Navigation Links
Mutant Genes in High-Risk Childhood Leukemias Identified
Date:5/19/2009

Willman, M.D., director and CEO of the University of New Mexico Cancer Research and Treatment Center and a co-senior author of the study. "A patient may have multiple different genetic lesions that target different cellular pathways to induce leukemia. Thus, it is very important to develop new therapies that target these specific mutations, and our discovery of JAK as target now allows us to begin to develop clinical trials with JAK inhibitors for children and adults with this form of disease."

In further studies, the researchers plan to identify mutations in kinase genes and other enzymes that underlie high-risk ALL, as well as explore how these abnormalities might work together to drive the cancers.

The discovery that mutations in JAK underlie some cases of high-risk ALL is enough to warrant clinical trials of inhibitory drugs to treat such cancers.

"JAK-inhibiting drugs are now moving into clinical trials for treatment of such adult myeloproliferative diseases as polycthemia vera, essential thrombocytosis and primary myelofibrosis," Downing said. "We expect that there will soon be initial clinical studies to assess the safety and effectiveness of these drugs in children with relapsed ALL in which JAK mutations have been identified within their leukemic cells."

Such studies would be coordinated by the COG, an international clinical trial cooperative group supported by the NCI.

Other authors of the paper are Racquel Collins-Underwood, Letha A. Phillips, Xiaoping Su, Wei Liu and Brenda Schulman (St. Jude); Sarah Tasian and Mignon Loh (University of California San Francisco); Meenakshi Devidas (Children's Oncology Group); Susan Atlas, I-Ming Chen and Richard C. Harvey (University of New Mexico Cancer Research and Treatment Center, Albuquerque); Robert J. Clifford, Daniela Gerhard, Malcolm Smith and Jinghui Zhang (National Cancer Institute); William C
'/>"/>

SOURCE St. Jude Children's Research Hospital
Copyright©2009 PR Newswire.
All rights reserved

Page: 1 2 3 4 5

Related medicine technology :

1. National Jewish, Brigham and Womens Awarded $37 Million to Identify Genes and Other Risk Factors that Influence the Development of COPD
2. KineMed Presents Preclinical Data for Investigational Agent Demonstrating Neurogenesis and Confirming Improvements in Behavioral Model
3. Intradigm Study Shows Ability of siRNAs Systemically Delivered With TargeTran(TM) System to Suppress Tumor-Induced Angiogenesis in Mice
4. Interim Analysis Supports Continuation of Cell Genesys VITAL-1 Phase 3 Clinical Trial of GVAX Immunotherapy for Prostate Cancer
5. Steps Toward Stopping Autoimmune Disease: International Consortium Identifies Genes Linked to Lupus
6. Genomic Health Announces Identification of Genes Associated With Colon Cancer Recurrence Across Multiple Studies
7. ADVENTRX to Present ANX-201 Preclinical Data at Keystone Symposia HIV Pathogenesis Conference
8. deCODE Launches a DNA-Based Test for Assessing Risk of Prostate Cancer on the Back of the Discovery of New Prostate Cancer Genes
9. Cell Genesys Reports Association Between Immune Response and Patient Survival in Phase 2 Trial of GVAX Immunotherapy for Prostate Cancer
10. CorMatrix(R) Announces Intramyocardial Injection of Emulsified ECM Technology(TM) Demonstrates Enhanced Angiogenesis and Improved Cardiac Function in a Preclinical Model
11. Transgenomic Establishes Collaboration With the National Cancer Institute to Investigate Mitochondrial Genome and Associated Nuclear Genes in Cancer Cell Lines
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/2/2015)... , Sept. 2, 2015  Array BioPharma Inc. ... Chief Executive Officer, Ron Squarer , will ... in Boston.  The public is welcome to participate ... Array BioPharma website.Event: Wells Fargo Securities Healthcare ConferencePresenter: ... 10, 2015Time:  , 10:20 a.m. Eastern Time Webcast: ...
(Date:9/2/2015)... , Sept. 2, 2015 ... revenue base with highly profitable specialty products ... Near-term growth potential with 11 product applications pending ... IV certifications  , Provides medium and longer ... development, including eight controlled substances , Adds ...
(Date:9/2/2015)... Sept. 2, 2015 Research and Markets ( http://www.researchandmarkets.com/research/l8z67c/pharmaceutical ... Affairs in China (Basel, Switzerland - November 26-27, 2015)" ... provide a detailed overview of the key areas of pharmaceutical ... Hong Kong , Macau and ... - All important aspects of gaining and maintaining a ...
Breaking Medicine Technology:Lannett To Acquire Kremers Urban Pharmaceuticals For $1.23 Billion 2Lannett To Acquire Kremers Urban Pharmaceuticals For $1.23 Billion 3Lannett To Acquire Kremers Urban Pharmaceuticals For $1.23 Billion 4Lannett To Acquire Kremers Urban Pharmaceuticals For $1.23 Billion 5Lannett To Acquire Kremers Urban Pharmaceuticals For $1.23 Billion 6Pharmaceutical Regulatory Affairs in China Seminar: Basel, Switzerland - November 26-27, 2015 2
... today announced the,publication of the results from a ... cruciate ligament (ACL) reconstruction,surgery. OMS103HP is an investigational ... and is designed to improve postoperative,knee function and ... return to work. The article titled "Novel Drug ...
... PHILADELPHIA, Aug. 25 Scientists have,discovered gene mutations ... the childhood cancer neuroblastoma. In addition, the researchers found,that ... forms of,non-inherited neuroblastoma, the more common form of the ... first genetic tests to families,affected by the inherited form ...
Cached Medicine Technology:Omeros Announces Publication of Clinical Results for OMS103HP in Arthroscopy: The Journal of Arthroscopic and Related Surgery 2Gene That Causes Childhood Cancer Neuroblastoma Is Found 2Gene That Causes Childhood Cancer Neuroblastoma Is Found 3Gene That Causes Childhood Cancer Neuroblastoma Is Found 4
(Date:9/3/2015)... ... September 03, 2015 , ... The new ... Report of Provo, Utah. The Clinicians Report is a leading information source to ... located throughout the U.S. Whiter Image's In-Office whitening kits were favorably validated for ...
(Date:9/3/2015)... ... ... Local filmmakers and now co-hosts of the up and coming podcast Path11 ... had great success in launching their Path11 Podcast with 23 episodes released since April ... is the well known Spiritual Catalyst and Linda Howe, leader in the field of ...
(Date:9/3/2015)... ... September 03, 2015 , ... The partnership ... customer and technical support services to promote LodonalTM in Nigeria. The distribution will ... the efficacy and safety of the product. , Managing Director, Fidson Healthcare Plc, ...
(Date:9/2/2015)... ... ... One can hardly argue against the fact that more and more people are using ... are being used as GPS, to make purchases, and yes, even to find a ... can now join the prestigious social ranks of e-dating. , Recently, Mr. Josh ...
(Date:9/2/2015)... Poulsbo, WA (PRWEB) , ... September 02, 2015 , ... ... store, open September 2015. “It was a simple decision, really,” says Chris. “We have ... shop here. They know the brands that work best for them—so we’ve given them ...
Breaking Medicine News(10 mins):Health News:Whiter Image Products Get Positive Rating From The Clinicians Report 2Health News:Path 11 Podcast Now Features over 20 Metaphysical Discussions on iTunes and Growing 2Health News:Path 11 Podcast Now Features over 20 Metaphysical Discussions on iTunes and Growing 3Health News:Fidson Partners US Firms on New Product Marketing 2Health News:Fidson Partners US Firms on New Product Marketing 3Health News:Fidson Partners US Firms on New Product Marketing 4Health News:Herpes-datingsites.com Recently Added Reviews of 5 STD Dating Apps for STD Positive Singles 2Health News:Harrison's Comfort Footwear Announces Expansion with New CHarrison Online Store 2
... are worried, as the floodplains of the Yamuna river are ... and even hotels for the 2010 Commonwealth Games. ... danger for the city's water security, they warn. ... weekend at Rajghat in New Delhi. It is being organized ...
... Taser to control agitated suspects in police custody is ... In some circles, however, the idea that using a ... controversy. ,Now, the final results of a ... of California, San Diego (UCSD) Medical Center showed no ...
... on black silk. The imagery is powerful and the prospect ... have turned to cocaine in a big way, throwing ... for instance, once hailed as a brilliant advocate, is ... naked and unconscious last Friday in a hotel room by ...
... positive effect on someones physical health? This question is ... of the latest Medical Journal of Australia. ... and spirituality in health, its relevance to Australian practitioners ... practice, and the current gaps where more research is ...
... hydropower projects being clean, a new scientific study has ... for at least 19 percent of India's global ... study, Indian dams are larger methane emitters and total ... around 33.5 million tonnes (MT) per annum, including emissions ...
... in the mouth like a popular breath-freshener could someday ... The innovative drug-delivery system was developed by Johns ... two-semester course, the seven-student team fabricated a thin film ... the child to swallow the vaccine. The dissolved medication ...
Cached Medicine News:Health News:Green Campaigners Concerned About Yamuna's Shrinking Floodplains 2Health News:Healthy Humans Not Harmed By Taser 2Health News:Australia Agonising Over the Problem of Cocaine Use by Lawyers 2Health News:Australia Agonising Over the Problem of Cocaine Use by Lawyers 3Health News:Students Devise Oral Quick-dissolve Strips for Rotavirus Vaccine 2Health News:Students Devise Oral Quick-dissolve Strips for Rotavirus Vaccine 3
The Perfecta PDA components provide the design and material choice imperative in today's cost conscious medical climate....
Cementless hip stem revisions offering optimal version setting for each patient. Compatible with modular link ceramic or cobalt chromium femoral heads with up to 4 neck lengths, or the link saddle de...
The proximally modular S-ROM Total Hip System provides custom capability at non-custom prices and is competitive with conventional porous coated systems....
The proximally modular S-ROM Total Hip System provides custom capability at non-custom prices and is competitive with conventional porous coated systems....
Medicine Products: