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MultiCell Technologies Files U.S. Patent Application for Targeted Delivery of Noncoding Micro RNAs for the Treatment of Liver Cancer
Date:5/16/2013

WOONSOCKET, R.I., May 16, 2013 /PRNewswire/ -- MultiCell Technologies, Inc. (OTC Bulletin Board: MCET.OB) is pleased to announce the filing of a U.S. patent application concerning methods and formulations to achieve targeted tumor cell death.  MCT-485 is a noncoding double stranded micro RNA (miRNA) which has demonstrated oncolytic and immune stimulating activity in in vitro models of hepatocellular carcinoma.

Hepatocellular carcinoma is the most common form of primary liver cancer, and is a leading cause of cancer death.  Hepatocellular carcinoma remains an unmet medical need, and today's approaches for treatment are of limited efficacy.  A potential role for noncoding double stranded miRNAs such as MCT-485 in the control of tumors has recently emerged in a variety of models with recognition of their ability to stimulate an immune response or directly affect cell death.

Current standard-of-care in certain clinical stages of hepatocellular carcinoma is based on trans catheter arterial chemoembolization (TACE) utilizing suspension of doxorubicin in lipiodol or drug eluting beads, with or without other approaches.  While such approaches have shown an improvement of the clinical outlook over symptomatic treatment, novel compounds and treatments are needed to ensure a more durable management of tumor and delay or prevention of tumor relapse.  Compounds such as MCT-485 possessing both oncolytic and immune activating properties could be superior to doxorubicin, cisplatin and other chemotherapies employed in TACE, as robust activation of immunity in the context of antigen release associated with cell death could have a more global and longer lasting anti-tumor effect.

The key need addressed by this invention is directing the powerful biological effect of miRNAs such as MCT-485 towards the tumor and away from normal tissues.  Formulations that meet several criteria: (1) are safe enough to
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SOURCE MultiCell Technologies, Inc.
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