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Mpex Pharmaceuticals Presents New Data on MP-376 in Cystic Fibrosis
Date:10/23/2008

ese beneficial anti-inflammatory effects were not observed with tobramycin or aztreonam.

"We believe that taken together these studies show a very attractive profile for MP-376 in the treatment of chronic bacterial infections in CF patients," stated Dr. Michael Dudley, Senior VP of R&D and Chief Scientific Officer of Mpex Pharmaceuticals. "MP-376 has the potential to address many of the current shortcomings with inhaled antibiotic treatments in CF. The combination of the inherent potency of levofloxacin and the novel formulation we have developed for aerosol administration may allow us to achieve the desired pharmacokinetic and pharmacodynamic parameters that are necessary for long-term success in this indication. We look forward to working with CF patients and caregivers to move this potentially important new treatment option through development."

About MP-376

MP-376 is a proprietary formulation of levofloxacin that has been optimized for aerosol delivery using a customized Investigational eFlow(R) Nebulizer System (PARI Pharma, Munich, Germany). Levofloxacin is a fluoroquinolone antibiotic that has been widely used in a variety of indications for over a decade and has established safety and efficacy when administered orally or intravenously against many bacterial pathogens, including P. aeruginosa. Administration of MP-376 with a high efficiency nebulizer to the lungs allows for the delivery of high concentrations of active drug directly to the site of infection, while minimizing systemic exposure. Mpex believes this approach has the potential to improve bacterial killing and reduce resistance development versus traditional oral or IV routes of administration.

About Mpex Pharmaceuticals

Mpex Pharmaceuticals is a clinical stage biopharmaceutical company whose mission is to develop important new therapies to combat the growing issue of antibiotic resistance. The company's internal development pipeline focuses on combining proprieta
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SOURCE Mpex Pharmaceuticals, Inc.
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