Navigation Links
Mpex Pharmaceuticals Presents Positive Phase 2 Clinical Trial Results of Aeroquin(TM) (MP-376) Treatment in Cystic Fibrosis Patients
Date:5/17/2010

>The trial met the primary endpoint of a reduction in sputum Pseudomonas aeruginosa density at Day 28, the end of treatment.  All three doses of Aeroquin demonstrated statistical significance (p < 0.01 for each group versus placebo), with the highest dose (240 mg BID) showing the greatest effect of approximately 1 log reduction.  There was no evidence for emergence of bacterial resistance during the study.

Improvements in respiratory function were also demonstrated in the trial.  A greater proportion of patients had improvement in percent predicted FEV1 with any dose of Aeroquin compared to placebo, with a difference of 10.9% in percent predicted FEV1 between the 240mg BID group and placebo at day 28 (p=0.0008).  Patients treated with 240 mg BID also had a 22% improvement in FEF25-75 (p<0.0001) and a 7.3% improvement in percent predicted FVC (p=0.014) at day 28 versus placebo.  FEV1, FEF25-75 and FVC are standard measures of lung function in CF patients.

Consistent with these results, a statistically significant reduction in the need for other inhaled and/or systemic anti-pseudomonal antimicrobials was observed in all Aeroquin groups vs. placebo (risk reduction of 79% for 240mg BID vs. placebo; p=0.0007). The percent of patients with adverse events (AEs) was similar across all treatment groups, with no evidence of increasing incidence or severity of AEs with increasing Aeroquin dose.

"The results from the Aeroquin Phase 2b CF trial are very encouraging both in terms of the improvement in lung function and the reduction in the need for other anti-pseudomonal antimicrobials," stated Dr. Conrad. "The combination of these outcomes with an attractive safety profile to date and a convenient dosing regimen makes Aeroquin a potentially important new agent.  These results were especially impressive because they were obtained in a
'/>"/>

SOURCE Mpex Pharmaceuticals, Inc.
Copyright©2010 PR Newswire.
All rights reserved

Page: 1 2 3 4 5

Related medicine technology :

1. Jiangbo Pharmaceuticals Reports Results for Third Quarter of Fiscal Year 2010
2. Lotus Pharmaceuticals, Inc. Reports Strong First Quarter 2010 Financial Results
3. DUSA Pharmaceuticals Announces Slate of Nominees for Election to the Board of Directors
4. Ferring Pharmaceuticals Announces Disco Icon Gloria Gaynor as National Spokesperson for EUFLEXXA(R)
5. Biostar Pharmaceuticals, Inc. to Host Fiscal Year 2010 First Quarter Earnings Conference Call on Monday, May 17, 2010 at 9:30 a.m. ET
6. Jazz Pharmaceuticals Announces Public Offering of Common Stock
7. China Yongxin Pharmaceuticals is Selected as one of the Qualified Pharmaceutical Distributors for Jilin Province
8. Epix Pharmaceuticals, Inc. Announces Additional Information Concerning the May 28, 2010 Auction Sale of EP-2104R MRI Imaging Agent
9. ADVENTRX Pharmaceuticals to Present at the Rodman & Renshaw Annual Global Investment Conference on May 17
10. Ferring Acquires LYSTEDA(TM) From Xanodyne Pharmaceuticals, Inc.
11. Ampio Pharmaceuticals, Inc. Appoints New Chairman and Chief Financial Officer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/22/2014)... data demonstrates that flibanserin, a novel, non-hormonal medicine being ... dysfunction, Hypoactive Sexual Desire Disorder (HSDD), does not impair ... when taken at bedtime. The data was presented at ... (SMSNA) 20th Annual Fall Scientific Meeting in ... accepted this study as a late breaking abstract for ...
(Date:11/22/2014)... Nov. 21, 2014 MEDITE Group acquired by CytoCore, ... and the 3 rd quarter sales ended September 30, ... $448,000 for the nine months ended September 2014 and a ... our 3 rd quarter is usually a seasonable weak ... July into September for many countries worldwide, we are proud ...
(Date:11/21/2014)... 21, 2014  The University of Maryland,s A. James ... groundbreaking of the new A. James Clark Hall at ... will cultivate transformative new engineering and biomedical technologies to ... at 10:00 a.m. on November 21 at the site ... Lot, adjacent to the Jeong H. Kim Engineering Building, ...
Breaking Medicine Technology:Study on Efficacy and Sedation-Related Safety of Flibanserin in Premenopausal Women Released Today at Sexual Medicine Society of North America Meeting 2Study on Efficacy and Sedation-Related Safety of Flibanserin in Premenopausal Women Released Today at Sexual Medicine Society of North America Meeting 3CytoCore Inc. / MEDITE Cancer Diagnostics, Inc. Reports Record YTD and 3rd Quarter Sales 2CytoCore Inc. / MEDITE Cancer Diagnostics, Inc. Reports Record YTD and 3rd Quarter Sales 3University of Maryland Breaks Ground for A. James Clark Hall 2University of Maryland Breaks Ground for A. James Clark Hall 3University of Maryland Breaks Ground for A. James Clark Hall 4
... poultry ... processing plants., SHREVEPORT, La., Nov. ... poultry processing, was identified,in an October 2007 Watt Poultry USA article ... in large-scale processing plants, University of,Georgia Associate Professor of Poultry Science ...
... DEERFIELD, Ill., Nov. 6 In,recognition of her ... sexual behaviors among African-American, South-African and,Latino youth and ... Tau,International, announced the selection of Loretta Sweet Jemmott, ... 2007 Episteme Award. Jemmott was presented with ...
Cached Medicine Technology:FreshFx Recognized for use in the Scalder as a Solution to the 'Yield/Pathogen Reduction Dilemma' 2Honor Society of Nursing Recognizes Researcher of HIV Risk Prevention for Poor and Underserved 2Honor Society of Nursing Recognizes Researcher of HIV Risk Prevention for Poor and Underserved 3
(Date:11/24/2014)... SafeHandles™ announced that they will be featured in ... airing via Discovery Channel. Dates and show times TBA. ... replaceable, and affordable germ protective device. This segment will ... adhesives to promote hand hygiene in high traffic and ... is the desire to make a positive impact in ...
(Date:11/24/2014)... "My friend was killed when a vehicle ... street in his motorized wheelchair," said an inventor from ... up with this idea so that people in wheelchairs ... the Safety Lites to make a wheelchair highly visible, ... ensures that motorists can see the wheelchair. This helps ...
(Date:11/23/2014)... The report, “Market Snapshot: Aesthetic ... - Asia-Pacific” provides quantitative analysis of the three ... invasive body contouring devices, non-invasive body contouring devices ... size data by revenue and volume over the ... Japan, South Korea, Australia and India. It uses ...
(Date:11/23/2014)... friends have more influence on teens, alcohol use than ... "We,ve known for a long time that ... use, but there are no common studies that distinguished ... influence on those decisions," Jonathon Beckmeyer, an assistant professor ... a university news release. Beckmeyer analyzed data gathered ...
(Date:11/23/2014)... To show thanks to new and old customers, ... evening dresses for weddings. Customers who need custom outfits ... a distinguished dress manufacturer, and it is among the ones ... a very long time. The CEO of this company says, ... able to buy not only a beautiful dress, but also ...
Breaking Medicine News(10 mins):Health News:New Episode of Innovations TV Series to Feature SafeHandles™ 2Health News:Aesthetic Lasers and Energy Devices Market in APAC (China, Japan, South Korea, Australia and India) to 2020 2Health News:Aesthetic Lasers and Energy Devices Market in APAC (China, Japan, South Korea, Australia and India) to 2020 3Health News:Aesthetic Lasers and Energy Devices Market in APAC (China, Japan, South Korea, Australia and India) to 2020 4Health News:Close Friends May Be Key to Teens' Drinking 2Health News:iFitDress.com: Wonderful White Evening Dresses Now Available 2
... -- Researchers from Duke University, the University of Cincinnati ... hoping to find a geographical pattern to help explain ... disease amyotrophic lateral sclerosis (ALS) at twice the normal ... layering military records of troop locations onto Gulf-area maps, ...
... in Progressive Inflammatory brain Disease) study at the Peninsula Medical ... news that the full cohort of 493 people with multiple ... is a clinical trial which will evaluate whether tetrahydrocannabinol (THC), ... plant (and the main active ingredient) is able to slow ...
... the only ones who need to be concerned about ... may trigger serious cardiovascular problems for some spectators. ... at Northwestern University,s Feinberg School of Medicine warn that ... of pollution can cause heart attacks and strokes within ...
... N.H., July 21 iCAD, Inc. (Nasdaq:,ICAD), an ... the completion of its previously announced,agreement to purchase ... technology company based in White Plains, NY. The,purchase ... in cash and,1,086,957 shares of iCAD common stock. ...
... Experienced a 15 Percent Increase in Prescription ... Report from HealthLeaders-InterStudy, NASHVILLE, Tenn., July ... care market intelligence, reports that Excellus,BlueCross BlueShield ... pharmacy programs and public education efforts. According ...
... Ala., July 21 Health,Care Systems, Inc. (HCS), ... market leader in medication reconciliation solutions, has entered,into ... the largest,locally owned not-for-profit hospitals in the nation ... as a teaching facility for The,University of Alabama ...
Cached Medicine News:Health News:Researchers probe geographical ties to ALS cases among 1991 Gulf War veterans 2Health News:Researchers probe geographical ties to ALS cases among 1991 Gulf War veterans 3Health News:Milestone for cannabinoid MS study 2Health News:Beijing pollution may trigger heart attacks, strokes 2Health News:iCAD Completes Acquisition of CAD Sciences 2Health News:New York's Excellus BlueCross BlueShield to Continue Generic Medication Promotion to Help Control Costs 2Health News:Huntsville Hospital Signs With Health Care Systems, Inc. for Automated Medication Reconciliation Services 2
Gently curved shaft with blunt angled tip is ideal for chopping the lens during anterior chamber phacoemulsification....
5 mm curved hook with markings at 14 mm and 20 mm from tip. Flat serrated handle with polished finish. Overall length: 4.7 inches....
#2 10 mm hook. Flat serrated handle with polished finish. Overall length: 5.5 inches....
2.0 mm bulbous tip with 6 mm flat portion. Flat serrated handle with polished finish. Overall length: 5.4 inches. Most popular size or model....
Medicine Products: