Navigation Links
Multi-therapy Drugs: Opportunities for Generics & Biosimilars
Date:11/2/2011

topic of discussion. In the meantime, companies are hedging their bets and conducting comparative studies of their biosimilar MAbs in more than one indication.

About the Author

The report has been researched and written by Espicom Senior Analyst, Karen Holmes. Karen has over 15 years pharmaceutical and healthcare market analysis experience. Her recent studies include:

Hospital Injectable Drugs: Future Prospects for Generics and Biosimilars

Emerging Opportunities in Inhalation and Nasal Spray Generic Drugs

Ophthalmology Drug Futures.

Contents

FOREWORD .... 1

EXECUTIVE SUMMARY .. 3

OVERVIEW ...... 5

Lifecycle Development and New Indications ....... 5

Realising Additional Sales Potential .. 7

Rituximab: Multiple Indications from Oncology to Immunology ..... 8

Sildenafil: One Active Ingredient, Two Distinctly Branded Indications ... 9

Generic and Biosimilar Opportunities ..... 9

Biosimilar Approval for Multiple Indications: Extrapolation or Additional Trials? ..... 10

US Patent Expiries ..... 11

PRODUCT ANALYSIS ... 12

ANTI-METABOLITES .... 13

Alimta (pemetrexed) ... 13

Mode of Action ... 13

Approvals ..... 13

Lifecycle Development ... 14

Competition within the Marketplace . 14

Patents .. 15

Generic Company Activity ..... 15

Market Outlook .. 15

Xeloda (capecitabine) . 17

Mode of Action ... 17

Approvals ..... 17

Lifecycle Development ... 19

Competition within the Marketplace . 19

Colorectal Cancer ...19

Breast Cancer ..19

Gastric Cancer .20

Patents .. 20

Generic Company Activity ..... 20

Market Outlook .. 20

MONOCLONAL ANTIBODIES ... 22

Rituxan/MabThera (rituximab) 22

Mode of Action ... 22

Approvals ..... 22

Lifecycle Development ... 24

Competition within t
'/>"/>

SOURCE S .... 104
Copyright©2010 PR Newswire.
All rights reserved

Page: 1 2 3 4 5 6 7

Related medicine technology :

1. Generic Drugs: The Global Market--Focus on Europe
2. Generic Drugs: The Global Market--Focus on Asia
3. Generic Drugs: The Global Market
4. Generic Drugs: The Global Market: Focus on the Americas
5. Reportlinker Adds Leading Anti-Cancer Drugs: World Market Prospects 2011-2021
6. FDA CONSUMER HEALTH INFORMATION - Combating Misuse and Abuse of Prescription Drugs: Q&A with Michael Klein, Ph.D.
7. Reportlinker Adds Ophthalmic Therapeutic Drugs: Technologies and Global Markets
8. Reportlinker Adds Antifungal Drugs: Technologies and Global Markets
9. The Future of GPCRs in Drug Discovery: Novel technologies, leading companies, and opportunities for target expansion
10. Pharmaceutical Industry Leaders to Tackle Groundbreaking Challenges, Opportunities for Pharma & Biotech at Elite Event
11. Early Stage Drug Safety Strategies and Risk Management: Maximizing opportunities towards achieving clinical success
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/24/2014)... LONDON , December 24, 2014 ... grow at an average rate of 8.1%. The US ... Hip, knee and spine surgeries are the common orthopedic ... they have a lower penetration. Increased number of product ... composites. Non-metallic orthopedic devices have gained popularity in the ...
(Date:12/24/2014)... DALLAS , December 24, 2014 /PRNewswire/ ... Research Report on Global Disposable Syringe Industry ... to its online business intelligence library. ... Global Disposable Syringe Industry is a professional ... Syringe market.  For overview analysis, the report ...
(Date:12/24/2014)... China , Dec. 23, 2014 ... pharmaceutical company that specializes in patented biopharmaceutical, modernized ... pharmaceutical ingredients (API) today announced that the Company ... its Good Manufacturing Practice (GMP) certificate of TPI,s ... Drug Administration,s (CFDA). The public notice period is ...
Breaking Medicine Technology:Use of Composites in Orthopedic Industry to Reach $596 Million by 2020 2Use of Composites in Orthopedic Industry to Reach $596 Million by 2020 3World Disposable Syringe Market 2014 Report: China and Regional Analysis 2World Disposable Syringe Market 2014 Report: China and Regional Analysis 3World Disposable Syringe Market 2014 Report: China and Regional Analysis 4World Disposable Syringe Market 2014 Report: China and Regional Analysis 5TPI QLF Achieved Public Notice Status of GMP Certification 2TPI QLF Achieved Public Notice Status of GMP Certification 3
... options and research directions , , WASHINGTON, June ... therapeutic option for many patients with interstitial cystitis (IC). IC ... 8 million women and 1.5 million men in the United ... noticed a correlation between allergies and IC. Recently, a urologist ...
... Families of Spinal Muscular Atrophy has just released details ... funded therapeutic pipeline. , , Families of SMA ... Quinazolines to boost gene expression; 2) Tetracyclines at Paratek ... replacement program at California Stem Cell and UCI. ...
Cached Medicine Technology:Urologist and Allergist Explore Link Between Allergies and Interstitial Cystitis 2Urologist and Allergist Explore Link Between Allergies and Interstitial Cystitis 3Urologist and Allergist Explore Link Between Allergies and Interstitial Cystitis 4Families of Spinal Muscular Atrophy Announces Latest Developments on Three SMA Drug Discovery Programs 2Families of Spinal Muscular Atrophy Announces Latest Developments on Three SMA Drug Discovery Programs 3
(Date:12/25/2014)... 2014 Helen Harris’ RP (Retinitis Pigmentosa) ... California after an 8 year battle with breast cancer. ... evening in her home in Woodland Hills California after ... , As the founder and volunteer ... pioneered and championed many of today's greatest breakthroughs in ...
(Date:12/25/2014)... Recently, LunaDress.co.uk has updated its blog to provide professional shopping ... of the models at LunaDress.co.uk come with big discounts, up to ... veil can turn out to be a most exciting memory and ... always bring surprise to a wedding. On the updated fashion blog, ... veils for a big day . , Going out with friends ...
(Date:12/25/2014)... Dec. 25, 2014 (HealthDay News) -- The risk of ... holidays, so you need to be extra cautious, an ... we see a significant increase in patients coming in ... the Suffolk County Volunteer Firefighters Burn Center of Stony ... should be full of joy, but if not careful, ...
(Date:12/25/2014)... 2014 (HealthDay News) -- Among early stage breast cancer ... half of one percent will eventually develop leukemia as ... The finding comes from a review of more ... 2007, and it suggests that the risk for developing ... had previously thought. "The frequency of bone marrow ...
(Date:12/25/2014)... AngelWeddingDress.com tries its best to translate ... Today, the business has introduced its new collection of ... promotion. , The new prom outfits are guaranteed to ... lover. They are specially designed for 2015. Anyone who ... should visit its website before Jan. 26, 2015, the ...
Breaking Medicine News(10 mins):Health News:RP International founder, Helen Harris Dies on Christmas Eve Just Hours Before Her Holiday Television Broadcast to Raise Funds to Cure Blindness was Broadcasted Nationally 2Health News:RP International founder, Helen Harris Dies on Christmas Eve Just Hours Before Her Holiday Television Broadcast to Raise Funds to Cure Blindness was Broadcasted Nationally 3Health News:RP International founder, Helen Harris Dies on Christmas Eve Just Hours Before Her Holiday Television Broadcast to Raise Funds to Cure Blindness was Broadcasted Nationally 4Health News:LunaDress Provides Professional Tips On Shopping Wedding And Prom Dresses 2Health News:Don't Let Burns Mar Your Holidays 2Health News:Breast Cancer Chemo Tied to Small But Significant Leukemia Risk 2Health News:Breast Cancer Chemo Tied to Small But Significant Leukemia Risk 3Health News:Angelweddingdress 2015 Prom Dresses Online Now 2
... the community-based model of directly observed therapy (DOT) ... improves patient survival. This is according to researchers ... Health, in collaboration with colleagues at University of ... randomized controlled trial of patient-nominated treatment-supporters providing partial ...
... CORVALLIS, Ore. Researchers have discovered a new strain ... and effectively help degrade polycyclic aromatic hydrocarbons, or PAHs ... harmful aspects of oil spills. Because of its ... considerable value in the long-term cleanup of the massive ...
... half of patients hospitalized with bipolar disorder may suffer ... with the psychiatric condition the more likely they are ... Michigan State University study. The study, led by ... bipolar disorder, a condition sometimes called manic-depressive disorder and ...
... belong to a youth club, they gain a stronger sense ... University study has revealed. The study suggests that even ... keeping children out of trouble. "The more kids participate ... Dawn Anderson-Butcher, an associate professor of social work at Ohio ...
... INDIANAPOLIS The Indiana Network for Patient Care (INPC), ... the United States, is expanding to include post-acute care ... to a growing number of individuals who often have ... facilities, part of Golden Living, the leading provider of ...
... -- The combination of decitabine and carboplatin appears to improve ... an upcoming issue of the journal Cancer (online ... participated in a phase I clinical trial had no disease ... resolution of tumor tissue for a period of time. ...
Cached Medicine News:Health News:Directly observed HIV treatment by patient-nominated treatment supporter improves survival 2Health News:New strain of bacteria discovered that could aid in oil spill, other environmental cleanup 2Health News:New strain of bacteria discovered that could aid in oil spill, other environmental cleanup 3Health News:MSU researcher identifies links between hypertension, bipolar disorders 2Health News:Youth clubs strengthen kids' self image to keep them out of trouble 2Health News:Youth clubs strengthen kids' self image to keep them out of trouble 3Health News:Improving care for older adults 2Health News:Improving care for older adults 3Health News:Late-stage ovarian cancer shows promise in 2-drug phase I trial 2Health News:Late-stage ovarian cancer shows promise in 2-drug phase I trial 3
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
Medicine Products: