Navigation Links
Multi-Pronged Therapeutic Cancer Vaccine Regimen to be Studied in Melanoma Patients
Date:9/17/2008

PARIS, and TORONTO, Sept. 17 /PRNewswire/ -- Sanofi pasteur, the vaccines division of the sanofi-aventis Group, announced today that it is sponsoring a Phase II clinical study exploring a multi-pronged treatment approach to high risk and advanced-stage melanoma -- an often fatal form of cancer for which there are limited treatment options. Patients are being enrolled in the United States and Canada. The trial, called MEL11, will investigate the safety and efficacy of a therapeutic cancer vaccine regimen aimed at stimulating the body's immune system to fight melanoma.

"The MEL11 study uses an entirely new treatment approach to advanced-stage melanoma," said Teresa Petrella, MD, Medical Oncologist and Clinical Researcher at the Odette Cancer Centre at the Sunnybrook Health Sciences Centre in Toronto and the lead investigator of the trial. "The study protocol combines the use of a vaccine with more traditional anti-cancer agents to bolster the effectiveness of the immune system. Melanoma is an increasing concern in the cancer community; its incidence is on the rise and there are very few available treatment options."

The vaccine candidate is uniquely designed to stimulate the body's own defenses -- the immune system -- to find and fight cancer cells. It makes use of a modified canarypox virus, ALVAC(2), which has been shown in an extensive body of research to promote immune responses in humans. The ALVAC(2) virus contains the genes for five antigens -- molecules that induce an immune response -- that are commonly found in melanoma tumors. These antigens stimulate T-cells within the immune system to hone in on melanoma cells, and are expected to halt or slow cancer progression. The vaccine also contains the genes for three proteins called co-stimulatory molecules, which increase the immune response of T-cells to the antigens. In addition to the vaccine, patients in this trial will be treated with two other agents that augment the immune response: GM
'/>"/>

SOURCE sanofi pasteur
Copyright©2008 PR Newswire.
All rights reserved

Page: 1 2 3 4 5

Related medicine technology :

1. Vicus Therapeutics to Present at the 234th American Chemical Society National Meeting in Boston, MA
2. Allos Therapeutics Initiates Study of PDX in Patients with Cutaneous T-Cell Lymphoma
3. Amicus Therapeutics Announces Second Quarter 2007 Financial Results
4. TorreyPines Therapeutics Completes Patient Enrollment in Phase IIb Clinical Trial of Tezampanel for the Treatment of Acute Migraine Headache
5. CV Therapeutics Announces Eight Abstracts Accepted for Presentation at the European Society of Cardiology Congress 2007
6. Pharmacopeia Assists the World Health Organization in the Discovery of Novel Therapeutics for the Treatment of Malaria
7. Protalix BioTherapeutics Treats First Patient in Phase III Clinical Trial of prGCD
8. TorreyPines Therapeutics Initiates a Phase I Multiple Dose Clinical Trial of Tezampanel
9. Zila Inc. Product Selected to Identify Pre-Cancer in Study of Leading Cancer Treatment Chemotherapeutic - ERBITUX
10. Advanced Life Sciences to Present Data on Selected Cethromycin Therapeutic Studies at the 47th Interscience Conference on Antimicrobial Agents and Chemotherapy
11. TorreyPines Therapeutics Completes Phase I Multiple Dose Clinical Trial of NGX267, a Selective M1 Agonist for the Potential Treatment of Cognitive Impairment Associated with Schizophrenia

Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/29/2009)...wswire/ -- Stimulated by the ten years of Synapse&...Systems USA announced today, at the Radiological S... formation of its Medical Informatics Division . ...p will integrate all functions associated with the...form for future growth. ,, Several organization...
(Date:11/27/2009).... 27 Booth - 3646/South ... ), a premier supplier of X-ray tubes and flat pan...range of detectors at the RSNA Annual Meeting in C... Varian will also be exhibiting X-ray tube technol... cancer treatment technologies. ,, Varian,s ex...
(Date:11/25/2009)...v. 25 American Scientifi...") is pleased to announce that they have opened a ...e in Shanghai, China. ,, ASR has been able to s...teway for the development and production of curren...en and adults to be distributed and sold globally....
Breaking Medicine Technology:FUJIFILM Establishes Medical Informatics Organization 2FUJIFILM Establishes Medical Informatics Organization 3Varian Medical Systems to Highlight the Latest Digital Detectors, X-ray Tubes and Cancer Treatment Technology at the Radiological Society of North America (RSNA) Annual Meeting in Chicago 2American Scientific Resources Inc. Opens Shanghai Location 2Virtual maps for the blind 56801 1Virtual maps for the blind 56801 2Virtual maps for the blind 56801 3Superscanner helps scientists see into the unknown 9873 1Superscanner helps scientists see into the unknown 9873 2Superscanner helps scientists see into the unknown 9873 3Size of fat cells and waist size predict type 2 diabetes in women 9869 1Size of fat cells and waist size predict type 2 diabetes in women 9869 2
... ANTONY, France, January 19 Stallergenes S.A.,...he German agency in charge,of regulating biologica...iatric extension (5-17 years) of the indications f...sitization to grass pollens. , The marketing a...08.,Oralair(R) Grasses will therefore be marketed ...
... WILMINGTON, N.C., Jan. 19 Intercell AG has re...heir Phase III clinical trial of a,Travelers, Diar...e form of a,skin patch -- a novel method for deliv...use it is needle-free. , This year, approximat...countries where bacteria that cause TD are endemic...
Other Medicine Technology:STALLERGENES: Oralair(R) Grasses Obtains a Pediatric MA(1) in Germany 2STALLERGENES: Oralair(R) Grasses Obtains a Pediatric MA(1) in Germany 3STALLERGENES: Oralair(R) Grasses Obtains a Pediatric MA(1) in Germany 4Intercell AG Partners with Inclinix to Enroll 1800 Volunteers for Phase III Travelers' Diarrhea Vaccine Study 2Intercell AG Partners with Inclinix to Enroll 1800 Volunteers for Phase III Travelers' Diarrhea Vaccine Study 3
(Date:11/28/2009)...RNewswire/ -- Get ready for advanced visualizat...ine when Siemens introduces syngo. via(1)...ing of the Radiological Society of North America (...Place (Booth #825, East Building/Lakeside Center, ...ens, new imaging software for multimodality readin...
(Date:11/28/2009)...pirits, recognize signs of depression , ,...eniors, the holiday season can trigger melancholy ... health issues or worry about money problems, acco...help overcome the seasonal blues, the AGS Foundati...: , Get out and socialize or invite family and f...
(Date:11/27/2009)... firm Replikins Ltd. today issued its latest bioch...t shows that the lethality of the virus has droppe...,s current outbreak in the spring of 2009 to resti.... The H1N1 infectivity count, however, remains inc...November 27, 2009 -- Biotech firm Replikins Ltd., ...
(Date:11/27/2009)... 27 Preventing disease ...unately every year, new vaccines are being added t...s boost immunity for the same period of time? And,...d to keep immunity strong? ,, In this month,s...Academy of Pediatrics, Michael Pichichero MD, Dire...
(Date:11/27/2009)...e Holdings has announced that it has become a nati...he largest nonprofit organizations dedicated to ar... Delray Beach, FL (Vocus) No... XCHO), a company specializing in the marketing an...cts, has announced today that is has become a nati...
Breaking Medicine News(10 mins):Health News:Siemens Boosts Advanced Image Reading Efficiency and Opens New Path Into The Clinical Routine with syngo(R).via 2Health News:Siemens Boosts Advanced Image Reading Efficiency and Opens New Path Into The Clinical Routine with syngo(R).via 3Health News:Siemens Boosts Advanced Image Reading Efficiency and Opens New Path Into The Clinical Routine with syngo(R).via 4Health News:Siemens Boosts Advanced Image Reading Efficiency and Opens New Path Into The Clinical Routine with syngo(R).via 5Health News:Seniors May Need Help Overcoming Holiday Blues 2Health News:Lethality of H1N1 Virus Drops to "Non-Epidemic Resting Levels" in Current Cycle; Virus' Infectivity Remains Increased 2Health News:Lethality of H1N1 Virus Drops to "Non-Epidemic Resting Levels" in Current Cycle; Virus' Infectivity Remains Increased 3Health News:Lethality of H1N1 Virus Drops to "Non-Epidemic Resting Levels" in Current Cycle; Virus' Infectivity Remains Increased 4Health News:Lethality of H1N1 Virus Drops to "Non-Epidemic Resting Levels" in Current Cycle; Virus' Infectivity Remains Increased 5Health News:Why Some Vaccines May Require A Booster 2Health News:Why Some Vaccines May Require A Booster 3Health News:XenaCare Holdings Announces National Sponsorship of the Arthritis Foundation 2Health News:XenaCare Holdings Announces National Sponsorship of the Arthritis Foundation 3Health News:XenaCare Holdings Announces National Sponsorship of the Arthritis Foundation 4
..., June 12, 2008 A material designed to prevent ad...rsity Prof. Daniel Cohn of the Casali Instititue o...e Awards for Innovation. The awards were presented...ar weight) that generate a physical barrier betwee...
...nce, Thursday 12 June 2008: Low bone mineral densi...tality in patients with rheumatoid arthritis (RA) ...new study presented today at EULAR 2008, the Annua...ffective predicting mortality as well-established ...
... 12 /Xinhua-PRNewswire-FirstCall/ -- China Medical... ), a leading China-based,medical device company t...-,vitro diagnostic products and high intensity foc...scal year ended,March 31, 2008 ("FY2007")., 4Q F...
...h., June 12 A few months ago, members of,Congress...a misperception,of many Americans approaching reti...dicare would cover their long-term care expenses,".... "It wasn,t,so, but the wording of the Social Sec...
...R, Ill. Delaying an adolescents school start time...ognitive performance, according to a research abst...008, the 22nd Annual Meeting of the Associated Pro...m two classes, who were divided into experimental ...
...R, Mich. A type of stroke that can strike at any ...o be more common in women and Mexican-Americans th...tudy from the University of Michigan Stroke Progra... type of stroke related to a ruptured brain aneury...
Other Medicine News:Health News:Invention to prevent surgical adhesions wins Kaye Award 2Health News:Hand bone mineral density is an effective predictor of mortality in rheumatoid arthritis 2Health News:China Medical Technologies Reports Fourth Quarter and Full Year Financial Results 2Health News:China Medical Technologies Reports Fourth Quarter and Full Year Financial Results 3Health News:China Medical Technologies Reports Fourth Quarter and Full Year Financial Results 4Health News:China Medical Technologies Reports Fourth Quarter and Full Year Financial Results 5Health News:China Medical Technologies Reports Fourth Quarter and Full Year Financial Results 6Health News:China Medical Technologies Reports Fourth Quarter and Full Year Financial Results 7Health News:China Medical Technologies Reports Fourth Quarter and Full Year Financial Results 8Health News:China Medical Technologies Reports Fourth Quarter and Full Year Financial Results 9Health News:China Medical Technologies Reports Fourth Quarter and Full Year Financial Results 10Health News:China Medical Technologies Reports Fourth Quarter and Full Year Financial Results 11Health News:China Medical Technologies Reports Fourth Quarter and Full Year Financial Results 12Health News:China Medical Technologies Reports Fourth Quarter and Full Year Financial Results 13Health News:China Medical Technologies Reports Fourth Quarter and Full Year Financial Results 14Health News:China Medical Technologies Reports Fourth Quarter and Full Year Financial Results 15Health News:China Medical Technologies Reports Fourth Quarter and Full Year Financial Results 16Health News:China Medical Technologies Reports Fourth Quarter and Full Year Financial Results 17Health News:China Medical Technologies Reports Fourth Quarter and Full Year Financial Results 18Health News:China Medical Technologies Reports Fourth Quarter and Full Year Financial Results 19Health News:Social Security Statement Advises Seniors to Consider Private Long-Term Care Insurance, LTC Agency Reports; Medicare Won't Cover It 2Health News:Delaying school start time by one hour positively affects adolescents' cognitive performance 2Health News:Women, Mexican-Americans at higher risk of ruptured brain aneurysm 2Health News:Women, Mexican-Americans at higher risk of ruptured brain aneurysm 3
...boratory," it brings to mind images of test tubes,...tems. With the introduction of the Brady Code Read... list of critical lab tools. Brady Corporation has...he lab with the introduction of the CR2. It is the...
VisionMate1
Laboratory Table; Sealed Laminate Top
Tables
Medicine Products: