Navigation Links
Mutant Genes in High-Risk Childhood Leukemias Identified
Date:5/19/2009

/p>

The new study builds on the researchers' previous genetic analysis of the leukemic cells from pediatric ALL patients.

"The findings from our previous studies have hinted that some high-risk ALL cases might arise from mutations in genes that produce enzymes called kinases, which function as biological on-off switches in cells," said Charles Mullighan, M.D., Ph.D., assistant member in the St. Jude Department of Pathology and a co-first author of the study. "Such mutations would cause those kinases to be stuck in the on position, triggering the uncontrolled proliferation of white blood cells that is seen in leukemia."

Thus, the researchers began to analyze the genetic sequences of many kinases known to be components of the proliferation machinery of white blood cells. The team analyzed the leukemic cells from 187 patients with high-risk ALL. That analysis revealed mutations in about 10 percent of the cases in a family of protein kinases called JAK, whose members were also known to be mutated in other types of leukemias and related diseases.

"Further studies of these mutant JAK proteins revealed that the changes in their molecular structures could switch them on to drive the blood cell proliferation that is characteristic of ALL," said Stephen Hunger, M.D., chairman of the COG ALL committee and a co-senior author of the study. "What's more, in test tube studies, we found that drugs blocking the activation of the mutant JAK kinases prevented uncontrolled growth suggesting that drugs that target JAK proteins might be effective in this subtype of ALL."

The researchers discovered, in some high-risk ALL patients, that mutations in JAK appeared to work in concert with another mutation -- in the gene IKZF1 -- which they had earlier found to underlie such cases.

"Our studies of these leukemia subtypes indicate that leukemia is not necessarily a single-cause disease," said Cheryl
'/>"/>

SOURCE St. Jude Children's Research Hospital
Copyright©2009 PR Newswire.
All rights reserved

Page: 1 2 3 4 5

Related medicine technology :

1. National Jewish, Brigham and Womens Awarded $37 Million to Identify Genes and Other Risk Factors that Influence the Development of COPD
2. KineMed Presents Preclinical Data for Investigational Agent Demonstrating Neurogenesis and Confirming Improvements in Behavioral Model
3. Intradigm Study Shows Ability of siRNAs Systemically Delivered With TargeTran(TM) System to Suppress Tumor-Induced Angiogenesis in Mice
4. Interim Analysis Supports Continuation of Cell Genesys VITAL-1 Phase 3 Clinical Trial of GVAX Immunotherapy for Prostate Cancer
5. Steps Toward Stopping Autoimmune Disease: International Consortium Identifies Genes Linked to Lupus
6. Genomic Health Announces Identification of Genes Associated With Colon Cancer Recurrence Across Multiple Studies
7. ADVENTRX to Present ANX-201 Preclinical Data at Keystone Symposia HIV Pathogenesis Conference
8. deCODE Launches a DNA-Based Test for Assessing Risk of Prostate Cancer on the Back of the Discovery of New Prostate Cancer Genes
9. Cell Genesys Reports Association Between Immune Response and Patient Survival in Phase 2 Trial of GVAX Immunotherapy for Prostate Cancer
10. CorMatrix(R) Announces Intramyocardial Injection of Emulsified ECM Technology(TM) Demonstrates Enhanced Angiogenesis and Improved Cardiac Function in a Preclinical Model
11. Transgenomic Establishes Collaboration With the National Cancer Institute to Investigate Mitochondrial Genome and Associated Nuclear Genes in Cancer Cell Lines
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/26/2014)...  Perrigo Company plc ("Perrigo") (NYSE: PRGO ... Healthcare Products®," today announced the closing of Perrigo,s previously ... 6,809,210 ordinary shares at a public offering price of ... option to purchase up to an additional 888,157 ordinary ... Inc., as representatives of the several underwriters. ...
(Date:11/26/2014)... Nov. 26, 2014   Regulus Therapeutics Inc . ... the discovery and development of innovative medicines targeting microRNAs, ... President and CEO of Regulus, will present a company ... Healthcare Conference at the New York Palace Hotel on ... presentation will be webcast at the time of the ...
(Date:11/26/2014)... LOUIS , Nov. 26, 2014 Scott Steiger ... seen most of the world. As an engineer for the past ... a member of the military service. He,s been to six of ... Photo - http://photos.prnewswire.com/prnh/20141126/161076 Photo - ... specifically for travelers, he has a pretty good idea of what,s ...
Breaking Medicine Technology:Perrigo Company plc Announces The Closing Of Its Registered Public Offering Of Ordinary Shares 2Perrigo Company plc Announces The Closing Of Its Registered Public Offering Of Ordinary Shares 3Perrigo Company plc Announces The Closing Of Its Registered Public Offering Of Ordinary Shares 4Regulus to Present at the 26th Annual Piper Jaffray Healthcare Conference and Genetic Rx Conference 2Regulus to Present at the 26th Annual Piper Jaffray Healthcare Conference and Genetic Rx Conference 3Steiger Has Created the First Pill Case Specifically Designed For Travel 2
... National Community Pharmacists Association Executive Vice ... in response to the Florida House Judicial Committee,s passage of ... in particular an amendment that would restrict the ... III to publicly traded pharmacy chains or only those ...
... 31, 2011 OncoSec Medical Inc. (OTC BB: ONCS), a ... announced today that it has raised more than $1 million ... institutional investors. OncoSec issued 1,456,000 units at a price of ... consisted of one share of common stock and one share ...
Cached Medicine Technology:Legislation Would Deny Floridians Access to Needed Medicines from Their Trusted Independent Community Pharmacies, and Instead Favor Publicly Traded Chain Pharmacies 2OncoSec Medical Closes $1.1M Financing 2
(Date:11/27/2014)... GA (PRWEB) November 27, 2014 "The uglier, ... whole month of December is full of laughter as we ... Wilson won by making a sweater from scratch. " It ... Christmas tree, and if that weren't ridiculous enough, the Christmas ... top. , For those interested in participating this year, ...
(Date:11/27/2014)... Ethane Web Technologies, an ISO 9001: 2008 certified ... Christmas discount on PPC service. The discount will be available ... begin on 1 December 2014 and remain valid until midnight ... PPC professional working at Ethane Web Technologies says, "This is ... this big discount would make the service quite affordable for ...
(Date:11/27/2014)... November 27, 2014 Serious Buyer, Andrew ... 1969 Jimi Hendrix Tuscaloosa Memorial Coliseum concert posters. Between ... played at the University of Alabama. Jimi Hendrix started ... Hawley, “It started with Gary Weinberger who was a ... University Programs Council. The council was responsible for bringing ...
(Date:11/26/2014)... Recently, DressVe , the well-known company of wedding ... 2014 Cyber Monday Sales. Also, the company has announced ... percent off. The special offer is valid from Nov. ... for orders above $69. , Now, DressVe.com features an ... fashion accessories. The mission of the company is to ...
(Date:11/26/2014)... November 27, 2014 iFitDress.com, a well-known ... collection of sweet 16 cocktail dresses . Included ... 16 cocktail gowns. Furthermore, all of these charming outfits ... off. , The company has promised that all of ... finest materials. It is worth mentioning that all of ...
Breaking Medicine News(10 mins):Health News:Verde Pointe Dental Associates Hosts 2014 Ugly Holiday Sweater Contest 2Health News:Verde Pointe Dental Associates Hosts 2014 Ugly Holiday Sweater Contest 3Health News:Ethane Web Technologies Announces 10% Christmas Discount on PPC Service 2Health News:Serious Buyer Announces His Search For Vintage 1969 Jimi Hendrix Tuscaloosa Memorial Coliseum Concert Posters 2Health News:DressVe.com: Best 2014 Special Monday Sales Online 2Health News:iFitDress.com: Trendy Sweet 16 Cocktail Dresses Unveiled 2
... ... consumers with the latest information and resources on over 150 natural health and alternative ... ... leader in natural health and alternative medicine, has launched WellnessTweets.com , a Twitter ...
... Eyewear, exclusive global distributor for Cantor & Nissel optical products outside Europe , has named Feintuch Communications, Inc. ( www.feintuchcommunications.com ) as agency of record. , ... , ... ... ...
... ANN ARBOR, Mich. A potent new inhibitor of HIV, ... to prevent sexual transmission of HIV, according to a University ... Scientists have an emerging interest in lectins, naturally occurring chemicals ... of reaction that leads to a variety of infections. ...
... , ROCHESTER, N.Y. , March 15 Bausch + Lomb has named Fred Hassan as chairman of the Board of Directors and has named Brent Saunders ... ... ... ...
... Third-Generation, Family-Owned Company Joins March for Babies (R) , ... , , ... ... WHITE PLAINS, ...
... ... the nation to offer Ultherapy™ , ... Grand Rapids, MI (PRWEB) March 15, 2010 -- With the increasing demand for non-surgical ... great news to consumers, especially those in this community, home to one of the first ...
Cached Medicine News:Health News:altMD Launches Health & Wellness Twitter Application WellnessTweets.com 2Health News:Maxine Morgan Eyewear Chooses Feintuch Communications for Integrated Public Relations and Marketing Campaign 2Health News:Maxine Morgan Eyewear Chooses Feintuch Communications for Integrated Public Relations and Marketing Campaign 3Health News:Maxine Morgan Eyewear Chooses Feintuch Communications for Integrated Public Relations and Marketing Campaign 4Health News:University of Michigan scientists identify chemical in bananas as potent inhibitor of HIV infection 2Health News:Bausch + Lomb Names Fred Hassan as Chairman, Brent Saunders as Chief Executive Officer 2Health News:Bausch + Lomb Names Fred Hassan as Chairman, Brent Saunders as Chief Executive Officer 3Health News:Bausch + Lomb Names Fred Hassan as Chairman, Brent Saunders as Chief Executive Officer 4Health News:Mission Pharmacal and March of Dimes Share Commitment to Healthy Babies 2Health News:Mission Pharmacal and March of Dimes Share Commitment to Healthy Babies 3Health News:Mission Pharmacal and March of Dimes Share Commitment to Healthy Babies 4Health News:Medical Ultrasound Now Used in New, Non-surgical Cosmetic Procedure 2
Standard reading test. "Children should be..."...
Printed with large 20/200 E on one side and a series of five 20/20 tumbling Es on the other- calibrated to a 20 ft. distance. May be used to test and train peripheral awareness....
The PowerLab/4ST is a high-performance recording unit with built-in amplifiers and is suitable for physiology teaching. It has been designed to cover the broad experimental requirements in life scien...
Three Figure Worth Type Test, this test is used for determining diplopia, suppression or fusion in children. Sturdy chrome flashlight comes with red/green glasses. Requires 3 D batteries which are no...
Medicine Products: