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MultiCell Technologies and Genisphere Evaluate Targeted Delivery of MCT-485, a Noncoding miRNA for the Treatment of Cancer
Date:8/6/2013

WOONSOCKET, R.I., Aug. 6, 2013 /PRNewswire/ -- MultiCell Technologies, Inc. (OTC Bulletin Board: MCET) and Genisphere LLC will collaborate on the development of targeted MCT-485 nanoparticle therapeutics for the treatment of liver cancer.  MCT-485 is a noncoding double stranded micro RNA (miRNA) which has demonstrated oncolytic and immune stimulating activity in in vitro models of hepatocellular carcinoma.

Hepatocellular carcinoma is the most common form of primary liver cancer, and is a leading cause of cancer death worldwide.  Hepatocellular carcinoma remains an unmet medical need, and today's approaches for treatment are of limited efficacy.   Current standard-of-care in certain clinical stages of hepatocellular carcinoma is based on trans catheter arterial chemoembolization utilizing suspension of doxorubicin in lipiodol or drug eluting beads, with or without other approaches.  While such approaches have shown an improvement in clinical outlook over symptomatic treatment, novel compounds, drug delivery methods, and treatments are needed to ensure a more durable management of tumor progression, and delay or prevention of tumor relapse.  MCT-485, possessing both oncolytic and immune activating properties, could be superior to doxorubicin, cisplatin and other currently marketed chemotherapies by providing a more robust activation of immunity, and a more global and longer lasting anti-tumor effect.

MultiCell and Genisphere will investigate the use of Genisphere's patented 3DNA® Dendrimer nanoparticle drug delivery technology to enable the targeted delivery of MCT-485 to the tumor and away from normal tissues.  Formulations that meet several criteria: (1) are safe enough to allow parenteral administration by infusion (venous, arterial) or topical administration (intra-tumoral); (2) achieve an
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SOURCE MultiCell Technologies, Inc.
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