pharmaceutical manufacturer, and ... SCP Vitalife Partners, Generali Financial Holdings and both the ...
(Date:2/10/2016)... , Feb. 10, 2016  Silicon Biosystems ... and products that help uncover the biological complexities ... Biosciences Inc., a developer of innovative technologies for ... co-marketing partnership aimed at enabling translational researchers to ... a couple hundred tumor and normal cells in ...
Breaking Medicine Technology:
(Date:2/10/2016)... ... February 10, 2016 , ... The recreational use of marijuana has been legal ... face a lot of restrictions as to where they can smoke pot. , ... and that cannabis “may not be consumed openly or publicly.” , Given the momentum ...
(Date:2/10/2016)... Tennessee (PRWEB) , ... February 09, 2016 , ... A ... reins for Summer 2016. FHU President Joe Wiley made the announcement Monday night, Feb. ... Brad Montague, a 2003 graduate of FHU and the creator of GO! Camp, has ...
(Date:2/10/2016)... ... February 09, 2016 , ... Ross A. Clevens, MD, ... to welcome a new addition to their growing practice. Beginning this month, Teresa ... nurse practitioner performing cosmetic procedures including injectables, fillers and laser treatments. ...
(Date:2/10/2016)... ... 09, 2016 , ... Traumatic Brian Injury is often in ... one of many possible sources: sports, car accidents, falls, work accidents, combat and ... Rehab Solutions for the Complexities of Concussions is designed for physical and ...
(Date:2/9/2016)... ... February 09, 2016 , ... Steven Douglas Associates is a sponsor of the ... upscale fundraiser held in South Florida. The Inaugural What’s Your Taste event will have ... event will be held in a new, more causal format at the Fort Lauderdale ...
Breaking Medicine News(10 mins):