Navigation Links
Multi-centre Phase II Trial Reports Safety and Clinical Benefits of Radioactive Microspheres in Patients with Colorectal Cancer Liver Metastases who have Failed Chemotherapy
Date:8/19/2010

p> "These results reveal that radioembolisation using SIR-Spheres is a promising therapy for patients with colorectal cancer liver metastases who have failed chemotherapy," said Prof. Maurizio Cosimelli, Professor of Surgery at the Regina Elena National Cancer Institute in Rome, and co-ordinator of the study. "The prolonged 12.6-month median survival and encouraging tumour response reported in the SITILO study compares favourably with the clinical trial results of second- or third-line chemotherapy, even though three-quarters of our patients had previously received at least four different combinations of chemotherapy drugs and therefore had a poor prognosis with no other treatment options available."

"At a minimum, patients with liver-only or liver-dominant colorectal cancer who are failing chemotherapy and who remain fit should be considered for radioembolisation using SIR-Spheres," said Prof. Cosimelli. "However, SITILO will be conducting a multi-centre randomised trial using SIR-Spheres in combination with chemotherapy at an earlier line of treatment since we believe that this may further improve the prognosis for patients with colorectal liver metastases. Above all, it will be possible to clarify the potential of SIRT together with chemotherapy to increase the rate of surgical resections in patients that were previously unresectable."

Patients in the SITILO study had to have liver metastases from colorectal cancer that could not be removed by surgery and which had progressed despite modern chemotherapy regimens containing oxaliplatin and irinotecan. The presence of metastases outside the liver did not exclude the patients from treatment as long as these were limited in number, size and in the same organ. All patients were heavily pre-treated, having received at least 3 previous chemotherapy regimens: 24% had received 3 different lines or courses of chemotherapy, 50% had received 4 lines and 26% had received 5 lines.

The SITILO study used
'/>"/>

SOURCE Sirtex
Copyright©2010 PR Newswire.
All rights reserved

Page: 1 2 3 4 5 6 7 8 9

Related medicine technology :

1. Multi-Centre European Clinical Trial Shows Advanced Dysplasia and Early Cancer of Esophagus Cured With Combined Endoscopic Resection and Radiofrequency Ablation With HALO Ablation System
2. Dendreon Announces Publication of Phase 1 Study Highlighting Immunologic and Clinical Activity of Lapuleucel-T (Neuvenge(R)) in Advanced Breast Cancer Patients
3. Thomson Scientific Publishes The Ones to Watch - A Quarterly Review of Phase Changes in the Pharmaceutical Pipeline
4. Progen Engages Leading CRO to Assist with Phase 3 Trial of PI-88
5. The Multiple Myeloma Research Consortium (MMRC) and Proteolix Initiate Phase 2 Clinical Trial Investigating Carfilzomib for the Treatment of Multiple Myeloma
6. Vion Pharmaceuticals Completes Accrual of 85 Patients to its Pivotal Phase II Trial of Cloretazine(R) (VNP40101M) in Elderly AML
7. Multiple Myeloma Research Consortium (MMRC) Partners with Novartis to Advance Phase II Study of Deacetylase Inhibitor
8. Positive Kuvan(TM) Pivotal Phase 3 Trial Results Published in The Lancet
9. Potential Safety Issue Identified in Ongoing Phase 2 Clinical Study of HCV-796
10. TaiGen Biotechnology Successfully Completes Patient Recruitment for Phase II Trial of Nemonoxacin for Treatment of Adult Community Acquired Pneumonia (CAP)
11. DOV Pharmaceutical, Inc. Announces Successful Phase Ib Results for DOV 21,947
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/30/2014)... -- , Extensively hydrolyzed milk formula with LGG ... Cow milk protein allergy (CMPA) is the leading cause of food ... has been managed by eliminating milk proteins from a ... is possible to help build of oral tolerance to ... the first year of life by using an extensively ...
(Date:10/30/2014)... , Oct. 29, 2014 nebulizer is a ... (asthma, COPD and cystic fibrosis) that converts liquid medication ... reach into the lungs of a patient when inhaled ... nebulizers market is dominated by various devices powered by ... prevalence of asthma, COPD and cystic fibrosis and growing ...
(Date:10/30/2014)... LOS ANGELES , Oct. 29, 2014 /PRNewswire/ ... pharmaceutical company devoted to bringing new products to ... 2015. ViaDerma has developed an innovative, ... for rapid mass transfer of pharmaceutical active ingredients ... to provide immediate localized therapy. The transdermal delivery ...
Breaking Medicine Technology:Experts Present Latest Research at Allergy Day 2Experts Present Latest Research at Allergy Day 3Nebulizers Market (Pneumatic Nebulizers, Ultrasonic Nebulizers and Mesh Nebulizers) - Global Industry Analysis, Size, Share, Growth, Trends and Forecast, 2013 - 2019 2Nebulizers Market (Pneumatic Nebulizers, Ultrasonic Nebulizers and Mesh Nebulizers) - Global Industry Analysis, Size, Share, Growth, Trends and Forecast, 2013 - 2019 3ViaDerma, Inc. Announces Plans to Pursue Out-Licensing Partnerships in 2015 2ViaDerma, Inc. Announces Plans to Pursue Out-Licensing Partnerships in 2015 3
... at American College of Rheumatology Annual Congress -, ... BMY ) today announced the results of ... that showed ORENCIA(R) (abatacept) improved daily,activity participation, such ... and sleep quality in adult rheumatoid arthritis,(RA) patients ...
... Ophthalmology Annual Meeting Describes ... in Treatment of Endothelial Disease, NEW ORLEANS, Nov. ... Academy of Ophthalmology,s Annual Meeting, Massimo Busin,MD, department head ... Italy, described a technique that significantly improved,results in patients ...
Cached Medicine Technology:Post-Hoc Data Show Daily Activity Participation, Independence and Sleep Quality Improved in Adults with Moderate to Severe Rheumatoid Arthritis After Treatment with ORENCIA(R) (Abatacept) 2Post-Hoc Data Show Daily Activity Participation, Independence and Sleep Quality Improved in Adults with Moderate to Severe Rheumatoid Arthritis After Treatment with ORENCIA(R) (Abatacept) 3Post-Hoc Data Show Daily Activity Participation, Independence and Sleep Quality Improved in Adults with Moderate to Severe Rheumatoid Arthritis After Treatment with ORENCIA(R) (Abatacept) 4Post-Hoc Data Show Daily Activity Participation, Independence and Sleep Quality Improved in Adults with Moderate to Severe Rheumatoid Arthritis After Treatment with ORENCIA(R) (Abatacept) 5Post-Hoc Data Show Daily Activity Participation, Independence and Sleep Quality Improved in Adults with Moderate to Severe Rheumatoid Arthritis After Treatment with ORENCIA(R) (Abatacept) 6Post-Hoc Data Show Daily Activity Participation, Independence and Sleep Quality Improved in Adults with Moderate to Severe Rheumatoid Arthritis After Treatment with ORENCIA(R) (Abatacept) 7Post-Hoc Data Show Daily Activity Participation, Independence and Sleep Quality Improved in Adults with Moderate to Severe Rheumatoid Arthritis After Treatment with ORENCIA(R) (Abatacept) 8Post-Hoc Data Show Daily Activity Participation, Independence and Sleep Quality Improved in Adults with Moderate to Severe Rheumatoid Arthritis After Treatment with ORENCIA(R) (Abatacept) 9Improved Cornea Surgery Technique Provides Enhanced Transplant Success 2
(Date:10/30/2014)... 2014 Don Allred Insurance, a leading ... plans for North Carolina residents, is excited to announce ... Holly Hill Mall. The new branch has been up ... customers through all facets of the insurance selection process ... spokesman Scott Allred couldn’t be happier with the timing ...
(Date:10/30/2014)... 2014 PreDiabetes Centers , the ... shoppers with a supply of sugardown®, a chewable ... post-meal blood sugar spikes. Learning how to control blood ... part of a diabetes prevention plan. , Shoppers who ... complimentary tube of sugardown. The offer expires November 30. ...
(Date:10/30/2014)... Reinberg HealthDay Reporter , WEDNESDAY, ... men with prostate cancer who also have certain heart problems ... a new study suggests. , , The therapy in question is ... to reduce levels of male hormones to prevent the growth ... current research, this hormone therapy was linked to triple the ...
(Date:10/30/2014)... Canada (PRWEB) October 30, 2014 Home ... area’s leading provider of non-medical, in-home senior care, is ... to increased brain health. , The study, performed by ... ages of 60 and 78 over a week-long period ... opposed to daily physical activity. By examining the structural ...
(Date:10/30/2014)... California (PRWEB) October 30, 2014 Global ... by 2020, according to a new study by Grand ... with surging demand for sugar and fat free products ... augment the demand for prebiotics over the forecast period. ... http://www.grandviewresearch.com/industry-analysis/prebiotics-market , Food & beverage was the largest ...
Breaking Medicine News(10 mins):Health News:Allred Insurance Satellite Office Grand Opening 2Health News:PreDiabetes Treatment Company Offers PreD Store Shoppers Supplements to Support Healthy Blood Sugar 2Health News:Hormone Therapy May Up Heart-Related Deaths in Some Prostate Cancer Patients 2Health News:Hormone Therapy May Up Heart-Related Deaths in Some Prostate Cancer Patients 3Health News:Home Care Assistance – Halton/Peel Region, a Top Provider of In-Home Care, Responds to Study Linking Exercise to Healthier Senior Brains 2Health News:Home Care Assistance – Halton/Peel Region, a Top Provider of In-Home Care, Responds to Study Linking Exercise to Healthier Senior Brains 3Health News:Prebiotics Market Is Expected To Grow At A CAGR Of 9.3% From 2014 To 2020: Grand View Research, Inc. 2Health News:Prebiotics Market Is Expected To Grow At A CAGR Of 9.3% From 2014 To 2020: Grand View Research, Inc. 3Health News:Prebiotics Market Is Expected To Grow At A CAGR Of 9.3% From 2014 To 2020: Grand View Research, Inc. 4Health News:Prebiotics Market Is Expected To Grow At A CAGR Of 9.3% From 2014 To 2020: Grand View Research, Inc. 5
... Applying a vapor rub is effective for treating children ... children with cold symptoms, according to Penn State College ... most common acute illnesses in the world," said Ian ... health sciences. "Symptoms caused by these infections are disruptive ...
... Lupus puts children at higher risk for coronary artery ... doesn,t provide enough benefit to warrant their regular use ... of pediatric lupus patients to date. Lupus is ... damage. Children with lupus show early signs of atherosclerosis ...
... Approximately 600,000 hysterectomies are performed in the United ... pelvis. More than two-thirds are performed through an ... online today in The Journal of Minimally ... society of over 5,000 gynecologic surgeons, advocates the ...
... News) -- Impaired understanding of how social contracts work and ... cheat and take risks even though they know right from ... percent of people in the United States are psychopaths, they ... their tendency for impulsive, destructive and harmful behavior, noted the ...
... Nov. 5 (HealthDay News) -- Over the past 10 years, ... as lupus nephritis have vastly improved, according to a new ... is a complication that can occur in individuals with the ... better quality of life, without many of the harsh treatment ...
... THURSDAY, Nov. 4 (HealthDay News) -- Annual screening for lung ... current or former heavy smokers by 20 percent, a major ... Americans who fall ill from lung cancer -- the nation,s ... could be significant, experts noted. And, unexpectedly, annual CT ...
Cached Medicine News:Health News:Vapor rub relieves cold symptoms for children, helps them sleep better 2Health News:Vapor rub relieves cold symptoms for children, helps them sleep better 3Health News:Statins don't prove useful for general pediatric lupus population 2Health News:Most hysterectomies should be performed vaginally or laparoscopically 2Health News:Psychopaths May Lack Understanding of Social Contracts: Study 2Health News:Lupus Kidney Disorder Treatment Improved Over Decade: Review 2Health News:CT Scans Seem to Lower Lung Cancer Death Rates 2Health News:CT Scans Seem to Lower Lung Cancer Death Rates 3Health News:CT Scans Seem to Lower Lung Cancer Death Rates 4
Provides stable positioning of a patient during hip surgery. Multi-adjustment arms allow the positioner to be adjusted to fit all sizes of patients. Especially helpful with large patients where reach...
Interphlex Flexible Stablization Rods offer correction of Hammer Toes with a High level of Flexibility while maintaining correct toe length and shape....
The Continuous Wave II Arthroscopy Pump provides pulse-free, continuous fluid inflow for joint distention when used in conjunction with a high flow sheath or separate inflow cannula....
True/Fix Distal Femoral Nail System...
Medicine Products: